3D chromatin architecture and epigenetic regulation in cancer stem cells

Feng, Yuliang; Pauklin, Siim

doi:10.1007/s13238-020-00819-2

Cited by 30 publications

(25 citation statements)

References 131 publications

(145 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3). Indeed, the proposition of mutation-less cancer evolution and purely epigenetic programming of hallmark cancer phenotypes was raised almost a decade ago (49) and is increasingly discussed (46,(50)(51)(52).…”

Section: Nonmutational Epigenetic Reprogrammingmentioning

confidence: 99%

Hallmarks of Cancer: New Dimensions

Hanahan¹

2022

Cancer Discovery

5,088

2,906

View full text Add to dashboard Cite

The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity of cancer phenotypes and genotypes into a provisional set of underlying principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and disrupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogramming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added to the roster of functionally important cell types in the tumor microenvironment.Significance: Cancer is daunting in the breadth and scope of its diversity, spanning genetics, cell and tissue biology, pathology, and response to therapy. Ever more powerful experimental and computational tools and technologies are providing an avalanche of "big data" about the myriad manifestations of the diseases that cancer encompasses. The integrative concept embodied in the hallmarks of cancer is helping to distill this complexity into an increasingly logical science, and the provisional new dimensions presented in this perspective may add value to that endeavor, to more fully understand mechanisms of cancer development and malignant progression, and apply that knowledge to cancer medicine.

show abstract

Section: Nonmutational Epigenetic Reprogrammingmentioning

confidence: 99%

Hallmarks of Cancer: New Dimensions

Hanahan¹

2022

Cancer Discovery

5,088

2,906

View full text Add to dashboard Cite

show abstract

“…E–P interaction is also an important mechanism in cancer development (see review by Feng et al [ 103 , 104 ]). ALL is mainly caused by mixed-lineage leukaemia ( MLL ) gene rearrangements, and H3 lysine 79 di- or tri-methylation (H3K79me2/3) is required for transcription factor binding at enhancers in MLL-AF4 leukaemia cells [ 105 ].…”

Section: Types Of 3d Chromatin Architecturementioning

confidence: 99%

3D chromatin architecture and transcription regulation in cancer

2022

Self Cite

View full text Add to dashboard Cite

Chromatin has distinct three-dimensional (3D) architectures important in key biological processes, such as cell cycle, replication, differentiation, and transcription regulation. In turn, aberrant 3D structures play a vital role in developing abnormalities and diseases such as cancer. This review discusses key 3D chromatin structures (topologically associating domain, lamina-associated domain, and enhancer–promoter interactions) and corresponding structural protein elements mediating 3D chromatin interactions [CCCTC-binding factor, polycomb group protein, cohesin, and Brother of the Regulator of Imprinted Sites (BORIS) protein] with a highlight of their associations with cancer. We also summarise the recent development of technologies and bioinformatics approaches to study the 3D chromatin interactions in gene expression regulation, including crosslinking and proximity ligation methods in the bulk cell population (ChIA-PET and HiChIP) or single-molecule resolution (ChIA-drop), and methods other than proximity ligation, such as GAM, SPRITE, and super-resolution microscopy techniques.

show abstract

“…However, many functional changes brought by histone modifications remained largely uncharacterized but research points to a complex regulatory network affected by the spatial structural features and external stress ( 20 ). For example, omics approaches reveals that the alteration in the three-dimensional (3D) chromatin architecture caused by histone modification is a crucial epigenetic element important in development, cancer, and aging ( 21 ).…”

Section: Epigenetic Mechanisms In Vascular Agingmentioning

confidence: 99%

Targeting Epigenetic Mechanisms in Vascular Aging

Lin

Ding

et al. 2022

Front. Cardiovasc. Med.

Self Cite

View full text Add to dashboard Cite

Environment, diseases, lack of exercise, and aged tendency of population have becoming crucial factors that induce vascular aging. Vascular aging is unmodifiable risk factor for diseases like diabetes, hypertension, atherosclerosis, and hyperlipidemia. Effective interventions to combat this vascular function decline is becoming increasingly urgent as the rising hospitalization rate caused by vascular aging-related diseases. Fortunately, recent transformative omics approaches have enabled us to examine vascular aging mechanisms at unprecedented levels and precision, which make our understanding of slowing down or reversing vascular aging become possible. Epigenetic viz. DNA methylation, histone modifications, and non-coding RNA-based mechanisms, is a hallmark of vascular aging, its deregulation leads to aberrant transcription changes in tissues. Epigenetics mechanisms by mediating covalent modifications to DNA and histone proteins, consequently, influence the sensitivity and activities of signaling pathways in cells and tissues. A growing body of evidence supports correlations between epigenetic changes and vascular aging. In this article, we will provide a comprehensive overview of epigenetic changes associated with vascular aging based on the recent findings with a focus on molecular mechanisms of action, strategies to reverse epigenetic changes, and future perspectives.

show abstract

3D chromatin architecture and epigenetic regulation in cancer stem cells

Cited by 30 publications

References 131 publications

Hallmarks of Cancer: New Dimensions

Hallmarks of Cancer: New Dimensions

3D chromatin architecture and transcription regulation in cancer

Targeting Epigenetic Mechanisms in Vascular Aging

Contact Info

Product

Resources

About