34 Deficiency of Late Complement Factors With Recurrent Meningococcal Septicaemia

Abstract

e l a TIMONE -Marseille -France .SQrum immunoglobulin t i t e r s using continuous flow liquid immunonephelometry i n 62 patients with A L L gave the following results :1. Before therapy, IgM values were elevated whereas those of I g A and I g G were within normal limits.2. During induction therapy, a l l three Ig classes were temporarily decreased. .During the remission period, Ig G levels were normal, however the distribution curve showed the patient populations in vhic the larger gmup had I g G values i n f e r i o r the normal mean value. I g A values were clearly decreased, where as those of Ig M were normal. GRAFT VERSUS HOST ( G V H ) REACTIOP~ UNIFES-TED AS TOXIC EPIDERh'.AL FECROLYSIS (TEN)IN A CBILC YIITH ACUTE LEUF3L;IA A.I.Berke1, K . T l n a z t e o e . H a c e t t e p e U n i v . , I n s t . o f C h i l d H e a l t h , K a c e t t e p e C h i l d . Hosp.,Ankara,Turkey P a t i e n t s w i t h d e f i c i e n t c e l l m e d i a t e d i m u n i t y l e v e l o p GVH r e a c t i o n a f t e r a d m i n i s t r a t i o n o f i m ul o l o g i c a l l y c o a p e t e n t c e l l s ( i . e . b o n e marrow o r ~r g a n g r a f t s o r b l o o d t r a n s f u s i o n s ) .A f a t a l GVI: 6 i s e a s e was o b s e r v e d i n a 5 y e a r ) I d n a l e w i t h a c u t e l e u k e m i a who h a s b e e n t r e a t e d -i t h c o r t i c o s t e r o i d s , 6 ~e r c a p t o p u r i n e , and b l o o d t r a n s f u s i o n s . A t y p i c a l p i c t u r e o f TEPi ( i n t e n s e e r y t -? e m a , b u l l o u s l e s i o n s , a p o s i t i v e N i k o l s k y ' s s i g n ) s a s s e e n 7 weeks a f t e r t h e d i a g n o s i s o f l e u k e c i a . Z u l t i p l e s k i n b i o p s i e s r e v e a l e d a c u t e e p i d e r x a l necr o l y s i s w i t h a r e a s o f c l e a v a g e i n t h e a a l p i g h i a n :one and f o c a l a i n t l e c e l l n e c r o b i o s i s w i t h i n t r a ~o i t k e l i a l s a t e l l i t e 1yrr.phocytes. T h e r e cas e l s o x l l d a e r i v a s c u l e r and p e c i i a d n e x a l c u f f i n g c o n s i s t i n g sf l y m p h o c y t e s and p l a s z a c y t o i d t y p e o f c e l l s . T h e s e f i r d i c y s , e s p e c i z l l y s i n g l e c e l l a y s k e r a t o s i s and i e c r o o i o s i s e e r e c o n s i s t e n t a i t h GVH r e a c t i o n as r~o s t l y d e s c r i b e d i n p a t i e n t s a f t e r a l l o g e n e i c bone t a r r o w t r a n s p l a n t a t i o n , 33 EXCHAINGE TRANSFUSION AND ROSETTE-FORFIING CELLS. K . Plandalenaki-Lambrou, A . K a p i k i , C.Vrachnou. T . Thomaids, N. M a t s a n i o t i s . F i r s t Dep a r t m e n t of P e d i a t r i c s of A t h e n s U n i v e r s i t y , A t h e n s , G r e e c e . C e l l u l a r immunity was s t u d i e d by t h e s p o n t a n e o u s r o s e t t e f o r m i n g lymphocyte t e c h n i q u e i n t h e p e r i p h e r a l blood o f f o u r t e e n j a u n d i c e d newborns, who were exchange t r a n s f u s e d . F o l l o w i n g exchange t r a n s f u s i o n a g r a d u a...