3020 Insc mutation within Card15/Nod2 is associated with increased gastrointestinal permeability: A family study on crohns disease

Buehner, Sabine; Schmidt, Hartmut; Buening, Carsten; Kling, Kerstin; Herrmann, Dana; Genschel, Janine; Krueger, S.; Dignaß, Axel; Reinisch, Walter; Kuechler, Ingeborg; Lochs, Herbert

doi:10.1016/s0016-5085(03)80239-1

Cited by 3 publications

(2 citation statements)

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“…Intestinal epithelium also functions as a frontier barrier protecting the mucosal integrity, which physically inhibits the penetration of harmful substances from the external environment . The abnormal epithelial barrier function, also called leaky gut, is associated with many diseases and complications, including inflammatory bowel disease (IBD), metabolic syndrome, and autoimmune disorders . Thus, a proper intestinal barrier is essential for health.…”

Section: Introductionmentioning

confidence: 99%

Purple Potato Extract Promotes Intestinal Epithelial Differentiation and Barrier Function by Activating AMP‐Activated Protein Kinase

Sun

Navarre³

et al. 2018

Molecular Nutrition Food Res

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Section: Introductionmentioning

confidence: 99%

Purple Potato Extract Promotes Intestinal Epithelial Differentiation and Barrier Function by Activating AMP‐Activated Protein Kinase

Sun

Navarre³

et al. 2018

Molecular Nutrition Food Res

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“…Together, the occurrence of epithelial barrier dysfunction before the outbreak of the inflammatory response supports the hypothesis of epithelial defects as etiological factors in IBD pathogenesis. GWAS studies identified genes linked to altered barrier function to be associated to IBD; including genetic variants of CARD15/NOD2 gene, resulting in severe forms of CD (D'Inca et al, 2006;Buhner et al, 2006). In fact, several genes relevant to epithelial barrier function have been categorized as IBD loci, such as HFN4, CDH1 and LAMB1 in UC (Consortium et al, 2009).…”

Section: Barrier Dysfunction In Ibdmentioning

confidence: 99%

The epithelium takes the stage in asthma and inflammatory bowel diseases

López-Posadas,

Bagley,

Pardo-Pastor

et al. 2024

Front. Cell Dev. Biol.

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The epithelium is a dynamic barrier and the damage to this epithelial layer governs a variety of complex mechanisms involving not only epithelial cells but all resident tissue constituents, including immune and stroma cells. Traditionally, diseases characterized by a damaged epithelium have been considered “immunological diseases,” and research efforts aimed at preventing and treating these diseases have primarily focused on immuno-centric therapeutic strategies, that often fail to halt or reverse the natural progression of the disease. In this review, we intend to focus on specific mechanisms driven by the epithelium that ensure barrier function. We will bring asthma and Inflammatory Bowel Diseases into the spotlight, as we believe that these two diseases serve as pertinent examples of epithelium derived pathologies. Finally, we will argue how targeting the epithelium is emerging as a novel therapeutic strategy that holds promise for addressing these chronic diseases.

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Epithelial Barrier Dysfunction in Disease

Pardo-Pastor,

López Posadas,

Ortiz Zapater

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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3020 Insc mutation within Card15/Nod2 is associated with increased gastrointestinal permeability: A family study on crohns disease

Cited by 3 publications

References 0 publications

Purple Potato Extract Promotes Intestinal Epithelial Differentiation and Barrier Function by Activating AMP‐Activated Protein Kinase

Purple Potato Extract Promotes Intestinal Epithelial Differentiation and Barrier Function by Activating AMP‐Activated Protein Kinase

The epithelium takes the stage in asthma and inflammatory bowel diseases

Epithelial Barrier Dysfunction in Disease

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