327 Antenatal Factors Associated with Developmental Delay in Moderately Preterm-Born Children, Results of a Cohort Study

Abstract

AbstractsMethods Participants. 362 infants aged 10-24 months, with at least one of: weight < 1500g, < 34 completed weeks gestational age, 5-min Apgar < 7, HIE. Children with impairments preventing fair assessment by ERIC were excluded. Parents/caregivers completed ERIC at home before administration of the Cognitive Scale of the Bayley Scales of Infant Development III. Delay was defined as a prematurity-corrected Bayley score < 80 (Moore et al, 2011 James Cook University, Middlesbrough, UK Background The Cryotherapy for Retinopathy of Prematurity Cooperative Group showed that the severity of ROP was a marker for functional disability at 5.5 years in infants ≤1250 g BW who were born in the late 1980s. Objective To determine whether severe ROP remains a strong predictor of visual and non-visual disabilities at age 5 years in infants ≤1250 g BW who were enrolled in the CAP trial between 1999 and 2004.Methods 5-year follow up of 1580 surviving CAP children with known ROP status. Severe ROP was defined as stage 4 or 5 disease or receipt of retinal therapy in at least one eye. Outcomes were disabilities in 6 domains, and including cognitive impairment (Full Scale IQ< 70), motor impairment (GMFCS level 2-5), deafness and blindness. Odds ratios were adjusted for antenatal steroids, gestational age, sex, multiple birth, and mother's education. Results There were 94 survivors with and 1486 without severe ROP. Rates of visual and non-visual disabilitites were significantly higher in children with severe ROP (Table 1).