3D conformal HDR brachytherapy and external beam irradiation combined with temporary androgen deprivation in the treatment of localized prostate cancer

Favorable clinical outcomes of three-dimensional computer-optimized high-dose-rate prostate brachytherapy in the management of localized prostate cancer

“…High-dose-rate (HDR) prostate brachytherapy in combination with external beam radiotherapy has been reported in several series with mature followup as a safe and highly effective therapy for localized adenocarcinoma of the prostate (1)(2)(3)(4)(5)(6). The outcomes of HDR brachytherapy are particularly impressive compared to outcomes of external beam radiation alone for patients with tumors with higher risk features (7).…”

Evaluation of clinical benefits achievable by using different optimization algorithms during real-time prostate brachytherapy

“…In this case, the technique involving higher doses applied in some areas in the prostate by increasing the high-dose volume around one or more needles is called the 'boost-in-boost strategy', as it is unaffected by organ motion, PTV volume changes and setup errors [5,17,20].…”

“…In every case the prescribed dose was 10 Gy. The whole planning procedure, including needle implantation and preparation of treatment plan, was based on transrectal ultrasound (TRUS) images [8,12,16,17]. A microSelectron HDR (Nucletron B.V., Veenendaal, the Netherlands) device with iridium-192 source was used to deliver the dose [1,3,4,18].…”

“…If there is any risk of involvement, the medial part of the seminal vesicles can be included in the CTV [20]. In our clinical practice with the real-time intraoperative planning, no margin is applied and thus the planning target volume (PTV) is considered to be CTV [7,17,20,21], resulting in smaller PTV volumes than for external beam radiotherapy [22].…”

Miniature LiF: Mg, Cu, P TLDs to study the effect of applicator material in 192-Ir brachytherapy

“…[1][2][3] Inhomogeneity corrections are typically ignored in brachytherapy dose calculations. [4][5][6] This applies to the patient as well as the applicator material.…”