387. Synthetic antimalarials. Part XLVII. N 1-3 : 4-dihalogenophenyl-N 5-alkyl- and -N 5 N 5-dialkyl-diguanides

Crowther, A. F.; Curd, F. H. S.; Davey, D. G.; Hendry, J. A.; Hepworth, W.; Rose, F. L.

doi:10.1039/jr9510001774

Cited by 8 publications

(3 citation statements)

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“…EtOAc (25 mL) and the precipitate was collected by filtration, recrystallized (EtOH) and dried under reduced pressure to afford a pink solid; yield: 1.76 g (90%); mp 262-264°C (Lit. 22…”

Section: -Chloro-3-methoxyaniline Hydrochloride (4a)mentioning

confidence: 99%

Convenient Chlorination of Some Special Aromatic Compounds Using N-Chlorosuccinimide

Zhang¹,

Hu²,

Song³

et al. 2012

Synthesis

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Some chlorinated aromatic compounds, including indole, benzofuran, carbazole, pyridine and aniline derivatives, are difficult to obtain through convenient chlorination. We herein report their efficient synthesis through chlorination with N-chlorosuccinimide (NCS). Optimization of the reaction conditions, including the temperature and the choice of solvent, was also investigated. This approach, which is characterized by a facile procedure, comparatively high yields and environmentally friendly features, provides a straightforward and inexpensive route to several chlorinated aromatic compounds.

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“…EtOAc (25 mL) and the precipitate was collected by filtration, recrystallized (EtOH) and dried under reduced pressure to afford a pink solid; yield: 1.76 g (90%); mp 262-264°C (Lit. 22…”

Section: -Chloro-3-methoxyaniline Hydrochloride (4a)mentioning

confidence: 99%

Convenient Chlorination of Some Special Aromatic Compounds Using N-Chlorosuccinimide

Zhang¹,

Hu²,

Song³

et al. 2012

Synthesis

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“…The aryl dibromides 3,5-dibromonitrobenzene (Vogel, 1989), 3,5-dibromoaniline (Crowther et al, 1951), 3,5-dibromophenol (Koelsch, 1939;Barber and Slack, 1947) and 3,5-dibromo-1-chlorobenzene (Vogel, 1989), were prepared according to the literature. The 3,5-dibromo-1-f1uorobenzene, 3,5-dibromotoluene and 1,3,5-tribromobenzene were commercially available.…”

Section: Chemistrymentioning

confidence: 99%

Synthesis of Various 5-(5″-Substituted-3″-Bromophenyl)-2′-β-Deoxyuridines

Persson

Hörnfeldt

Gronowitz

et al. 1996

Antivir Chem Chemother

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SummaryA series of 5-(511-substituted-311-bromophenyl)-2'-~ deoxyuridines were prepared and investigated for their activity against HCMV and HIV. None of the compounds exhibited any activity against HIV at the highest concentration, 100 J.lg rnr". In the HCMV ELISA assay the EO so and COso values of the 5-(5 11-substituted-3 11-bromophenyl)-2'-deoxyuridines were about 60 J.lg rnr" and 150 J.lg rnr", respectively.

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“…To confirm this view the most potent compound of the diguanide series, N'-3:4-dichlorophenyl-N5-isopropyldiguanide (I; R = Cl) (Curd, Davey, Hendry, and Rose, 1950;Crowther, Curd, Davey, Hendry, Hepworth, and Rose, 1951), was selected for study and administered to rabbits. The urine was extracted in the same way as before.…”

Section: Isolation Of An Active Proguanil Metabolitementioning

confidence: 99%