25(OH)D Serum Levels Decline With Age Earlier in Women Than in Men and Less Efficiently Prevent Compensatory Hyperparathyroidism in Older Adults

Maggio, Dario; Cherubini, Antonio; Lauretani, Fulvio; Russo, Roberto; Bartali, Benedetta; Pierandrei, Marco; Ruggiero, Carmelinda; Macchiarulo, Maria Carmela; Giorgino, R.; Minisola, Salvatore; Ferrucci, Luigi

doi:10.1093/gerona/60.11.1414

Cited by 74 publications

(59 citation statements)

References 35 publications

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“…Although 25(OH)D levels were reported to be lower in elderly people based on diminished cutaneous production of vitamin D with ageing, lower sun exposure due to spending little time outdoors and lower Ca intake in the elderly (5) , the frequency of vitamin D deficiency was identified to be much higher in younger patients than in patients aged $45 years in our study population, which might be related to more common use of vitamin D supplements in the elderly. Interestingly, supporting the significantly lower 25(OH)D levels in our elderly but not younger female patients when compared with males, the age-related fall in vitamin D level was previously reported not to be the same in both genders and suggested to occur at a younger age in women than men (5,21) . While strong seasonal variation in serum 25(OH)D with a marked downward shift during the winter months has been reported consistently (22) , identification of vitamin D deficiency even in the summer months in our countrywhich has, in most of its geographic regions, sufficient sunshine to maintain adequate vitamin D status by dermal synthesis (23)(24)(25) -seems worth noting.…”

Section: Discussionsupporting

confidence: 85%

Vitamin D deficiency is a problem for adult out-patients? A university hospital sample in Istanbul, Turkey

Ciğerli

Parıldar

Ünal

et al. 2012

Public Health Nutr.

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Objective: To investigate the frequency of vitamin D deficiency in relation to demographics, clinical diagnosis, season of measurement and laboratory parameters in adult out-patients. Design: Descriptive, retrospective study concerning evaluation of the initial 25-hydroxyvitamin D (25(OH)D) levels determined at admission in relation to demographics, clinical diagnosis, season of measurement and laboratory parameters. 25(OH)D levels ,20 ng/ml were classified as deficiency, 20-30 ng/ml as insufficiency and .30 ng/ml as sufficiency. Setting: Out-patient clinics at a tertiary care centre. Subjects: A total of 2488 adult patients (mean age: 53?3 (SD 15?2) years; 85?2 % were females) admitted to out-patient clinics at Baskent University Istanbul Hospital were included. Results: Mean level of 25(OH)D in the overall population was 17?4 (SD 11?5) ng/ml while insufficiency and deficiency were evident in 24 % and 66 % of patients, respectively. Mean 25(OH)D levels in males .45 years old were higher than in their female counterparts (19?4 (SD 11?3) ng/ml v. 17?8 (SD 12?2) ng/ml; P , 0?05). Mean 25(OH)D levels obtained in summer (18?6 (SD 11?1) ng/ml) and autumn (23?3 (SD 13?6) ng/ml) were significantly higher than levels in spring (16?1 (SD 10?3) ng/ml) and winter (14?6 (SD 10?2) ng/ml; P , 0?01). Mean 25(OH)D levels were determined to be significantly lower in obese patients compared with non-obese patients (15?6 (SD 10?4) ng/ml v. 17?6 (SD 11?6) ng/ml; P , 0?05). Levels of 25(OH)D were significantly negatively correlated with serum parathyroid hormone levels (r 5 20?194; P , 0?001) while significantly positively correlated with phosphorus (r 5 0?059; P , 0?01) and HDL cholesterol (r 5 0?070; P , 0?01) levels. Conclusions: Our findings indicate that vitamin D deficiency is very common among out-patients in Turkey, regardless of gender and age, especially among obese people and during winter and spring.

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Section: Discussionsupporting

confidence: 85%

Vitamin D deficiency is a problem for adult out-patients? A university hospital sample in Istanbul, Turkey

Ciğerli

Parıldar

Ünal

et al. 2012

Public Health Nutr.

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“…However, whether the beneficial effects of exercise and muscle strength affect trabecular or cortical bone and/or bone geometry is still unclear. Likewise, vitamin D deficiency is frequent in older persons [13], especially in older women and, together with a compensatory elevation of PTH serum levels, potentially contributes to accelerate bone loss in older individuals [14]. In a recent study, vitamin D but not estradiol or free testosterone predicted fractures in older men [15].…”

Section: Introductionmentioning

confidence: 99%

Correlates of bone quality in older persons

Lauretani

Bandinelli²,

Russo

et al. 2006

Bone

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Purpose of the study-In a population-based sample of older persons, we studied the relationship between tibial bone density and geometry and factors potentially affecting osteoporosis.Methods-Of the 1260 participants aged 65 years or older eligible for the InCHIANTI study, 1155 received an interview and 915 (79.2%) had complete data on tibial QCTscans and other variables used in the analysis presented here. The final study population included 807 persons (372 men and 435 women, age range 65-96 years) after exclusion of participants affected by bone diseases or treated with drugs that interfere with bone metabolism.Results-In both sexes, calf cross-sectional muscle area (CSMA) was significantly and independently associated with total bone cross-sectional area (tCSA) and cortical bone crosssectional area (cCSA) but not with trabecular or cortical volumetric bone mineral density (vBMD). Bioavailable testosterone (Bio-T) was independently associated with both trabecular and cortical vBMD in both sexes. In women, independently of confounders, 25(OH)-vitamin D was positively associated with tCSA and cortical vBMD, while PTH was negatively associated with cortical vBMD. IL-1 beta was negatively correlated with cortical vBMD in women, while TNF-alpha was associated with enhanced bone geometrical adaptation in men.Conclusions-Physiological parameters that are generically considered risk factors for osteoporosis were associated with specific bone parameters assessed by tibial QCT. Factors known to be associated with increased bone reabsorption, such as 25(OH)-vitamin D, PTH and Bio-T, affected mainly volumetric BMD, while factors associated with bone mechanical stimulation, such as CSMA, affected primarily bone geometry. Our results also suggested that pro-inflammatory cytokines might be considered as markers of bone resorption.*Corresponding

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“…Forrest et al (2011) found that the rate of vitamin D deficiency doubled in obese adults compared to those in the normal BMI range. Our finding of gender difference is in agreement with that of Maggio et al (2005), who showed that females had lower plasma 25(OH)D than did males. They hypothesized that females had decreased 25(OH)D earlier in life than did men and that skin thinning, which is a consequence of menopause and is age-related, is and skin color; increased skin pigmentation found in both of these groups can act as a natural sun block and reduce the UVB from penetrating the skin by up to 99% .…”

Section: Snp Genotypingsupporting

confidence: 92%

Vitamin D levels, vitamin D receptor polymorphisms and HOMA2 model in Cuban Americans, Haitian Americans, and African Americans with and without type 2 Diabetes

Shaban¹

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DEDICATIONI dedicate this dissertation to my father and mother, for without your stability and support throughout my life I wouldn't have made it this far.To my family in Kuwait, I thank you for all your trips to see me, support and encourage me. To my husband who gave me his unconditional support, and who has shown me that I am more than I think I can be. To my two beautiful God sent children whose time was stolen from them in order for me to attain a Ph.D. and to whom I shall forever be indebted.

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25(OH)D Serum Levels Decline With Age Earlier in Women Than in Men and Less Efficiently Prevent Compensatory Hyperparathyroidism in Older Adults

Abstract: These findings suggest that the age-associated fall of serum 25(OH)D starts earlier in women than in men and that higher levels of 25(OH)D are required in older compared to younger persons to avoid the age-associated compensatory hyperparathyroidism.

Cited by 74 publications

References 35 publications

Vitamin D deficiency is a problem for adult out-patients? A university hospital sample in Istanbul, Turkey

Vitamin D deficiency is a problem for adult out-patients? A university hospital sample in Istanbul, Turkey

Correlates of bone quality in older persons

Vitamin D levels, vitamin D receptor polymorphisms and HOMA2 model in Cuban Americans, Haitian Americans, and African Americans with and without type 2 Diabetes

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