3D nanocomposite alginate hydrogel loaded with pitavastatin nanovesicles as a functional wound dressing with controlled drug release; preparation, in-vitro and in-vivo evaluation

Eldeeb, Alaa Emad; Salah, Samia; Amer, Mona G.; Elkasabgy, Nermeen A.

doi:10.1016/j.jddst.2022.103292

Cited by 17 publications

(21 citation statements)

References 84 publications

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“…In some dressing materials (electrospun, 3D composites, patches and hydrogels) known amount of drug is added into the solution used for preparation of these dressings but the entire preparation solution is not converted into the dressing and the drug may be lost during preparation steps. For such dressing materials, drug EE can be estimated by dissolving known weight of the drug-loaded dressing in suitable solvent, quantifying the total amount of drug present using appropriate assay technique and calculating EE (%) using the equation [ 201 , 202 , 203 , 204 ].

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Section: In Vitro Characterization Methods For Wound Dressing Materialsmentioning

confidence: 99%

In Vitro and In Vivo Characterization Methods for Evaluation of Modern Wound Dressings

Ahmad

2022

Pharmaceutics

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Chronic wound management represents a major challenge in the healthcare sector owing to its delayed wound-healing process progression and huge financial burden. In this regard, wound dressings provide an appropriate platform for facilitating wound healing for several decades. However, adherent traditional wound dressings do not provide effective wound healing for highly exudating chronic wounds and need the development of newer and innovative wound dressings to facilitate accelerated wound healing. In addition, these dressings need frequent changing, resulting in more pain and discomfort. In order to overcome these issues, a wide range of affordable and innovative modern wound dressings have been developed and explored recently to accelerate and improve the wound healing process. However, a comprehensive understanding of various in vitro and in vivo characterization methods being utilized for the evaluation of different modern wound dressings is lacking. In this context, an overview of modern dressings and their complete in vitro and in vivo characterization methods for wound healing assessment is provided in this review. Herein, various emerging modern wound dressings with advantages and challenges have also been reviewed. Furthermore, different in vitro wound healing assays and in vivo wound models being utilized for the evaluation of wound healing progression and wound healing rate using wound dressings are discussed in detail. Finally, a summary of modern wound dressings with challenges and the future outlook is highlighted.

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…”

Section: In Vitro Characterization Methods For Wound Dressing Materialsmentioning

confidence: 99%

In Vitro and In Vivo Characterization Methods for Evaluation of Modern Wound Dressings

Ahmad

2022

Pharmaceutics

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“…It can cure in 2–3 months, depending on its depth and size and whether it is in the epidermis or dermis layers of the skin. Acute wounds can be resolved simply by covering the wound and depending on the self-healing mechanism of the body, while burns, infections, leg ulcers, and other chronic wounds are life-threatening because they do not automatically heal quickly [ 1 , 2 , 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Different Curcumin-Loaded Delivery Systems for Wound Healing Applications: A Comprehensive Review

et al. 2022

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Curcumin or turmeric is the active constituent of Curcuma longa L. It has marvelous medicinal applications in many diseases. When the skin integrity is compromised due to either acute or chronic wounds, the body initiates several steps leading to tissue healing and skin barrier function restoration. Curcumin has very strong antibacterial and antifungal activities with powerful wound healing ability owing to its antioxidant activity. Nevertheless, its poor oral bioavailability, low water solubility and rapid metabolism limit its medical use. Tailoring suitable drug delivery systems for carrying curcumin improves its pharmaceutical and pharmacological effects. This review summarizes the most recent reported curcumin-loaded delivery systems for wound healing purposes, chiefly hydrogels, films, wafers, and sponges. In addition, curcumin nanoformulations such as nanohydrogels, nanoparticles and nanofibers are also presented, which offer better solubility, bioavailability, and sustained release to augment curcumin wound healing effects through stimulating the different healing phases by the aid of the small carrier.

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“…In contrast, groups treated with plain alginate hydrogel and drug suspension, respectively, showed incomplete development of skin structures. While the control group (untreated) showed incomplete wound healing, in addition, a clear wound gap was seen [43].…”

Section: Alginatesmentioning

confidence: 95%

“…Ca 2+ ). The crosslinking occurs through the interaction of each Ca 2+ ion with two opposing L-guluronic acid blocks, forming a crosslinked network identified as "egg-box" conformation [42][43][44][45]. Alginate is listed as a generally regarded safe (GRAS) substance by the FDA [46] with outstanding properties.…”

Section: Alginatesmentioning

confidence: 99%

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Biomaterials for Tissue Engineering Applications and Current Updates in the Field: A Comprehensive Review

2022

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Tissue engineering has emerged as an interesting field nowadays; it focuses on accelerating the auto-healing mechanism of tissues rather than organ transplantation. It involves implanting an In Vitro cultured initiative tissue or a scaffold loaded with tissue regenerating ingredients at the damaged area. Both techniques are based on the use of biodegradable, biocompatible polymers as scaffolding materials which are either derived from natural (e.g. alginates, celluloses, and zein) or synthetic sources (e.g. PLGA, PCL, and PLA). This review discusses in detail the recent applications of different biomaterials in tissue engineering highlighting the targeted tissues besides the in vitro and in vivo key findings. As well, smart biomaterials (e.g. chitosan) are fascinating candidates in the field as they are capable of elucidating a chemical or physical transformation as response to external stimuli (e.g. temperature, pH, magnetic or electric fields). Recent trends in tissue engineering are summarized in this review highlighting the use of stem cells, 3D printing techniques, and the most recent 4D printing approach which relies on the use of smart biomaterials to produce a dynamic scaffold resembling the natural tissue. Furthermore, the application of advanced tissue engineering techniques provides hope for the researchers to recognize COVID-19/host interaction, also, it presents a promising solution to rejuvenate the destroyed lung tissues. Graphical abstract

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3D nanocomposite alginate hydrogel loaded with pitavastatin nanovesicles as a functional wound dressing with controlled drug release; preparation, in-vitro and in-vivo evaluation

Cited by 17 publications

References 84 publications

In Vitro and In Vivo Characterization Methods for Evaluation of Modern Wound Dressings

In Vitro and In Vivo Characterization Methods for Evaluation of Modern Wound Dressings

Different Curcumin-Loaded Delivery Systems for Wound Healing Applications: A Comprehensive Review

Biomaterials for Tissue Engineering Applications and Current Updates in the Field: A Comprehensive Review

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