302 Local allergen challenge increases bronchovascular permeability in asthmatics

Grönneberg, R.; Gilljam, Hans; Salomonsson, P.; Andersson, Olof; Billing, Bo; Enander, I.; Persson, C. G. A.

doi:10.1016/0091-6749(91)91585-h

Cited by 2 publications

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“…The distinction between pulmonary microvascularalveolar indices and bronchial microvascular-mucosal indices is particularly important in studies of bronchial diseases such as asthma (fig 6). In accordance with the thought that the large plasma proteins may better reflect bronchial mucosal exudation, GRONNEBERG et al [26] have demonstrated allergen-induced exudation of fibrinogen (MW 340000) rather than albumin (MW 69000) in BAL fluids from asthmatic subjects. In BAL fluid obtained from symptomatic non-allergic asthma MArrou et al [27] have demonstrated elevated levels of fibronectin (MW >400000) and V AN DE GRAAF et al [28] have found reduced levels of large plasma proteins in BAL fluids obtained after prolonged treatment of asthmatic subjects with an inhaled glucocorticoid.…”

Section: Plasma Exudation Into the Lumen As An Index Of Mucosal Infla...mentioning

confidence: 65%

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Plasma exudation in the airways: mechanisms and function

Persson

1991

Eur Respir J

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Inflammatory challenges of tracheobronchial and nasal mucosa produce prompt extravasation or exudation of plasma from the well developed microcirculation just beneath the epithelial base. Plasma exudation is not an exaggeration of the normal capilliary exchange of fluid and solutes but a specific inflammatory response of post-capilliary venules. The exuded plasma may not produce oedema. By a rapid, undirectional, unfiltered and yet non-injurious process, plasma exudates cross the mucosal lining to appear on the airway surface at the site of challenge. In vitro data suggests the possibility that a slightly increased hydrostatic pressure moves the acellular exudate through valve-like openings between epithelial cells. By the venular-mucosal exudation mechanism all the potent protein systems of circulating plasma will operate in respiratory defence on the surface of an intact mucosa. A further inference is that exudative indices obtained from the airway surface quantitatively reflect the intensity and time course of mucosal/submucosal inflammatory processes. Irrespective of which particular cellular mechanism happens to fuel the inflammation. Mucosal exudation of plasma characteristically occurs in health and disease also when there is no airway oedema, no epithelial disruption, and no increased absorbtion ability. However, exuded plasma and its derived peptide mediators potentially contribute to several pathophysical and pathophysiological characteristics of inflammatory airway diseases.

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Section: Plasma Exudation Into the Lumen As An Index Of Mucosal Infla...mentioning

confidence: 65%

“…The small plasma protein albumin is the dominating protein in normal alveolar and bronchial lining fluids. Hence, although it may be increased in asthma (26,29) albumin may not be well suited as an exudative index in BAL fluid.…”

Section: Plasma Exudation Into the Lumen As An Index Of Mucosal Infla...mentioning

confidence: 99%