292 Dynamics of apoptotic activity during antiviral treatment of patients with chronic hepatitis C

Effect of antiviral therapy on circulating cytokeratin-18 fragments in patients with chronic hepatitis C

“…Kronenberger et al. [10] reported in 19 patients a correlation at baseline, which disappeared at the end of antiviral treatment which is in line with our data. This group found that the evolution of the aminotransferase activities and the evolution of the cytokeratin‐18 fragment levels differ during therapy.…”

Nucleos(t)ide analogue treatment reduces apoptotic activity in patients with chronic hepatitis B

“…4,5,15 In the present study, one quarter of the patients had high apoptosis levels and histological liver damage despite of low ALT levels supporting the concept that total cell death is underestimated by serum ALT activity.…”

“…4,5,16,17 We observed that fibrosis was significantly correlated with M30-apoptosis and M65-necrosis while ALT activity was not correlated with fibrosis. These results indicate that apoptosis may be involved in HBV-induced liver damage.…”

“…However, liver cirrhosis and hepatocellular carcinoma may develop in the absence of alanine aminotransferase (ALT) elevation. 2,4,5 The discrepancy between ALT activity and histological liver damage may be explained by cell death that occurs without ALT release. During apoptosis, cells typically die without membrane damage.…”

The effect of alanine aminotransferase dynamics on predicting sustained virological response in chronic hepatitis C virus infection

“…The mechanism of decline of ALT level is not clear, but it can be explained by a reduction in infected cells, a non-cytolytic cure, or cell removal irrelevant ALT dynamics. However, a decreased ALT level at early phase of treatment is not related with apoptotic acitivity 15. Theoretically, the rapid declines in ALT may reflect a rapid decrease of ongoing inflammation in the same manner as removal of the virus.…”