3 T homogeneous static magnetic field of a clinical MR significantly inhibits pain in mice

László, J.; Gyires, Klára

doi:10.1016/j.lfs.2008.10.009

Cited by 28 publications

(20 citation statements)

References 59 publications

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“…No data were published about the gradient. According to recent exposure assessments, the stray SMF in the vicinity of MRI devices can reach up to 3.5 T/m [Crozier et al, 2007;Capstick et al, 2008;László and Gyires, 2008]. In our studies, the gradient field was more than tenfold higher than that in the case of iSMF1, about the same for iSMF2, and an order of magnitude smaller for iSMF3, therefore, these values of the magnetic gradient were suitable to characterize the occurrence of SMFs at MRI devices.…”

Section: Discussionmentioning

confidence: 99%

Effects of homogeneous and inhomogeneous static magnetic fields combined with gamma radiation on DNA and DNA repair

Kubinyi

Zeitler

Thuróczy

et al. 2010

Bioelectromagnetics

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The aim of this study was to reveal whether static magnetic fields (SMFs) influence the repair of radiation-damaged DNA on leukocytes or has any effect on DNA. After 4 Gy of (60)Co-gamma irradiation, some of the samples were exposed to inhomogeneous SMFs with a lateral magnetic flux density gradient of 47.7, 1.2, or 0.3 T/m by 10 mm lateral periodicity, while other samples were exposed to homogeneous SMF of 159.2 +/- 13.4 mT magnetic flux density for a time period of 0.5 min, 1, 2, 4, 6, 18, 20, or 24 h. Another set of samples was exposed to the aforementioned SMFs before gamma irradiation. The following three groups were examined: (i) exposed to SMF only, (ii) exposed to SMF following irradiation by (60)Co-gamma, and (iii) exposed to SMF before (60)Co-gamma irradiation. The analysis of the DNA damage was made by single-cell gel electrophoresis technique (comet assay). Statistically significant differences were found at 1 h (iSMF), 4 h (hSMF), and 18 h (hSMF) if samples were exposed to only SMF, compared to control. When the SMF exposure followed the (60)Co-gamma irradiation, statistically significant differences were found at 1 h (iSMF) and 4 h (hSMF). If exposure to SMF preceded (60)Co-gamma irradiation, no statistically significant difference was found compared to 4 Gy gamma-irradiated group.

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Section: Discussionmentioning

confidence: 99%

Effects of homogeneous and inhomogeneous static magnetic fields combined with gamma radiation on DNA and DNA repair

Kubinyi

Zeitler

Thuróczy

et al. 2010

Bioelectromagnetics

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“…Not only because several cytokines, such as pro-inflammatory cytokines: IL-6 [28][29][30][31][32][33], IL-8 [29,31,34], tumor necrosis factor-α (TNF-α) [29,32,33,35], and anti-inflammatory cytokine IL-10 [29,32,35], were shown to have a significant contribution to either the development or the evolution of pathological conditions such as EAE or MS, but the release of these cytokines was also investigated under SMF-exposure. It is conceivable that the self-motion of animals in a whole-body SMF may generate currents especially, when animals are free to move as discussed to some details in [25,26,36]. For a detailed analysis, see [37].…”

Section: Discussionmentioning

confidence: 99%

The effect of whole-body, repetitive, inhomogeneous static magnetic field-exposure on the symptoms of experimental autoimmune encephalomyelitis in mice

László

Solténszky

Pórszász

et al. 2014

Journal of Complementary and Integrative Medicine

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Experimental autoimmune encephalomyelitis (EAE) is a model for human multiple sclerosis (MS) in rodents. Static magnetic field (SMF)-exposure was shown to be beneficial in specific cases of inflammatory background, where it suppresses symptoms. The null-hypothesis was that animals with induced EAE exposed to SMF would show different seriousness of symptoms, than those in the sham-exposed control group. Three replicated series of repetitive, 30 min/day whole-body exposure to SMF with 477 mT peak-to-peak magnetic induction and 48 T/m lateral induction gradient was tested on female CSJLF1 mice with a mild, mouse spinal cord homogenate emulsion-induced EAE. Conventional scores of the animal response to EAE were compared between sham- and SMF-exposed groups of animals. Following pilot test we used 18 animals per group. Primary outcome measure was the daily group average of standard EAE scores. Results show that SMF-exposure has a strong, reproducible, and significantly beneficial effect up to 51.82% (p<0.001) over sham-exposure on the symptoms of EAE in the course of the 25 days of the experiment. This study aimed to build experimental research foundation for a later therapy option by applying SMF-exposure in the clinical management of MS.

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“…Previously, the beneficial effects of magnetic fields on inflammation [2], osteoporosis [3], wound healing [4], and pain reduction [5] have been demonstrated by a plenty of intriguing studies using laboratory animals in vivo. Meanwhile, the frequency of exposure to SMFs has also increased rapidly, such as magnetic resonance imaging (MRI) and nuclear magnetic resonance (NMR) [6], which have been used in hospitals as noninvasive diagnostic tools.…”

Section: Introductionmentioning

confidence: 99%

Exposure to Static Magnetic Fields Affects Insulin Secretion in INS Cells

Mao

Guo

Wang

et al. 2015

Lecture Notes in Electrical Engineering

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The exposure to static magnetic fields (SMFs) has rapidly increased and is recently accompanied with the wide use of more and more electrical appliances. Although few researches have been reported on other types of magnetic fields that may have the effects on clinical therapy of diseases, it is rarely seen reports on the effects of moderate static magnetic fields on human health. In this study, in order to evaluate the influence of exposure to moderate static magnetic fields on biological systems, we cultured the INS-1 under exposure to moderate intensity of 400 mT and sham conditions for different times from 6 to 18 h, insulin secretion to medium and mRNA expression will be tested after exposure. Insulin secretion has significantly increased after exposed to SMFs with moderate intensity of 400 mT for 18 h compared with the sham condition. Furthermore, similar to the insulin secretion, insulin 1 and insulin 2 mRNA expression also increased after exposure. These results suggest that exposure to SMFs at 400 mT position for specific times might have positive stimulation in both insulin secretion and insulin mRNA expression, and these will be used hopefully in further investigations in vitro, even in the therapy clinically.

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3 T homogeneous static magnetic field of a clinical MR significantly inhibits pain in mice

Cited by 28 publications

References 59 publications

Effects of homogeneous and inhomogeneous static magnetic fields combined with gamma radiation on DNA and DNA repair

Effects of homogeneous and inhomogeneous static magnetic fields combined with gamma radiation on DNA and DNA repair

The effect of whole-body, repetitive, inhomogeneous static magnetic field-exposure on the symptoms of experimental autoimmune encephalomyelitis in mice

Exposure to Static Magnetic Fields Affects Insulin Secretion in INS Cells

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