292 Physiologic and Biochemical Profile of Clinically Rejected Lungs on a Normothermic Ex Vivo Lung Perfusion Platform

George, Timothy J.; Arnaoutakis, George J.; Beaty, Claude A.; Jandu, Simran K.; Berkowitz, Dan E.; Santhanam, Lakshmi; Shah, Ashish S.

doi:10.1016/j.healun.2012.01.300

The Journal of Heart and Lung Transplantation

2012

DOI: 10.1016/j.healun.2012.01.300

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292 Physiologic and Biochemical Profile of Clinically Rejected Lungs on a Normothermic Ex Vivo Lung Perfusion Platform

Timothy J. George

George J. Arnaoutakis

Claude A. Beaty

et al.

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Ex Vivo Lung Perfusion

Roman

Nair²,

Tsui³

et al. 2013

Transplantation

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There is a critical mismatch between the number of donor lungs available and the demand for lungs for transplantation. This has created unacceptably high waiting-list mortality for lung transplant recipients. Currently (2012) in the United Kingdom, there are 216 patients on the lung transplant waiting list and 17 on heart and lung transplant list. The waiting times for suitable lungs average 412 days, with an increasing mortality and morbidity among the patients on the lung transplant list. Ex vivo lung perfusion (EVLP) has emerged as a technique for the assessment, resuscitation, and potential repair of suboptimal donor lungs. This is a rapidly developing field with significant clinical implications. In this review article, we critically appraise the background developments that have led to our current clinical practice. In particular, we focus on the human and animal experience, the different perfusion-ventilation strategies, and the impact of different perfusates and leukocyte filters. Finally, we examine EVLP as a potential research tool. This will provide insight into EVLP and its future development in the field of clinical lung transplantation.

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Ex Vivo Lung Perfusion

Roman

Nair²,

Tsui³

et al. 2013

Transplantation

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292 Physiologic and Biochemical Profile of Clinically Rejected Lungs on a Normothermic Ex Vivo Lung Perfusion Platform

Cited by 1 publication

References 30 publications

Ex Vivo Lung Perfusion

Ex Vivo Lung Perfusion

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