3D full-field biomechanical testing of a glenoid before and after implant placement

Zhou, Yuxiao; Gong, Chujie; Lewis, Gregory S.; Armstrong, April D.; Du, Jinglei

doi:10.1016/j.eml.2019.100614

Cited by 14 publications

(7 citation statements)

References 33 publications

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“…The measurement of trabecular strains is particularly important for orthopedic applications as it can be used to predict bone remodeling and assess localized fracture risk 28 . Within this study, strains were measured using DVC at varying measurement resolutions (152–608 µm), which represents tissue‐ to apparent‐level strains with the latter more relevant to previous DVC studies involving the shoulder 15,16,18 . Our results indicate that strain measurement resolution had a statistically significant impact ( p < 0.001) on the 95th percentile of the third principal strain measured within the trabecular bone.…”

Section: Discussionmentioning

confidence: 82%

“…As such, the advantages of DVC have been utilized to undercover the local load carrying characteristics of bone. At the whole bone level, DVC has previously been applied as a preclinical assessment tool to evaluate peri‐implant bone strains of cadaveric shoulder specimens treated with TSA components 15,16 . However, as DVC is an emerging experimental technique, it is difficult to comprehend and assess the risk of failure associated with corresponding full‐field strain measurements within bone specifically for shoulder orthopedic applications.…”

Section: Introductionmentioning

confidence: 99%

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Full‐field experimental analysis of the influence of microstructural parameters on the mechanical properties of humeral head trabecular bone

Kusins

Knowles

Martensson

et al. 2021

Journal Orthopaedic Research

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Understanding the mechanical properties of trabecular bone within the metaphysis of the proximal humerus is becoming increasingly important for the design of humeral head joint replacement components that prioritize bone preservation. The aim of this study was to perform full‐field mechanical testing methods on isolated trabecular bone cores from the humeral head to experimentally measure the local magnitude of strain before macroscopic failure and to characterize the ultimate strength of each core. Isolated cubic trabecular bone cores were extracted from the center of humeral head osteotomies retrieved from (1) patients with end‐stage osteoarthritis (OA) undergoing total shoulder arthroplasty (TSA) and (2) normal nonpathologic cadaveric humeral heads. A custom computed tomography (CT)‐compatible loading device was used to perform compressive mechanical testing. For 10 of the OA specimens, stepwise loading was performed directly within a microCT scanner and digital volume correlation (DVC) was used to measure full‐field strains throughout the trabecular structure. A higher variability in ultimate strength was measured for the trabecular cores retrieved from OA humeral heads (range: 2.8–7.6 MPa) compared to the normal cadaveric humeral heads (range: 2.2–5.4 MPa), but no statistically significant difference between the groups was found (p = 0.06). Ultimate strength was strongly correlated with bone volume fraction (OA r2 = 0.72; normal r2 = 0.76) and bone mineral content (OA r2 = 0.79; normal r2 = 0.77). At the trabecular level, 95th percentile of third principal strains, measured at a subvolume size of 152 µm, exceeded 19,000 µε for each of the 10 specimens (range: −19,551 to −36,535 µε) before macroscopic failure of the cores occured. No strong linear correlations (r2 ≥ 0.50) were found between the median or 95th percentile of DVC third principal strain and the corresponding morphometric parameters of each individual bone core. The results of this study indicate that bone volume fraction and bone mineral content heavily influence the apparent ultimate strength of trabecular bone cores collected from OA patients undergoing TSA. Clinical significance: The strong correlations observed within this study further emphasize the importance of considering bone mineral content or bone volume fraction measurements in assessing the localized risk of trabecular bone fracture for orthopedic applications.

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Section: Discussionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Full‐field experimental analysis of the influence of microstructural parameters on the mechanical properties of humeral head trabecular bone

Kusins

Knowles

Martensson

et al. 2021

Journal Orthopaedic Research

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“…Moreover, the fibers' fusion points remained mostly unstrained until failure, suggesting the strong adhesion between the fibers [166] (Figure 5). An interesting study compares the mechanical behavior of a native glenoid with the mechanical behavior of an implant glenoid mimicking the physiological loading conditions using a loading equipment coupled with micro-CT [169]. However, besides scaffolds used in regenerative medicine, other materials with vast application fields were characterized in this way-rocks [170], cement-based materials [63], composites for wind turbine blades [171], metamaterials [172], and advanced ceramics [173]-even industrial micro-CT was employed for the evaluation of mechanically tested samples [174].…”

Section: Evaluation Of Architectural Features Under Mechanical Loadmentioning

confidence: 99%

Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications

et al. 2021

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The ever-growing field of materials with applications in the biomedical field holds great promise regarding the design and fabrication of devices with specific characteristics, especially scaffolds with personalized geometry and architecture. The continuous technological development pushes the limits of innovation in obtaining adequate scaffolds and establishing their characteristics and performance. To this end, computed tomography (CT) proved to be a reliable, nondestructive, high-performance machine, enabling visualization and structure analysis at submicronic resolutions. CT allows both qualitative and quantitative data of the 3D model, offering an overall image of its specific architectural features and reliable numerical data for rigorous analyses. The precise engineering of scaffolds consists in the fabrication of objects with well-defined morphometric parameters (e.g., shape, porosity, wall thickness) and in their performance validation through thorough control over their behavior (in situ visualization, degradation, new tissue formation, wear, etc.). This review is focused on the use of CT in biomaterial science with the aim of qualitatively and quantitatively assessing the scaffolds’ features and monitoring their behavior following in vivo or in vitro experiments. Furthermore, the paper presents the benefits and limitations regarding the employment of this technique when engineering materials with applications in the biomedical field.

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“…Mechanical testing coupled with micro-CT and digital volume correlation have been applied to map strain in trabecular bone blocks (Bay et al, 1999;Gillard et al, 2014;Jiroušek et al, 2011;Liu and Morgan, 2007), cortical bone (Christen et al, 2012;Dall'Ara et al, 2014), whole bones (Hussein et al, 2012;Kusins et al, 2019;Tozzi et al, 2016), bone-cement interfaces (Tozzi et al, 2012;Zhu et al, 2016). This method has been extended to map strain in boneimplant constructs first in our prior work and later also in other studies (Du et al, 2015;Le Cann et al, 2017;Zhou et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

3D full-field strain in bone-implant and bone-tooth constructs and their morphological influential factors

Zhou

Gong

Hossaini-Zadeh

et al. 2020

Journal of the Mechanical Behavior of Biomedical Materials

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The biomechanics of bone-tooth and bone-implant interfaces affects the outcomes of several dental treatments, such as implant placement, because bone, tooth and periodontal ligament are living tissues that adapt to the changes in mechanical stimulations. In this work, mechanical testing coupled with micro-CT was performed on human cadaveric mandibular bone-tooth and bone-implant constructs. Using digital volume correlation, the 3D full-field strain in bone under implant loading and tooth loading was measured. Concurrently, bone morphology and boneimplant and bone-tooth contact were also measured through analysis of micro-CT images. The results show that strain in bone increased when a tooth was replaced by a dental implant. Strain concentration was observed in peri-implant bone, as well as in the buccal bone plate, which is also the clinically-observed bone resorption area after implant placement. Decreasing implant stability measurements (resonance frequency analysis and torque test) indicated increased peri-implant strain, but their relationships may not be linear. Peri-implant bone strain linearly increased with decreasing bone-implant contact (BIC) ratio. It also linearly decreased with increasing bone-tooth/ bone-implant contact ratio. The high strain in the buccal bone plate linearly increased with decreasing buccal bone plate thickness. The results of study revealed 3D full-field strain in bonetooth and bone-implant constructs, as well as their several morphological influential factors.

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3D full-field biomechanical testing of a glenoid before and after implant placement

Cited by 14 publications

References 33 publications

Full‐field experimental analysis of the influence of microstructural parameters on the mechanical properties of humeral head trabecular bone

Full‐field experimental analysis of the influence of microstructural parameters on the mechanical properties of humeral head trabecular bone

Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications

3D full-field strain in bone-implant and bone-tooth constructs and their morphological influential factors

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