2022
DOI: 10.1227/neu.0000000000001880_335
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335 Low Frequency Oscillations in the Ventral Nucleus Accumbens Region Guides Brain Responsive Neurostimulation for Loss of Control Eating: An Initial Review of the BITES Trial

Abstract: INTRODUCTION:Loss of control (LOC) eating is pervasive in eating disorders and obesity. The presence of this phenotype appears to predict treatment-resistance, including gastric bypass surgery. Brain-responsive neurostimulation guided by low frequency changes in the nucleus accumbens (NAc-RNS) was previously found to block LOC eating behavior in mice. Following this novel preclinical work, the U.S. Food and Drug Administration approved an Investigational Device Exemption for a first-in-human study.METHODS:Two … Show more

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