3D-bioimplants mimicking the structure and function of spine units for the treatment of spinal tuberculosis

Yahia, Sarah; Khalil, Islam A.; Ghoniem, Monira G.; El‐Sherbiny, Ibrahim M.

doi:10.1039/d3ra02351f

Cited by 5 publications

(2 citation statements)

References 40 publications

(93 reference statements)

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“…This achievement is crucial for reducing long-term organ damage and minimizing systemic side effects, a significant step forward in the localized treatment of bone TB. Additionally, the integration of MSNs into gelatine-based hydrogels within three-dimensional vertebral body scaffolds, as investigated by Yahia et al [ 32 , 89 ], represents another innovative approach. These nanoscale drug delivery systems, loaded with antimicrobial agents such as RFP and levofloxacin, provide a localized, sustained release of antibiotics.…”

Section: Nanotechnology In Bone Tuberculosis Treatmentmentioning

confidence: 99%

“…Beyond drug delivery, the role of nanotechnology is multifaceted in tissue engineering, contributing significantly to advancements in various areas, including but not limited to bone tissue engineering, which is particularly relevant for regenerating TB-affected bone. Innovations include bone scaffolds and nanocomposites that support bone growth and recovery [ 29 , 30 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

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Recent Advances in Nanotechnology-Based Strategies for Bone Tuberculosis Management

Luo,

Chen,

Chen

et al. 2024

Pharmaceuticals

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Bone tuberculosis, an extrapulmonary manifestation of tuberculosis, presents unique treatment challenges, including its insidious onset and complex pathology. While advancements in anti-tubercular therapy have been made, the efficacy is often limited by difficulties in achieving targeted drug concentrations and avoiding systemic toxicity. The intricate bone structure and presence of granulomas further impede effective drug delivery. Nano-drug delivery systems have emerged as a promising alternative, offering the enhanced targeting of anti-tubercular drugs. These systems, characterized by their minute size and adaptable surface properties, can be tailored to improve drug solubility, stability, and bioavailability, while also responding to specific stimuli within the bone TB microenvironment for controlled drug release. Nano-drug delivery systems can encapsulate drugs for precise delivery to the infection site. A significant innovation is their integration with prosthetics or biomaterials, which aids in both drug delivery and bone reconstruction, addressing the infection and its osteological consequences. This review provides a comprehensive overview of the pathophysiology of bone tuberculosis and its current treatments, emphasizing their limitations. It then delves into the advancements in nano-drug delivery systems, discussing their design, functionality, and role in bone TB therapy. The review assesses their potential in preclinical research, particularly in targeted drug delivery, treatment efficacy, and a reduction of side effects. Finally, it highlights the transformative promise of nanotechnology in bone TB treatments and suggests future research directions in this evolving field.

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Section: Nanotechnology In Bone Tuberculosis Treatmentmentioning

confidence: 99%