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Abstract

Streptococcus pneumoniae causes pneumonia and bacterial meningitis, and bacteremia in children. Irvingia sp. or African Bush Mango has nutritional and health benefits and their leaf extracts and other parts have been documented to possess antimicrobial activity, which can be exploited to ameliorate the scourge of antibiotics resistance. In this study, 30 out of 35 albino rats were intraperitoneally challenged with S. pneumoniae, followed by oral administration of leaf extract of Irvingia sp. The rats exhibited sluggishness, ruffled fur, inappetence and hunch back posture, but recovered from the fourth day after oral administration of Irvingia sp. leaf extract. The mean body weights of the rats were 175±1.9 g and 176±1.5 g in the test and the control groups, respectively on the first day of the experiment. The mean body weight of the test group (173±7 g) was lower than the control group (182±40.5 g) on the sixth day of post-infection (P = 0.65). The mean value of food intake by the rats for base line (27.95±5.3g) was higher than the third day (17.35±2.2g) corresponding with inappetence observed in the rats in the test group.

Molecular identification and in vitro bioactivities of silver nanoparticles (AgNPs) biosynthesized by an endophytic fungus, Plectosphaerella oligotrophica, isolated from Anaphalis contorta

“…The antifungal, antibacterial, and antioxidant activities of the P. oligotrophica and AgNPs were evaluated to assess their bioactive properties. (Pei et al 2019). Five days old 9 mm mycelial plugs of both the pathogen and P. oligotrophica were placed on PDA petriplates in such a way that the pathogens were inoculated at the centre of each plate, and P. oligotrophica on both sides of the pathogen 2 cm apart and incubated at 28±1°C.…”