3D multi-channel bi-functionalized silk electrospun conduits for peripheral nerve regeneration

Electrospun silk fibroin mat enhances tendon-bone healing in a rabbit extra-articular model

“…Han et al (2015) demonstrated that wrapping made from hydroxyapatite-doped polycaprolactone electrospun mats could enhance tendon-bone healing of autografts in a rabbit ACL reconstruction model. Electrospun structures of SF have been used in the regeneration of skin, vessels and peripheral nerves (Marelli et al 2010;Jeong et al 2014;Dinis et al 2015;Sheikh et al 2015) but their effects on tendon-bone healing remain unclear.…”

“…The metabolites of PLLA and PGA are acidic, which is harmful to organism, but SF has no such a drawback. Electrospun SF scaffolds have been studied extensively in the regeneration of numerous tissues, such as skin, vessel and peripheral nerve, showing encouraging prospects (Marelli et al 2010;Jeong et al 2014;Dinis et al 2015;Sheikh et al 2015), but their effects on tendon-bone healing have not been investigated.…”

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

“…Engineered bionic conduit showed promising in vivo results [132]. Research has also reported the development of silk fibroin conduits loaded with nerve growth factors [133][134][135][136][137][138]. Despite the promising results, no silk conduit has yet been FDA approved.…”

Lysine-doped polypyrrole/spider silk protein/poly( l -lactic) acid containing nerve growth factor composite fibers for neural application

“…In addition, adequate PLLA was added into the RSSP electrospinning liquid to improve the spinnability and regulate the degradation rate. The presence of nerve growth factor (NGF) has been demonstrated to enhance neuronal outgrowth [21] and was used as a chemo-attractant to stimulate axon guidance. Meanwhile, lysine was used as the dopant.…”