3D axial and circumferential wall shear stress from 4D flow MRI data using a finite element method and a laplacian approach

Sotelo, Julio; Dux-Santoy, Lydia; Guala, Andrea; Rodríguez-Palomares, José F.; Evangelista, Arturo; Sing‐Long, Carlos; Urbina, Jesus; Mura, Joaquín; Hurtado, Daniel E.; Uribe, Sergio

doi:10.1002/mrm.26927

Cited by 44 publications

(45 citation statements)

References 25 publications

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“…However, reproducibility and inter-observer variability of this processing method were previously investigated and show reproducibility and limited inter-observer variability [ 26 ]. Also, the spatial resolution used in this study were similar to other 4D flow MRI studies [ 7 , 27 ].…”

Section: Discussionmentioning

confidence: 60%

Bileaflet mechanical aortic valves do not alter ascending aortic wall shear stress

Farag

Schade

Ooij

et al. 2019

Int J Cardiovasc Imaging

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Progressive ascending aortic dilatation has been observed after mechanical aortic valve replacement (mAVR), possibly due to altered blood flow and wall shear stress (WSS) patterns induced by their bileaflet design. We examined the effect of mAVR on WSS in the ascending aorta using time-resolved 4D flow MRI. Fifteen patients with mechanical aortic valve prostheses, 10 patients with bicuspid aortic valve disease and 10 healthy individuals underwent thoracic 4D flow MRI. Peak systolic hemodynamic parameters (velocity and WSS) and vessel diameters were assessed in the ascending aorta. In addition, three-dimensional per-voxel analysis was used to compare velocity and WSS between patient groups and healthy controls. Peak aortic diameters were significantly higher in mAVR and BAV patients compared to healthy controls (p = 0.011). Mean aortic diameters were comparable between mAVR and BAV patients. No differences in 4D flow MRI-derived mean blood flow velocity and peak WSS were found between the three groups. Compared to healthy controls, mean WSS was significantly lower in mAVR patients (p = 0.031). Per-voxel analysis revealed no increased WSS in the ascending aortic wall and significantly lower velocity and WSS values in mAVR patients compared to healthy controls. In contrast, regions of significantly increased outer lumen velocities and WSS in BAV patients compared to healthy controls were found. This study shows that there is no increased ascending aortic WSS after mAVR. Our results suggest that, in contrast to BAV patients, there is no indication for intensified follow-up of the ascending aorta after mAVR.

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Section: Discussionmentioning

confidence: 60%

Bileaflet mechanical aortic valves do not alter ascending aortic wall shear stress

Farag

Schade

Ooij

et al. 2019

Int J Cardiovasc Imaging

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“…Specifically, [4,6] have shown the effect of WSS on the organization of the endothelial cells. The impact of WSS has been studied on several cardiovascular pathologies, in terms of magnitude [1,7], of axial and circumferential direction [8], and of time variation using the Oscillatory Shear Index (OSI) [9,10].…”

Section: State Of the Artmentioning

confidence: 99%

Towards quantitative evaluation of wall shear stress from 4D flow imaging

Levilly

Castagna

Idier

et al. 2020

Magnetic Resonance Imaging

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Wall shear stress (WSS) is a relevant hemodynamic indicator of the local stress applied on the endothelium surface. More specifically, its spatiotemporal distribution reveals crucial in the evolution of many pathologies such as aneurysm, stenosis, and atherosclerosis. This paper introduces a new solution, called PaLMA, to quantify the WSS from 4D Flow MRI data. It relies on a twostep local parametric model, to accurately describe the vessel wall and the velocity-vector field in the neighborhood of a given point of interest. Extensive validations have been performed on synthetic 4D Flow MRI data, including four datasets generated from patient specific computational fluid dynamics simulations on carotids. The validation tests are focused on the robustness with respect to noise and on the impact of the resolution level in the context of complex flow patterns. The WSS quantification performance reached by PaLMA is significantly higher than the reference one obtained using the smoothing B-spline method proposed by Potters et al. (2015) method, while the computation time is equivalent for both WSS quantification methods.

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“…Therefore, in BAV patients, the elevated WSS of the ascending aorta was related to aortic valve stenosis and aortic dilatation, which was more obviously when patients manifested as AS and nondilated ascending aorta (Farag et al, 2018). If decomposed the WSS vector field into its axial and circumferential components (WSSA and WSSC) from 4D flow MRI data using a Laplacian approach, the average WSSC in the ascending aorta was statistically significant difference as a parameter for evaluating multidirectional flow in complex geometries (Sotelo et al, 2018).…”

Section: Aortic Stenosis: Multiple Imaging Technology Evaluationmentioning

confidence: 99%

Bicuspid Aortic Valve: An Update in Morphology, Genetics, Biomarker, Complications, Imaging Diagnosis and Treatment

Liu

Xie

et al. 2019

Front. Physiol.

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The bicuspid aortic valve, a kind of heart disease that comes from parents, has been paid attention around the world. Although most bicuspid aortic valve (BAV) patients will suffer from some complications including aortic stenosis, aortic regurgitation, endocarditis, and heart dysfunction in the late stage of the disease, there is none symptom in the childhood, which restrains us to diagnose and treatment in the onset phase of BAV. Hemodynamic abnormalities induced by the malformations of the valves in BAV patients for a long time will cause BAV-associated aortopathy: including progress aortic dilation, aneurysm, dissection and rupture, cardiac cyst and even sudden death. At present, preventive surgical intervention is the only effective method used in this situation and the diameter of the aorta is the primary reference criterion for surgery. And the treatment effects are always not satisfactory for patients and clinicians. Therefore, we need more methods to evaluate the progression of BAV and the surgery value and the appropriate intervention time by combining basic research with clinical treatment. In this review, advances in morphology, genetic, biomarkers, diagnosis and treatments are summarized, which expects to provide an update about BAV. It is our supreme expectations to provide some evidences for BAV early screening and diagnosis, and in our opinion, personalized surgical strategy is the trend of future BAV treatment.

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3D axial and circumferential wall shear stress from 4D flow MRI data using a finite element method and a laplacian approach

Cited by 44 publications

References 25 publications

Bileaflet mechanical aortic valves do not alter ascending aortic wall shear stress

Bileaflet mechanical aortic valves do not alter ascending aortic wall shear stress

Towards quantitative evaluation of wall shear stress from 4D flow imaging

Bicuspid Aortic Valve: An Update in Morphology, Genetics, Biomarker, Complications, Imaging Diagnosis and Treatment

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