25-Hydroxyvitamin D levels and bone mineral density evaluation in patients with cholecystectomy: a case-control study

Ekiz, Timur; Yeğen, Serkan Fatih; Katar, Mehmet Kağan; Genç, Ömer; Genç, Selin

doi:10.1007/s11657-018-0435-7

Cited by 12 publications

(16 citation statements)

References 15 publications

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“…In several previous studies, lower vitamin D level and lower BMD was noted in patients with previous cholecystectomy ( 20 , 21 ). On the other hand, other studies showed a lower vitamin D level but similar BMD following cholecystectomy ( 22 , 23 ). The discrepancy may be due to the small sample size of these studies.…”

Section: Introductionmentioning

confidence: 80%

“…To the best of our knowledge, this is the first study to investigate the incidence of fracture in participants who underwent cholecystectomy. To date, only a few published papers have evaluated the possible relationship between osteoporosis and cholecystectomy (20)(21)(22)(23)30). Osteoporosis is a common health problem with an increased financial burden; osteoporotic fracture is the most worrying complication of osteoporosis.…”

Section: Discussionmentioning

confidence: 99%

“…Osteoporosis is a common health problem with an increased financial burden; osteoporotic fracture is the most worrying complication of osteoporosis. In previous studies, serum vitamin D levels following cholecystectomy were studied as a possible factor increasing the risk of osteoporosis (20)(21)(22). Adequate calcium and vitamin D intake play a key role in not only optimal peak where the income level falls in the bottom 20% of the health insurance premium.…”

Section: Discussionmentioning

confidence: 99%

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The Association Between Cholecystectomy and the Risk for Fracture: A Nationwide Population-Based Cohort Study in Korea

et al. 2021

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ObjectivesTo evaluate the risk of fracture in individuals with a history of cholecystectomy in Korean population.MethodsIndividuals (n = 143,667) aged ≥ 40 y who underwent cholecystectomy between 2010 and 2015 and the controls (n = 255,522), matched by age and sex, were identified from the database of the Korean National Health Insurance Services. The adjusted hazard ratio (aHR) and 95% confidence interval (CI) of fracture were estimated following cholecystectomy, and a Cox regression analysis was performed.ResultsThe incidence rates of all fractures, vertebral, and hip fractures were 14.689, 6.483 and 1.228 cases per 1000 person-years respectively in the cholecystectomy group, whereas they were 13.862, 5.976, and 1.019 cases per 1000 person-years respectively in the control group. After adjustment for age, sex, income, place of residence, diabetes mellitus, hypertension, dyslipidemia, smoking, alcohol drinking, exercise, and body mass index, patients who underwent cholecystectomy showed an increased risk of all fractures, vertebral fractures, and hip fractures (aHR [95% CI]: 1.095 [1.059-1.132], 1.134 [1.078-1.193], and 1.283 [1.139-1.444] for all fractures, vertebral fractures, and hip fractures, respectively). The risk of vertebral fractures following cholecystectomy was more prominent in the young age group (40 to 49 y) than in the old age group (≥ 65 y) (1.366 [1.082-1.724] vs. 1.132 [1.063-1.206], respectively). However, the incidence of hip fractures following cholecystectomy was not affected by age.ConclusionIndividuals who underwent cholecystectomy have an increased risk of fracture. In the younger population, the risk of vertebral fractures may be further increased following cholecystectomy.

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Section: Introductionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The Association Between Cholecystectomy and the Risk for Fracture: A Nationwide Population-Based Cohort Study in Korea

et al. 2021

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“…They concluded that individuals undergoing cholecystectomy were at a higher risk of vertebral fractures at a younger age (<50yrs). Literature supports the harmful effect of cholecystectomy on VD status; however, the mechanistic relationship of VD absorption with cholecystectomy and lower serum 25(OH)D levels needs further elaboration (8)(9)(10).…”

Section: Editorial On the Research Topicmentioning

confidence: 99%

“…In postmenopausal osteoporotic females, serum VD levels were lower in comparison to serum resistin levels, and VD was declared to be a negative predictor of increased serum resistin concentration. The research proposes that hypovitaminosis D is a risk factor for IR independent of adiposity ( 10 ).…”

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confidence: 99%

Editorial: Vitamin D Deficiency and Sufficiency in Reproduction and Bone Metabolism

et al. 2021

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Sarcopenia and sarcopenic obesity after cholecystectomy: A population‐based study

Gan

Wang

et al. 2021

Obesity

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Objective: The present study aimed to investigate the associations of cholecystectomy with low muscle mass, low muscle strength, sarcopenia, and sarcopenic obesity. Methods:This population-based study included data from 4,909 participants aged 18 to 80 years. History of cholecystectomy was diagnosed using abdominal ultrasonography. Muscle mass was evaluated using a dual-energy x-ray absorptiometry scan, and muscle strength was evaluated using an electronic hand dynamometer.Sarcopenia was defined as the presence of both low muscle mass and low muscle strength. Sarcopenic obesity was defined as the presence of both sarcopenia and obesity. Multivariable logistic regression models were performed to investigate the associations of cholecystectomy with low muscle mass, low muscle strength, sarcopenia, and sarcopenic obesity.Results: Participants with history of cholecystectomy were more likely than those without to have low muscle mass, low muscle strength, and sarcopenia. Furthermore, compared with cholecystectomy that occurred within 7 years (7 years is the median interval between cholecystectomy and the physical examination), participants with cholecystectomy that occurred more than 7 years ago had higher odds of sarcopenia. Finally, whether obesity was defined by BMI or body fat percentage, cholecystectomy was positively associated with sarcopenic obesity. Conclusions:Cholecystectomy is associated with low muscle mass, low muscle strength, sarcopenia, and sarcopenic obesity.

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25-Hydroxyvitamin D levels and bone mineral density evaluation in patients with cholecystectomy: a case-control study

Abstract: In the light of our results, cholecystectomy patients seem to have lower level of 25(OH) D levels in comparison with healthy subjects, but both groups have similar BMD values. Further studies in cohort designs taking into account the bone formation and resorption markers are awaited.

Cited by 12 publications

References 15 publications

The Association Between Cholecystectomy and the Risk for Fracture: A Nationwide Population-Based Cohort Study in Korea

The Association Between Cholecystectomy and the Risk for Fracture: A Nationwide Population-Based Cohort Study in Korea

Editorial: Vitamin D Deficiency and Sufficiency in Reproduction and Bone Metabolism

Sarcopenia and sarcopenic obesity after cholecystectomy: A population‐based study

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