3D Multiecho Dixon for the Evaluation of Hepatic Iron and Fat in a Clinical Setting

Henninger, Benjamin; Zoller, Heinz; Kannengießer, Stephan; Zhong, Xiaodong; Jaschke, Werner; Kremser, Christian

doi:10.1002/jmri.25630

Cited by 46 publications

(46 citation statements)

References 41 publications

(89 reference statements)

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“…To overcome this artefact by dealing with B0 field inhomogeneity, multipoint Dixon techniques have been developed . However, fat‐water swaps still remain a problem in 3D multiple gradient echo Dixon‐based MRI . For further clinical application and exact measurement of intramuscular fat quantification by Dixon‐based MRI, technical advances are warranted to overcome this issue.…”

Section: Discussionmentioning

confidence: 99%

Muscle fat quantification using magnetic resonance imaging: case–control study of Charcot–Marie–Tooth disease patients and volunteers

Kim

Yoon

Choi

et al. 2019

J cachexia sarcopenia muscle

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Background This study aimed to evaluate the potential value of 3D multiple gradient echo Dixon‐based magnetic resonance imaging (MRI) sequence as a tool for thigh intramuscular fat quantification in Charcot–Marie–Tooth disease (CMT) patients. Methods A prospective comparison study comprising 18 CMT patients and 18 age/sex‐matched volunteers was performed. MRI including 3D multiple gradient echo Dixon‐based imaging was performed for each subject. Region of interest analyses were performed at the upper and lower third of both thighs. The two‐sample t ‐test or Wilcoxon rank sum test was used for intergroup comparison of the mean muscle fat fraction. Intraclass correlation coefficients were used to evaluate the interobserver agreement and test–retest reproducibility. Semiquantitive analysis using the Goutallier classification (Grades 0–4) was performed on T1‐weighted images in upper thigh muscles. For Goutallier Grade 0 muscles, comparison of the mean intramuscular fat fraction between volunteers and CMT patients was performed. Results The interobserver agreements were excellent for all measurements (intraclass correlation coefficients > 0.8). Mean muscle fat fractions were significantly higher in all the measured muscles of CMT patients ( P < 0.05) except in the adductor magnus in the upper thigh ( P = 0.109). Goutallier Grade 0 muscles of the CMT patients showed a significantly higher mean fat fraction compared with that of the volunteers ( P < 0.05). Conclusions 3D multiple gradient echo Dixon‐based MRI is a reproducible and sensitive technique which can reveal a significant difference in the fat fraction of thigh muscle, including comparison between Goutallier Grade 0 muscles, between CMT patients and volunteers.

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Section: Discussionmentioning

confidence: 99%

Muscle fat quantification using magnetic resonance imaging: case–control study of Charcot–Marie–Tooth disease patients and volunteers

Kim

Yoon

Choi

et al. 2019

J cachexia sarcopenia muscle

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“…The major advantage of GRE‐based sequences, especially those using a 3D acquisition, over SVS is that simultaneous fat and iron quantification can be performed for the whole liver in one breath‐hold, in a clinical setting. However, separating the fat and water signal contributions may be challenging with iron overload . The inherent capability of MRS to directly differentiate between fat and water spectral components led to its use as a reference standard for fat quantification .…”

Section: Discussionmentioning

confidence: 99%

“…There have been some studies focused on simultaneous R Ã 2 and fat evaluation. 9,14,[35][36][37] The major advantage of GRE-based sequences, especially those using a 3D acquisition, over SVS is that simultaneous fat and iron quantification can be performed for the whole liver in one breathhold, in a clinical setting. However, separating the fat and water signal contributions may be challenging with iron overload.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, promising methods for the simultaneous estimation of FF and

{normalR}_{2}^{*}

by using 3D multi‐echo Dixon methods were described . However, as mentioned in Henninger et al, fat/water swaps may occur for Dixon techniques in patients with a higher LIC. Therefore, the implementation of the simultaneous estimation of FF and

{normalR}_{2}^{*}

, applied to patients with iron overload, may need improvement to make it more robust in clinical practice.…”

mentioning

confidence: 99%

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Quantitative analysis of hepatic iron in patients suspected of coexisting iron overload and steatosis using multi‐echo single‐voxel magnetic resonance spectroscopy: Comparison with fat‐saturated multi‐echo gradient echo sequence

Lin

Kannengießer

et al. 2018

Magnetic Resonance Imaging

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“…Patients were classified by the authors into four fibrosis stages according to their mean stiffness value, based on values from the actual literature [10,11]: F0 = 0-2.5 kPa, F1 = 2.5-3 kPa, F2 = 3-4.4 kPa, F3 = 4.4-7 kPa, and F4 > 7 kPa. Hepatic R2* values were obtained from R2* maps provided by the t1 vibe q-dixon sequence at identical slice positions and checked for iron overload [12] based on the classification recommended by the EASL International Consensus Conference on Haemochromatosis [13].…”

Section: Discussionmentioning

confidence: 99%

Does gadoxetate disodium affect MRE measurements in the delayed hepatobiliary phase?

et al. 2018

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Objectives To assess if the administration of gadoxetate disodium (Gd-EOB-DTPA) significantly affects hepatic magnetic resonance elastography (MRE) measurements in the delayed hepatobiliary phase (DHBP). Methods A total of 47 patients (15 females, 32 males; age range 23-78 years, mean 54.28 years) were assigned to standard hepatic magnetic resonance imaging (MRI) with application of Gd-EOB-DTPA and hepatic MRE. MRE was performed before injection of Gd-EOB-DTPA and after 40-50 min in the DHBP. Liver stiffness values were obtained before and after contrast media application and differences between pre-and post-Gd-EOB-DTPA values were evaluated using a Bland-Altman plot and the Mann-Whitney-Wilcoxon test. In addition, the data were compared with regard to the resulting fibrosis classification. Results Mean hepatic stiffness for pre-Gd-EOB-DTPA measurements was 4.01 kPa and post-Gd-EOB-DTPA measurements yielded 3.95 kPa. We found a highly significant individual correlation between pre-and post-Gd-EOB-DTPA stiffness values (Pearson correlation coefficient of r = 0.95 (p < 0.001) with no significant difference between the two measurements (p =0.49)). Bland-Altman plot did not show a systematic effect for the difference between pre-and post-stiffness measurements (mean difference: 0.06 kPa, SD 0.81). Regarding the classification of fibrosis stages, the overall agreement was 87.23% and the intraclass correlation coefficient was 96.4%, indicating excellent agreement. Conclusions Administration of Gd-EOB-DTPA does not significantly influence MRE stiffness measurements of the liver in the DHBP. Therefore, MRE can be performed in the DHBP. Key Points • MRE of the liver can reliably be performed in the delayed hepatobiliary phase.• Gd-EOB-DTPA does not significantly influence MRE stiffness measurements of the liver.• MRE performed in the delayed hepatobiliary-phase is reasonable in patients with reduced liver function.

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3D Multiecho Dixon for the Evaluation of Hepatic Iron and Fat in a Clinical Setting

Abstract: 1. Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;46:793-800.

Cited by 46 publications

References 41 publications

Muscle fat quantification using magnetic resonance imaging: case–control study of Charcot–Marie–Tooth disease patients and volunteers

Muscle fat quantification using magnetic resonance imaging: case–control study of Charcot–Marie–Tooth disease patients and volunteers

Quantitative analysis of hepatic iron in patients suspected of coexisting iron overload and steatosis using multi‐echo single‐voxel magnetic resonance spectroscopy: Comparison with fat‐saturated multi‐echo gradient echo sequence

Does gadoxetate disodium affect MRE measurements in the delayed hepatobiliary phase?

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