3D Graphene hydrogel – gold nanoparticles nanocomposite modified glassy carbon electrode for the simultaneous determination of ascorbic acid, dopamine and uric acid

Zhu, Qing; Bao, Jing; Huo, Danqun; Yang, Mei; Hou, Changjun; Guo, Jianfeng; Chen, Mei; Fa, Huanbao; Luo, Xiaogang; Ma, Yi

doi:10.1016/j.snb.2016.09.116

Cited by 110 publications

(38 citation statements)

References 44 publications

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“…In recent years, they have gained great attention because of their high specific surface area, good electron mobility, porous, and 3D-networked structure [27][28][29]. Graphene hydrogel (GH) is a 3D graphene material that can be prepared easily by hydrothermal reduction [30][31][32] and chemical reduction [33,34]. To date, GH has been used in supercapacitors [30,34,35] and electrochemical sensors [36][37][38][39].…”

Section: Introductionmentioning

confidence: 99%

“…To date, GH has been used in supercapacitors [30,34,35] and electrochemical sensors [36][37][38][39]. GH-based nanocomposites show excellent electrocatalytic activity to the oxidation of ascorbic acid (AA), dopamine (DA), and uric acid (UA), which has been used in their simultaneous detection in human serum samples [31,32]. In our previous work, we prepared gold nanoparticle-doped GH using hydrothermal method at temperatures higher than 100 • C, and its properties were investigated with various characterization methods.…”

Section: Introductionmentioning

confidence: 99%

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Electro-Oxidation and Simultaneous Determination of Indole-3-Acetic Acid and Salicylic Acid on Graphene Hydrogel Modified Electrode

Cao

Zhu

et al. 2019

Sensors

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A selective and sensitive electrochemical sensor was developed for simultaneous detection of phytohormones indole-3-acetic acid (IAA) and salicylic acid (SA). The sensing interface was fabricated on a porous, three-dimensional networked graphene hydrogel (GH) modified glassy carbon electrode (GCE). The electrocatalytic behavior of IAA and SA on the surface of the modified electrode (GH/GCE) was investigated by cyclic voltammetry and linear sweep voltammetry. Results show that the oxidation reactions of IAA and SA occur at different potentials, which enable their simultaneous detection at the sensing interface. Under optimal conditions, the GH/GCE exhibited good selectivity and stability and its response, unaffected by various interferents, was linear in the range of 4 to 200 µM of IAA and SA. The limit of detection (S/N = 3) achieved were 1.42 µM for IAA and 2.80 µM for SA. The sensor performance was validated by measuring for IAA and SA in real vegetable samples with satisfactory results.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electro-Oxidation and Simultaneous Determination of Indole-3-Acetic Acid and Salicylic Acid on Graphene Hydrogel Modified Electrode

Cao

Zhu

et al. 2019

Sensors

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“…The electrochemical profile of DA ( Figure 5) inside of both platforms presents a typical quasi-reversible oxidation-reduction similar to the DA in solution at ca. 0.2 V [48]. In addition, the electrochemical response of AA (inside of both platforms) shows the anodic peak, even though the cathodic peak is not present.…”

Section: Discussionmentioning

confidence: 93%

“…Considering that DA is a relevant molecule that regulates functions of the central nervous system, its detection is of great interest. However, it is known that not only DA but also AA is present in the extracellular fluid of the central nervous system, and in higher concentration [48]. Moreover, the electrochemical determination of DA becomes difficult because the AA oxidation potential is close to DA oxidation potential when solid unmodified electrodes are used [49].…”

Section: Discussionmentioning

confidence: 99%

Hydrogel-Graphene Oxide Nanocomposites as Electrochemical Platform to Simultaneously Determine Dopamine in Presence of Ascorbic Acid Using an Unmodified Glassy Carbon Electrode

et al. 2018

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The detection of dopamine, an important neurotransmitter in the central nervous system, is relevant because low levels of dopamine can cause brain disorders. Here, a novel electrochemical platform made of a hydrogel–graphene oxide nanocomposite was employed to electrochemically determine simultaneously dopamine (DA) and ascorbic acid (AA). Unlike previous work, where the base electrode is modified, the active material (graphene oxide, GO) was dispersed in the hydrogel matrix, making an active nanocomposite where the electrochemical detection occurs. The GO, hydrogel and nanocomposite synthesis is described. Dynamic Light Scattering, UV-visible and FTIR spectroscopies showed that the synthesized GO nanoparticles present 480 nm of diagonal size and a few sheets in height. Moreover, the polymer swelling, the adsorption capacity and the release kinetic of DA and AA were evaluated. The nanocomposite showed lower swelling capacity, higher DA partition coefficient and faster DA release rate than in the hydrogel. The electrochemical measurement proved that both materials can be employed to determine DA and AA. Additionally, the nanocomposite platform allowed the simultaneous determination of both molecules showing two well separated anodic peaks. This result demonstrates the importance of the incorporation of the nanomaterial inside of the hydrogel and proves that the nanocomposite can be used as a platform in an electrochemical device to determinate DA using an unmodified glassy carbon electrode.

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“…The 3DGH and Au NPs have a synergistic effect on the electroactivity of each other for sensitive and selective determination of AA, DA and UA. Very low limit of detection in nM range was achieved for targeted analytes .…”

Section: Comparison Of the Modified Electrodes For Simultaneous Sensimentioning

confidence: 99%

Modified Electrodes for Selective Voltammetric Detection of Biomolecules

2018

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Electrochemical sensors for selective analysis of biomolecules got tremendous attention due to their better sensitivity and construction possibility of the portable cost‐effective devices. The individual or simultaneous sensing of ascorbic acid (AA), dopamine (DA), and uric acid (UA) is challenging due to their close electrooxidation and co‐existing. Recent years, substantial progress is made to develop electrode with smart materials to overcome the issue related to simultaneous sensing. This review is comparatively consolidating the work was done in fabrication of electrochemical sensors for the simultaneous sensing of AA, DA and UA. The various modification materials such as graphene, CNTs, conductive polymers and the ionic liquids characteristics are concisely described with their figure of merits. In the end, the critical analysis, future prospects, and challenges in commercialization are described.

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3D Graphene hydrogel – gold nanoparticles nanocomposite modified glassy carbon electrode for the simultaneous determination of ascorbic acid, dopamine and uric acid

Cited by 110 publications

References 44 publications

Electro-Oxidation and Simultaneous Determination of Indole-3-Acetic Acid and Salicylic Acid on Graphene Hydrogel Modified Electrode

Electro-Oxidation and Simultaneous Determination of Indole-3-Acetic Acid and Salicylic Acid on Graphene Hydrogel Modified Electrode

Hydrogel-Graphene Oxide Nanocomposites as Electrochemical Platform to Simultaneously Determine Dopamine in Presence of Ascorbic Acid Using an Unmodified Glassy Carbon Electrode

Modified Electrodes for Selective Voltammetric Detection of Biomolecules

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