3D Bioprinting in Tissue Engineering for Medical Applications: The Classic and the Hybrid

Xie, Zelong; Gao, Ming; Lobo, Anderson Oliveira; Webster, Thomas J

doi:10.3390/polym12081717

Cited by 109 publications

(81 citation statements)

References 166 publications

(186 reference statements)

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“…The results presented here illustrate for the first time (to the knowledge of the authors) that FFF 3D printing can be used to successfully manufacture PEEK/HA composites up to 30 wt% HA and it addresses a significant gap in the knowledge in this respect. To be suitable for 3D printing, the materials chosen must be firstly printable, they must possess the appropriate structural and mechanical properties for their intended application once they are printed, and they must be biocompatible [ 42 ]. The fact that PEEK/HA composites have been successfully directly 3D printed using FFF, shows that the materials are printable under the 3D printing parameters employed here.…”

Section: Discussionmentioning

confidence: 99%

The Direct 3D Printing of Functional PEEK/Hydroxyapatite Composites via a Fused Filament Fabrication Approach

et al. 2021

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The manufacture of polyetheretherketone/hydroxyapatite (PEEK/HA) composites is seen as a viable approach to help enhance direct bone apposition in orthopaedic implants. A range of methods have been used to produce composites, including Selective Laser Sintering and injection moulding. Such techniques have drawbacks and lack flexibility to manufacture complex, custom-designed implants. 3D printing gets around many of the restraints and provides new opportunities for innovative solutions that are structurally suited to meet the needs of the patient. This work reports the direct 3D printing of extruded PEEK/HA composite filaments via a Fused Filament Fabrication (FFF) approach. In this work samples are 3D printed by a custom modified commercial printer Ultimaker 2+ (UM2+). SEM-EDX and µCT analyses show that HA particles are evenly distributed throughout the bulk and across the surface of the native 3D printed samples, with XRD highlighting up to 50% crystallinity and crystalline domains clearly observed in SEM and HR-TEM analyses. This highlights the favourable temperature conditions during 3D printing. The yield stress and ultimate tensile strength obtained for all the samples are comparable to human femoral cortical bone. The results show how FFF 3D printing of PEEK/HA composites up to 30 wt% HA can be achieved.

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Section: Discussionmentioning

confidence: 99%

The Direct 3D Printing of Functional PEEK/Hydroxyapatite Composites via a Fused Filament Fabrication Approach

et al. 2021

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“…These favorable results promote the use of hybrid bioprinting methods and encourage further research in this area. [48] and [59], published 420 by MDPI, 2020. The production of the bioink is a challenging step in the bioprinting process as it 423 determines the overall functionality of the tissue construct [68].…”

Section: Methods Of Bioprintingmentioning

confidence: 99%

Applications of 3D Bioprinting in Tissue Engineering and Regenerative Medicine

Saini

Segaran

Mayer

et al. 2021

JCM

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Regenerative medicine is an emerging field that centers on the restoration and regeneration of functional components of damaged tissue. Tissue engineering is an application of regenerative medicine and seeks to create functional tissue components and whole organs. Using 3D printing technologies, native tissue mimics can be created utilizing biomaterials and living cells. Recently, regenerative medicine has begun to employ 3D bioprinting methods to create highly specialized tissue models to improve upon conventional tissue engineering methods. Here, we review the use of 3D bioprinting in the advancement of tissue engineering by describing the process of 3D bioprinting and its advantages over other tissue engineering methods. Materials and techniques in bioprinting are also reviewed, in addition to future clinical applications, challenges, and future directions of the field.

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“…The Vascular Endothelial Growth Factor (VEGF) presence in 3D-bioprinted scaffolds that incorporates alginate into one of their matrix mixes promotes vascularization in gelatine microparticles. The hydrogels developed containing hyaluronic acid and semi-interpenetrating systems with a dextran basis [171]. The use of neural stem cells to produce artificial neural tissue was organically printed with collagen and VEGF-releasing fibrin gel.…”

Section: Tissue Engineering (Te)mentioning

confidence: 99%

Additive Manufacturing of Biopolymers for Tissue Engineering and Regenerative Medicine: An Overview, Potential Applications, Advancements, and Trends

Veeman

Sai

Sureshkumar³

et al. 2021

International Journal of Polymer Science

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As a technique of producing fabric engineering scaffolds, three-dimensional (3D) printing has tremendous possibilities. 3D printing applications are restricted to a wide range of biomaterials in the field of regenerative medicine and tissue engineering. Due to their biocompatibility, bioactiveness, and biodegradability, biopolymers such as collagen, alginate, silk fibroin, chitosan, alginate, cellulose, and starch are used in a variety of fields, including the food, biomedical, regeneration, agriculture, packaging, and pharmaceutical industries. The benefits of producing 3D-printed scaffolds are many, including the capacity to produce complicated geometries, porosity, and multicell coculture and to take growth factors into account. In particular, the additional production of biopolymers offers new options to produce 3D structures and materials with specialised patterns and properties. In the realm of tissue engineering and regenerative medicine (TERM), important progress has been accomplished; now, several state-of-the-art techniques are used to produce porous scaffolds for organ or tissue regeneration to be suited for tissue technology. Natural biopolymeric materials are often better suited for designing and manufacturing healing equipment than temporary implants and tissue regeneration materials owing to its appropriate properties and biocompatibility. The review focuses on the additive manufacturing of biopolymers with significant changes, advancements, trends, and developments in regenerative medicine and tissue engineering with potential applications.

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3D Bioprinting in Tissue Engineering for Medical Applications: The Classic and the Hybrid

Cited by 109 publications

References 166 publications

The Direct 3D Printing of Functional PEEK/Hydroxyapatite Composites via a Fused Filament Fabrication Approach

The Direct 3D Printing of Functional PEEK/Hydroxyapatite Composites via a Fused Filament Fabrication Approach

Applications of 3D Bioprinting in Tissue Engineering and Regenerative Medicine

Additive Manufacturing of Biopolymers for Tissue Engineering and Regenerative Medicine: An Overview, Potential Applications, Advancements, and Trends

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