3:09 PM Abstract No. 34 Neutrophil to lymphocyte ratio (NLR) predicts early tumor progression in transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC): assessment by mRECIST

Watchmaker, Jennifer M.; Cruz, Jeffrey C.; Albin, Matthias M.; Fritsche, Micah R.; Su, J.; Fleming, J; Alexopoulos, Sophoclis P.; Geevarghese, Sunil K.; Baker, Jennifer; Borgmann, T.; Banovac, Filip; Brown, Daniel B.

doi:10.1016/j.jvir.2018.01.042

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“…Many efforts have been made to improve the prognosis of HCC and the main therapies include surgical resection, liver transplantation, chemotherapy, and locoregional treatment [ 17 ]. Transcatheter arterial chemoembolization (TACE) is a common treatment strategy for patients with unresectable HCC and often provides satisfying outcomes [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Transcatheter arterial chemoembolization combined with Hippo/YAP inhibition significantly improve the survival of rats with transplanted hepatocellular carcinoma

Quan

Li²,

Zhu

et al. 2021

Lipids Health Dis

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Background This study aimed to explore the effect of inhibiting the Hippo/Yes-associated protein (YAP) signaling pathway on the outcomes of transcatheter arterial chemoembolization (TACE) in treating transplanted hepatocellular carcinoma (HCC). Methods A transplanted HCC rat model was established. Then, rats were randomly divided into four groups: Sham, TACE, verteporfin (inhibitor of Hippo/YAP), and TACE+verteporfin. Lent-OE-YAP was transfected into rats to overexpress YAP in vivo. After treatments, morphological changes, tumor weight, and the overall survival of rats in different groups were analyzed. Real-time PCR, immunohistochemistry staining, and Western blotting were used to determine the expression of factors related to the Hippo/YAP signaling pathway. Results Tumor weight and tissue lesions in the TACE and verteporfin groups were significantly reduced compared with the Sham group. Verteporfin significantly decreased tumor weight after TACE treatment. In addition, verteporfin significantly improved the overall survival of rats with transplanted HCC after TACE treatment. Compared with the Sham group, both TACE and verteporfin groups exhibited significantly decreased expression of macrophage-stimulating (MST)1, MST2, long-acting thyroid stimulator 1, transcriptional co-activator with PDZ-binding motif (TAZ), Yes-associated protein (YAP), TEA domain transcription factor (TEAD)1, TEAD2, TEAD3, and TEAD4. TACE plus verteporfin significantly enhanced the downregulation of effectors in the Hippo/YAP signaling pathway and decreased tumor size, while the overexpression of YAP exerted opposite effects. Conclusion The inhibition of the Hippo/YAP signaling pathway via verteporfin significantly improved the outcomes of TACE in treating transplanted HCC.

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Section: Introductionmentioning

confidence: 99%