3D double inversion recovery MR imaging: Clinical applications and usefulness in a wide spectrum of central nervous system diseases

Umino, Maki; Maeda, Masayuki; Yuichiro,; Tomimoto, Hidekazu; Sakuma, Hajime

doi:10.1016/j.neurad.2018.06.002

Cited by 15 publications

(21 citation statements)

References 73 publications

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“…With respect to infratentorial region, DIR identified increased number of lesions in cerebellum and brain stem with better delineation, even compared with the T2W_TSE which still considered as a gold sequence at this region. These findings were also in agreement with the findings reported by Abidi et al [18], Umino et al [17], Prosperini et al [32], and Hickman et al [33].…”

Section: Discussionsupporting

confidence: 93%

“…The result of our study was quite promising, DIR showed significantly higher total MS lesions load (N = 3647) in all anatomical regions compared to FLAIR imaging (N = 2896) and T2W_TSE (N = 2697), our overall findings were in agreement with the findings reported in different studies of Abidi et al [18], Umino et al [17], Prosperini et al [32], and Hickman et al [33]. With respect to infratentorial region, DIR identified increased number of lesions in cerebellum and brain stem with better delineation, even compared with the T2W_TSE which still considered as a gold sequence at this region.…”

Section: Discussionsupporting

confidence: 92%

“…A noticeably higher number of lesions seen in juxtacortical white matter, these findings were in agreement with those reported from Abidi et al [18] and Hickman et al [33] but, Umino et al [17] reported a slightly lower number of detected lesions in this region, they noted slightly more lesions in the juxtacortical with FLAIR imaging. And also, Prosperini et al [32] noted statistically significant increase in juxtacortical and mixed WM/GM lesions detection on DIR imaging compared to FLAIR and T2W_TSE.…”

Section: Discussionsupporting

confidence: 91%

“…Abidi et al [18], Umino et al [17], Prosperini et al [32], and Hickman et al [33], differed in their findings from our study as they reported a lower number of MS lesions in deep white matter with the DIR and slightly higher number of lesions at this region by FLAIR imaging sequence.…”

Section: Discussioncontrasting

confidence: 83%

“…Recently, the increasing number of gray matter involvement has been proved by pathophysiological reviews in MS patients [15,16]. An obvious histopathological variation, particularly in patients with primary progressive or secondary progressive MS is cortical demyelination, so it is required to demonstrate cortical and subcortical lesions by different pulse sequences [5,17].…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Lesion load assessment among multiple sclerosis patient using DIR, FLAIR, and T2WI sequences

Almutairi

Hassan

Suppiah

et al. 2020

Egypt J Radiol Nucl Med

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Background Magnetic resonance imaging (MRI) is one of the diagnostic imaging modalities employing in lesion detection in neurological disorders such as multiple sclerosis (MS). Advances in MRI techniques such as double inversion recovery (DIR) made it more sensitive to distinguish lesions in the brain. To investigate the lesion load on different anatomical regions of the brain with MS using DIR, fluid attenuated inversion recovery (FLAIR) and T2-weighted imaging (T2WI) sequences. A total of 97 MS patients were included in our retrospective study, confirmed by neurologist. The patients were randomly selected from the major hospital in Saudi Arabia. All images were obtained using 3T Scanner (Siemens Skyra). The images from the DIR, FLAIR, and T2WI sequence were compared on axial planes with identical anatomic position and the number of lesions was assigned to their anatomical region. Results Comparing the lesion load measurement at various brain anatomical regions showed a significant difference among those three methods (p < 0.05). Conclusion DIR is a valuable MRI sequence for better delineation, greater contrast measurements and the increasing total number of MS lesions in MRI, compared with FLAIR, and T2WI and DIR revealed more intracortical lesions as well; therefore, in MS patients, it is recommended to add DIR sequence in daily routine imaging sequences.

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