3,4 Methylenedioxymethamphetamine-induced conditioned place preference (CPP) is mediated by endocannabinoid system

Braida, Daniela; Iosuè, Stefania; Pegorini, Simona; Sala, Mariaelvina

doi:10.1016/j.phrs.2004.07.009

Cited by 54 publications

(25 citation statements)

References 49 publications

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“…These findings were interpreted to indicate synergism between the reinforcing effects of cannabinoids and MDMA and a reduction in the motivational value of MDMA by CB 1 blockade (Braida and Sala, 2002). In another study, the authors found that SR141716 blocked MDMA-induced CPP (Braida et al, 2005). Amphetamine-induced long-term synaptic depression in the amygdala could be blocked by the CB 1 antagonist AM251, mimicked by the agonist WIN 55,212-2, and occluded by the transport inhibitor AM404, suggesting that amphetamine-induced LTD and related behavioral effects may be mediated via endocannabinoid release (Huang et al, 2003).…”

mentioning

confidence: 96%

The Endocannabinoid System as an Emerging Target of Pharmacotherapy

2006

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confidence: 96%

The Endocannabinoid System as an Emerging Target of Pharmacotherapy

2006

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“…Primates (Beardsley et al, 1986;Fantegrossi et al, 2002Fantegrossi et al, , 2004Lamb and Griffiths, 1987;Lile et al, 2005), rats (Braida and Sala, 2002;Braida et al, 2005;Cornish et al, 2003;Daniela et al, 2004;Schenk et al, 2003), and mice (Trigo et al, 2006) learn to perform an operant response to obtain an infusion of MDMA, which suggests the addictive potential of this drug.…”

Section: Introductionmentioning

confidence: 99%

“…This procedure is based on the fact that the pairing of neutral distinctive environmental stimuli with a drug (primary reward) results in an acquired preference for those specific stimuli (secondary or conditioned reward). The administration of MDMA produces CPP in rats Bilsky et al, 1990Bilsky et al, , 1998Braida et al, 2005;Herzig et al, 2005;Marona-Lewicka et al, 1996;Meyer et al, 2002;Schechter, 1991) and mice (Robledo et al, 2004a, b;Salzmann et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Rewarding Effects and Reinstatement of MDMA-Induced CPP in Adolescent Mice

Daza-Losada

Couto

Manzanedo

et al. 2007

Neuropsychopharmacol

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Although the rewarding effects of 3,4-methylenedioxy-metamphetamine (MDMA) have been demonstrated in self-administration and conditioned place preference (CPP) procedures, its addictive potential (ie, the vulnerability to relapse, measured by its ability to induce reinstatement of an extinguished response), remains poorly understood. In this study, the effects of MDMA (5, 10, and 20 mg/kg) on the acquisition, extinction and reinstatement of CPP were evaluated in mice, using two different protocols during acquisition of CPP. In the first experiment, animals were trained using a two-session/day schedule (MDMA and saline for 4 consecutive days), whereas in the second experiment, they were trained using an alternating day schedule (MDMA and saline each 48 h). After extinction, the ability of drug priming to reinstate CPP was evaluated. In Experiment 1, MDMA did not significantly increase the time spent in the drug-paired compartment during the post-conditioning (Post-C) test, although the preference was evident a week afterwards, lasting between 2 and 21 weeks. No reinstatement was observed after MDMA priming. In Experiment 2, all doses produced CPP in Post-C, which lasted between 1 and 4 weeks. MDMA induces reinstatement at doses up to 4 times lower than those used in conditioning. The analyses of brain monoamines revealed that the daily schedule of treatment induces a non-dose-dependent decrease in dopamine and serotonin (5-HT) in the striatum, whereas the alternating schedule produces a dose-dependent decrease of 5-HT in the cortex. These results demonstrate that MDMA produces long-lasting rewarding effects and reinstatement after extinction, suggesting the susceptibility of this drug to induce addiction.

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“…More recently, it has been reported that naive monkeys can learn to self-administer THC (Justinova et al 2003). Interactions between the cannabinoid system and MDMA-rewarding effects have been suggested in studies showing that pre-treatment with the cannabinoid CB1 receptor antagonist, rimonabant blocked CPP induced by intracerebroventricular (ICV) injections of MDMA in rats (Braida et al 2005). Using the ICV drug selfadministration paradigm in rats, it was also shown that rimonabant increased, and the CB1 agonist CP 55,940 lowered the mean number of infusions of MDMA (Braida and Sala 2002).…”

Section: Introductionmentioning

confidence: 99%