275 Comparison between a Novel Phytase and a Commercial Phytase on Growth Performance and Bone Measurements in Diets Fed to Growing Pigs.

Alfonso, C J Munoz; Blavi, Laia; Broomhead, J. N.; Stein, Hans H

doi:10.1093/jas/sky073.272

Cited by 3 publications

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“…The corn-expressed phytase (GraINzyme, Agrivida Inc., Woburn, MA) tested in this current research has been shown to be safe and effective in poultry (Ligon, 2016) and contains an engineered Escherichia coli phytase called Phy02. GraINzyme (GZ) has been demonstrated to improve ADG, feed efficiency, bone mineralization and strength, and P digestibility when young pigs were fed reduced P and Ca diets (Lee et al, 2017;Blavi et al, 2018;Knapp et al, 2018aKnapp et al, , 2018bMunoz Alfonso et al, 2018). The objective of this study was to determine the efficacy of GZ phytase on the live performance, bone characteristics, and P digestibility of nursery pigs fed a reduced P and adequate Ca diet.…”

Section: Introductionmentioning

confidence: 99%

Effects of feeding corn-expressed phytase on the live performance, bone characteristics, and phosphorus digestibility of nursery pigs

Broomhead

Lessard

Raab

et al. 2018

Journal of Animal Science

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A 41-d feeding trial was conducted to determine the efficacy of a corn-expressed phytase (GZ; GraINzyme, Agrivida Inc., Woburn, MA) on the live performance, bone characteristics, and P digestibility of nursery pigs fed a reduced P diet. Weaned piglets (21 ± 3 d; n = 324) were acclimated on a common diet for 7 d (phase 1) before randomization into 54 single-sex pens (5 gilt and 4 barrow pens per treatment) containing 6 pigs (6.6 ± 1.2 kg) per pen. Six treatments were fed: positive control (PC; 0.4% or 0.32% aP for phase 2 or 3 and 4, respectively), negative control (NC; 0.15% reduction in aP), and 500, 1,000, 2,000, or 4,000 FTU per kg phytase from GZ added to NC in a 3-phase feeding program. Pigs were weighed on day 1, 14, 28, and 41, and feed disappearance recorded per phase. Apparent total tract digestibility (ATTD) of P was determined by feeding chromic oxide marker (day 28 to 35) and collecting fecal samples on day 35. On day 41, 4 pigs per pen were euthanized and metacarpal bones were collected to evaluate bone breaking strength (BBS) and ash. Data were analyzed using PROC GLM of SAS (block, sex, and treatment). Treatment least squares means were separated and linear and quadratic treatment effects evaluated. Other than feed efficiency (G:F) and day 15 to 28 ADFI, the pigs fed PC were superior (P < 0.05) to NC-fed pigs in all other variables. Pigs fed ≥500 FTU per kg phytase had increased (P < 0.05) ADG and ADFI compared to NC pigs and equivalent (P > 0.05) ADG and ADFI as PC pigs from day 0 to 41. Feeding ≥500 FTU per kg phytase resulted in higher (P < 0.05) ATTD of P than both NC and PC pigs and higher (P < 0.05) BBS and bone ash weight than NC. Pigs fed 1,000 or 2,000 FTU per kg phytase had equivalent (P > 0.05) BBS and bone ash weight compared to pigs fed PC diets. Feeding 4,000 FTU per kg phytase resulted in higher (P < 0.05) day 1 to 41 ADG, ATTD of P, and bone ash weight compared to feeding ≤1,000 FTU per kg phytase or PC diets. There were linear (P < 0.05) increases in ADG, ADFI, ATTD of P, BBS, and bone ash characteristics as GZ inclusion increased. In conclusion, ≥500 FTU per kg phytase from GZ improved growth, ATTD of P, BBS, and bone ash when added to a reduced P diet and 4,000 FTU per kg phytase increased growth greater than the PC treatment.

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Section: Introductionmentioning

confidence: 99%

Effects of feeding corn-expressed phytase on the live performance, bone characteristics, and phosphorus digestibility of nursery pigs

Broomhead

Lessard

Raab

et al. 2018

Journal of Animal Science

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Determining the phosphorus release of GraINzyme phytase in diets for nursery pigs

Becker

Wensley

DeRouchey

et al. 2021

Translational Animal Science

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The objective of this study was to determine the available P (aP) release curve for a new phytase source, GraINzyme Phytase (Agrivida Inc., Woburn, MA), which is expressed in corn containing an engineered Escherichia coli phytase called Phy02. Plant-expressed phytases are created by inserting phytase-encoding genes into plants resulting in their ability to produce seeds with increased concentrations of phytase. A total of 360 pigs (Line 200 × 400, DNA, Columbus, NE, initially 9.9 ± 0.19 kg) were used in a 21-d growth study. Pigs were weaned at approximately 21-d of age, randomly allotted to pens based on initial body weight (BW) and fed common starter diets. From d 18 to 21 post-weaning, all pigs were fed a diet containing 0.11% aP. On d 21 post-weaning, considered d 0 of the study, pens were blocked by BW and randomly allotted to 1 of 8 dietary treatments with 5 pigs per pen and 9 pens per treatment. Dietary treatments were formulated to include increasing aP derived from either an inorganic P source (0.11, 0.19, or 0.27% from monocalcium P) or increasing phytase (150, 250, 500, 1,000, or 1,500 FTU/kg). Diets were corn-soybean meal-based and contained 1.24% standardized ileal digestible (SID) Lys. On d 21 of the trial, 1 pig per pen (weighing closest to the mean pen BW) was euthanized and the right fibula was collected to determine bone ash using the non-defatted processing method. Overall (d 0 to 21), pigs fed increasing aP from inorganic P or phytase had increased (linear, P < 0.002) ADG, ADFI, and G:F (quadratic, P < 0.05). Bone ash weight (g) and percentage bone ash increased (linear, P < 0.001) with increasing inorganic P or added phytase. Based on the composition of the diets used in this study, the release equations developed for GraINzyme for ADG, G:F, bone ash weight, and percentage bone ash are: aP = (0.255 × FTU) ÷ (1299.969 + FTU), aP = (0.233 × FTU) ÷ (1236.428 + FTU), aP = (45999.949 × FTU) ÷ (462529200 + FTU), and aP = (0.272 × FTU) ÷ (2576.581 + FTU), respectively.

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Comparing the Efficacy of Varieties, Low and High Phytase-expressing Corn, at Equivalent Phytase Levels on Broiler Performance and Bone Ash

Dimas,

Sobotik,

House

et al. 2023

International J. of Poultry Science

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275 Comparison between a Novel Phytase and a Commercial Phytase on Growth Performance and Bone Measurements in Diets Fed to Growing Pigs.

Cited by 3 publications

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Effects of feeding corn-expressed phytase on the live performance, bone characteristics, and phosphorus digestibility of nursery pigs

Effects of feeding corn-expressed phytase on the live performance, bone characteristics, and phosphorus digestibility of nursery pigs

Determining the phosphorus release of GraINzyme phytase in diets for nursery pigs

Comparing the Efficacy of Varieties, Low and High Phytase-expressing Corn, at Equivalent Phytase Levels on Broiler Performance and Bone Ash

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