3, 4-seco-Labdane diterpenoids from the leaves of Callicarpa nudiflora with anti-inflammatory effects

Wang, Honggang; Luo, Fukang; Lei, Xiang; Yao, Yun-Da; Liao, Guochao; Liu, Zhongqiu; Jiang, Zhi‐Hong; Zhou, Hua; Wu, Peng

doi:10.1016/s1875-5364(19)30085-8

Cited by 7 publications

(11 citation statements)

References 9 publications

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“…nudiflora has a strong inhibitory effect on bacterial and fungal diseases in clinical [ 12 ]. It is effective to improve microcirculation, increase local blood flow, promote inflammation rehabilitation, promote epithelial regeneration and repair diseased tissue [ 12 , 13 , 14 ], displaying adequate anti-cervicitis effects. However, the active substances of C .…”

Section: Discussionmentioning

confidence: 99%

“…The results showed that compounds 1 and 2 exhibited the best anti-inflammatory activities. Recently, Wang et al [ 14 ] also isolated several diterpenoids from the leaves of C. nudiflora which displayed potent anti-inflammatory effects. These results indicated that diterpenoids might be the active substances of C. nudiflora.…”

Section: Discussionmentioning

confidence: 99%

“…C. nudiflora is a plant that can grow up to shrub or small tree and is mainly distributed in Hainan, Guangdong, and Guangxi Province, China [ 11 ]. As a medicinal plant, C. nudiflora has multiple pharmacological effects including anti-inflammatory, antibacterial, and hemostatic effects [ 12 , 13 , 14 ]. The extract of its aerial parts has been made into many clinical preparations such as Luohuazizhu tablet, Luohuazizhu capsule, Luohuazizhu suppository [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Active Substances from Callicarpa nudiflora Exert Anti-Cervicitis Effects and Regulate NLRP3-Associated Inflammation

et al. 2021

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Luohuazizhu suppository is a Traditional Chinese Medicine used in clinic to treat cervicitis, which is prepared from Callicarpa nudiflora Hook. et Arn (C. nudiflora), an herbal Chinese medicine named Luohuazizhu. This study aimed to figure out the active constituents of C. nudiflora and the potential mechanism for its anti-cervicitis effect. The ethanol extract in C. nudiflora (CNE) and the different fractions of CNE extracted by petroleum ether (CNE-p), dichloromethane (CNE-d), and n-butanol (CNE-b) were tested in vivo for their anti-cervicitis effects. Then the isolated compounds from the CNE-p were tested in vitro for their anti-inflammatory activities. The results displayed that CNE-p, CNE-d, and CNE-b exhibited adequate anti-cervicitis effects, with CNE-p showing the highest efficacy. Further experiment demonstrated that CNE-p could significantly inhibit the expression of NLRP3 in vitro. Six diterpenoids obtained from the CNE-p showed the ability to regulate inflammatory factor levels in vitro. Among these compounds, compounds 1 (callicarpic acid A) and 2 (syn-3,4-seco-12S-hydroxy-15,16-epoxy-4(18),8(17),3(16),14(15)-labdatetraen-3-oic acid) were the most effective agents, and they also inhibited the expression level of NLRP3 in vitro. The results confirmed that C. nudiflora has significant anti-cervicitis effects and the diterpenoids were most likely to be its active components. These data provide scientific support for the clinic usage of Luohuazizhu suppository and the development of new agents in treating cervicitis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Active Substances from Callicarpa nudiflora Exert Anti-Cervicitis Effects and Regulate NLRP3-Associated Inflammation

et al. 2021

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“…[1] The dried leaves of C. nudiflora were used as a folk medicine for antiphlogosis, hemostasis and antibiosis since ancient times, which has been confirmed by modern research. [2][3][4] The aqueous extracts of C. nudiflora have been developed into Luo-hua-zi-zhu Tablets and Capsules, recorded in Chinese Pharmacopoeia (2020 edition) and used for bacterial infections of the respiratory and gastrointestinal tract. [5] The C. nudiflora-derived suppository has been applied to treat cervicitis in clinic, which helps to relieve mild cervical erosion, and reduce cervical congestion and edema.…”

Section: Introductionmentioning

confidence: 99%

Chemical Profiling and Quality Evaluation of Callicarpa Nudiflora from Different Regions in China by UPLC‐QTOF‐MS Fingerprint

Jia

zhang

et al. 2022

Chemistry & Biodiversity

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Callicarpa nudiflora, belonging to the family Verbenaceaae, is wildly used as a traditional Chinese herbal medicine (Luo-hua-zi-zhu) for hemostasis, antibiosis and antiphlogosis in clinic. However, the underlying chemical basis of C. nudiflora for the significant effects remains obscure. Hence, an ultra-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry method was established for the characterization of multi-constituents in C. nudiflora. As a result, 57 chemical compounds were identified based on their retention times, accurate masses and MS/MS data, and 20 of them were uncovered for the first time in C. nudiflora. In addition, an optimized UHPLC fingerprint analysis, combined with chemometrics including similarity analysis, principal component analysis and partial least squares-discriminant analysis was developed for quality assessment and origin discrimination of C. nudiflora. Multivariate data analysis revealed the resemblances and differences of C. nudiflora related to regions, while partial least squares-discriminant analysis screened nine characteristic markers including luteoloside, acteoside, luteolin-4'-O-β-D-glucopyranoside, pachypodol, isoquercitrin, nudifloside, 5,7,3',4'-tetrahydroxy-8-methoxy-6-C-β-D-glucopyranosylflavone, 7α-acetoxysandaracopimaric acid and sandaracopimaric acid which contributed the most to the classification. This was the first report on the comprehensive profiling of chemical components in C. nudiflora, which helped to uncover the material basis of C. nudiflora and possess potential value for quality evaluation and clinical application purpose.

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“…4,5 However, to the best of our knowledge, the constituents of C giraldii have not been investigated. As a part of our ongoing research on anti-inflammatory compounds isolated from Callicarpa , 6 nine known compounds have been isolated from the methanol extracts of the leaves and stems of C giraldii by various chromatographic methods. The structures were identified by comparing their spectroscopic data with those reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

Chemical Constituents of Callicarpa giraldii and Their Anti-Inflammatory Activity

Yi¹,

Wu²,

Xu³

et al. 2021

Natural Product Communications

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Callicarpa giraldii (family Verbenaceae) has many medical properties and is commonly used in traditional Chinese medicine. However, its chemical constituents have not been investigated. In this study, nine compounds present in the leaves and stems were isolated and characterized. These were negundonorin B (1), lupeol (2), erythrodiol (3), isoacteoside (4), forsythoside B (5), dibutyl phthalate (6), verbascoside (7), poliumoside (8), and 3-methoxy-4-hydroxybenzaldehyde (9). The structures were identified by comparison of their NMR data with those reported in the literature. The anti-inflammatory effects of compounds 1-6 were tested on lipopolysaccharide-stimulated RAW264.7 macrophages. Several compounds showed significant ( p < .05) inhibitory effects.

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3, 4-seco-Labdane diterpenoids from the leaves of Callicarpa nudiflora with anti-inflammatory effects

Cited by 7 publications

References 9 publications

Active Substances from Callicarpa nudiflora Exert Anti-Cervicitis Effects and Regulate NLRP3-Associated Inflammation

Active Substances from Callicarpa nudiflora Exert Anti-Cervicitis Effects and Regulate NLRP3-Associated Inflammation

Chemical Profiling and Quality Evaluation of Callicarpa Nudiflora from Different Regions in China by UPLC‐QTOF‐MS Fingerprint

Chemical Constituents of Callicarpa giraldii and Their Anti-Inflammatory Activity

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