3D composites based on the blends of chitosan and collagen with the addition of hyaluronic acid

Sionkowska, Alina; Kaczmarek, Beata; Lewandowska, Katarzyna; Grabska-Zielińska, Sylwia; Pokrywczyńska, Marta; Kloskowski, Tomasz

doi:10.1016/j.ijbiomac.2016.04.085

Cited by 83 publications

(45 citation statements)

References 35 publications

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“…This indicates that there are some specific interactions between hydrogels and cross-linking molecules, which need to be fully evaluated in further research. Our observations are in line with other research on binary and ternary blends (chitosan, collagen and hyaluronic acid) cross-linked by DAS [59,62]. It was also observed that the addition of collagen to silk fibroin increased the swelling ability of the material; the same as with the addition of chitosan to silk fibroin [42].…”

Section: Samplesupporting

confidence: 92%

“…The addition of dialdehyde starch improves the organization of sponges as has been shown by Kaczmarek et al [57] for when the sponges were made of gelatin and chitosan with 5% addition of DAS. However, significant changes were not observed for scaffolds based on binary and ternary mixtures, likewise, in our earlier research, when chitosan and collagen were mixed with sodium alginate [58] and when collagen, chitosan and hyaluronic acid were mixed together to form ternary blend [59,60].…”

Section: Microstructure Of the Scaffoldssupporting

confidence: 48%

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Physico-Chemical Characterization and Biological Tests of Collagen/Silk Fibroin/Chitosan Scaffolds Cross-Linked by Dialdehyde Starch

et al. 2020

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In this study, three-dimensional (3D) biopolymeric scaffolds made from collagen, silk fibroin and chitosan were successfully prepared by the freeze drying method. Dialdehyde starch (DAS) was used as a cross-linking agent for the materials. The properties of the materials were studied using density and porosity measurements, scanning electron microscope (SEM) imaging, swelling and moisture content measurements. Additionally, cytocompatibility of the materials in contact with MG-63 osteoblast-like cells was tested by live/dead staining and resazurin reduction assay on days 1, 3 and 7. It was found that new 3D materials made from collagen/silk fibroin/chitosan binary or ternary mixtures are hydrophilic with a high swelling ability (swelling rate in the range of 1680–1900%). Cross-linking of such biopolymeric materials with DAS increased swelling rate up to about 2100%, reduced porosity from 96–97% to 91–93%, and also decreased density and moisture content of the materials. Interestingly, presence of DAS did not influence the microstructure of the scaffolds as compared to non-cross-linked samples as shown by SEM. All the tested samples were found to be cytocompatible and supported adhesion and growth of MG-63 cells as shown by live–dead staining and metabolic activity test.

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Section: Samplesupporting

confidence: 92%

Section: Microstructure Of the Scaffoldssupporting

confidence: 48%

Physico-Chemical Characterization and Biological Tests of Collagen/Silk Fibroin/Chitosan Scaffolds Cross-Linked by Dialdehyde Starch

et al. 2020

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“…[83] The studies demonstrated the synergistic effect of chitosan/collagen/ hyaluronic acid mixture on human osteogenesis due to the enhanced calcium deposition and osteoblasts differentiation when compared to pure polymers. [84] Such materials may provide an appropriate environment to obtain cartilage-like tissues due to the enhanced chondrocytes proliferation and differentiation. [84] Such materials may provide an appropriate environment to obtain cartilage-like tissues due to the enhanced chondrocytes proliferation and differentiation.…”

Section: F I G U R E 3 the Hydrogen Bonds Between Chitosan And Main Amentioning

confidence: 99%

“…The TA addition improves the moisture of a material. [84,90,92,161] [165] The TA use as an additive to a chitosan and collagen mixture (Figure 9) modifies the properties of the material.…”

Section: Tannic Acidmentioning

confidence: 99%

Chitosan/collagen blends with inorganic and organic additive—A review

Kaczmarek

Sionkowska

2017

Adv Polym Technol

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This review provides a report on recent studies of composite materials based on a chitosan and collagen mixture due to their biocompatibility and bioactivity. Those natural polymers are most widely used to obtain biomaterials. However, the materials based on chitosan/collagen complexes present poor mechanical parameters, as well as high swelling behavior and enzymatic degradation rate. Such properties are considered problematic for the material clinical application. An increased interest in composite materials has been observed due to their enhanced physicochemical properties. A composite material preparation involves different compounds addition to natural polymers. Herein, the use of organic and inorganic additives has been reported. Moreover, the potential application of composite materials based on chitosan/ collagen complexes in the tissue engineering science has been discussed. K E Y W O R D Schitosan, collagen, composite materials, tissue engineering How to cite this article: Kaczmarek B, Sionkowska A. Chitosan/collagen blends with inorganic and organic additive-A review. Adv Polym Technol.

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“…Chitosan, as a natural polymer, has been widely used in tissue engineering due to its favourable biological properties such as biodegradability, biocompatibility and nontoxicity [7,8]. The hydrogel form, especially the thermo-sensitive hydrogel, can serve as drug or growth factor delivery system and as injectable material for irregular-shaped tissue repair [9].…”

Section: Introductionmentioning

confidence: 99%