25-hydroxyvitamin D levels and body mass index in healthy postmenopausal women

Abstract

Vitamin D (VtD) endocrine system is associated with obesity. The relationship between VtD and body fat was described originally by Lumb et al. [1]. Subsequently murine experiment and human study revealed that body fat is the major storage site of vitamin D3 and the source for other VtD metabolites during deprivation as well [2,3]. The reasons of VtD insuffi ciency in obese people have been postulated to several factors such as a decrease exposure to sunlight because of low activity level, a negative feedback from elevated active VtD metabolite 1,25-hydroxyvitamin D and parathyroid hormone (PTH) levels on hepatic synthesis of 25-OHD [4], and the metabolic clearance of VtD may increase in obesity with enhanced uptake by adipose tissue [5]. Recently, Worstman et al. [6] also demonstrated that obesity-associated VtD insuffi ciency most likely ORIGINAL ARTICLE Korean J Obstet Gynecol 2012;55(6) Objective Obesity is associated with alterations in vitamin D (VtD) system. We evaluated the correlation between VtD level and body mass index (BMI), a standard for the evaluation of obesity in postmenopausal women. MethodsTo study the relationship between VtD levels and obesity, we recruited 310 healthy postmenopausal women between January 2005 and March 2011 and analyzed the correlation between BMI and serum 25-hydroxyvitamin D (25-OH-VtD) level. We also analyzed the relationship between serum VtD level and bone health status such as bone mineral density measured by dual-energy X-ray absorptiometry, bone turnover marker, and parathyroid hormone (PTH). ResultsWith a cut-off level for VtD deficiency at 30 ng/mL, 98.9% patients showed a VtD deficiency, while 87.8% patients showed a vitamin D defi ciency with a 20-ng/mL cut-off level. VtD levels had no signifi cant correlation with age, height, weight, BMI, or bone turnover markers. PTH level and serum 25-OH-VtD level showed a negative correlation. VtD level showed negative correlation with BMI, but statistically not signifi cant. ConclusionIn this study, most of postmenopausal women (more than 87.8%) had a VtD defi ciency, and VtD level showed negative correlation with BMI, but was not statistically signifi cant.

Optimal Serum 25(OH)D Levels and Vitamin D Intake in Korean Postmenopausal Women

“…Despite the expectation of an increase in the serum 25(OH)D levels with age due to higher levels in postmenopausal women than young women, age was not identified as a variable affecting the serum 25(OH)D levels. Similar findings were reported in previous studies conducted in Korean [40], Chinese [41], and Japanese [42] postmenopausal women, indicating no correlation between age and serum 25(OH)D levels. Adequate vitamin D intake and UV radiation were found to be able to sustain the serum 25(OH)D levels even in the presence of increased body fat and reduced vitamin D3 synthesis in the skin.…”

Comparison of Herbal Medicines Used for Women’s Menstruation Diseases in Different Areas of the World

“…ex DC. (Cirsii Japonici Herba Carbonisata), Elsholtzia splendens Nakai ex F. Maekawa (Jang et al, 2012).…”