2D and 3D Qsar Studies on Captropril Derivatives as Potent Angiotensin-Converting Enzyme (ACE) Inhibitors

Abstract

Angiotensin Converting Enzyme (ACE), a metallo-peptidase is the best known important drug target in the treatment of hypertension and responds to broad range ACE inhibitors such as captropril and lisinopril. In this study, the 2D and 3D QSAR methods are used to study the correlation between the molecular properties and the ACE inhibitory activities on a series of 28 ACE