340 Preterms <= 32 Weeks have more Fat Tissue at 35 Weeks Corrected Age than Near Terms Born at 35 Weeks

Abstract

Abstracts diet isocaloric to the Lf (n=6) and a Sham group (n=3). At P3 pups from HI-Lf and HI-Iso groups underwent HI injury. At P25, T 2 W images, 1H-MRS and DTI were performed. A Mann-Whitney test was used to compare values between the different groups.Results When compared to HI-Iso group, the number of rats injured (51% vs. 61%), the percentage of injured cortex at P3 (4.9±3.6% vs. 15.0±7.1%, P=0.02) as well as the percentage of cortical loss at P25 (4.6±4.8% vs. 16.7±11.9%, P=0.09) were reduced in the HI-Lf group. At P25, using 1H-MRS, brain metabolites of HI-Lf rats is almost normalized with [Glu+Gln] only remaining decreased whereas the Iso-HI group showed also decreased levels of [Asp] and [totalNAA]. With DTI, white matter FA values tend to be higher in the HI-Lf group than in the HI-Iso group and were comparable to Sham. Conclusion This study shows a potential neuroprotection from maternal nutritional supplementation with Lf after HI in the developing brain of progeny. Background and Aims Arousal from sleep is an important survival mechanism. During sleep-EEG monitoring in healthy term infants we observed that the majority had frequent spontaneous jerky movements (SJM), resembling a Moro reflex, during quiet sleep (QS) followed by periods of marked EEG attenuation. This phenomenon was considered a spontaneous cortical arousal (SpCA). In this study we describe and quantify the observed phenomenon, and investigate factors that influence it. Methods Video-EEG recordings of healthy term infants, aged 1 to 36 hrs, were examined for the presence of SpCAs associated with SJMs. Bursts of EEG activity associated with a SJM (B SJM ) and subsequent lower voltage periods (LV SJM ) of EEG attenuation were identified and labelled on each recording. These were compared to a similar pattern of bursts (B) and lower voltage (LV) periods of "normal" Tracé Alternant (TA) with no SJMs. An arousal index (AI QS ) was calculated as the number of SpCAs per hour of QS. Factors that influenced the AI QS were investigated. Results Eighty-seven video-EEGs were analysed. SJMs occurred during bursts of TA and were followed by significant EEG amplitude attenuation (median amplitude of LV SJM = 7.8 µV versus LV=12.8 µV, p<0.001). SPONTANEOUS CORTICAL AROUSALS IN HEALTHY TERM NEWBORN INFANTS DURING QUIET SLEEPThe median AI QS was 23.9. A significant negative correlation was observed between the AI QS and infant's birth weight (p=0.015). A trend towards a lower AI QS was observed with increasing gestational age (p=0.06). Conclusion SJMs followed by periods of EEG attenuation signify SpCAs in healthy term newborn infants and may represent a normal developmental phenomenon. PRETERMS Background and AimsCerebrospinal fluid (CSF) is known mainly involved in the intracranial homeostatic balance. Disruption of CSF flow may cause distinctive diseases. Therefore, the characterization of normal CSF flow dynamics in children and adults can provide pathophysiological information on diseases affecting CSF circulation. However, available measurem...