3D numerical simulation of real-time temperature field in a hyperthermia cancer treatment using OcTree meshes

Valente, André; Peters, Franciane Conceição; Souza, Raphael Vieira Menezes de; Mansur, Webe João

doi:10.1007/s40430-020-02760-1

Cited by 3 publications

(1 citation statement)

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“…In this study, we evaluated the heat distribution of the hyperthermia process using Pennes’ model. The low computational cost and reasonable precision of this model justified its choice [ 5 , 13 , 14 , 15 , 16 , 17 , 18 ]. The original Pennes equation can be modified to model hyperthermia processes, including the role of magnetic nanoparticles in the bioheat transfer equation [ 19 , 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

A 3D Approach Using a Control Algorithm to Minimize the Effects on the Healthy Tissue in the Hyperthermia for Cancer Treatment

Fatigate

Lobosco

Reis

2023

Entropy

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According to the World Health Organization, cancer is a worldwide health problem. Its high mortality rate motivates scientists to study new treatments. One of these new treatments is hyperthermia using magnetic nanoparticles. This treatment consists in submitting the target region with a low-frequency magnetic field to increase its temperature over 43 °C, as the threshold for tissue damage and leading the cells to necrosis. This paper uses an in silico three-dimensional Pennes’ model described by a set of partial differential equations (PDEs) to estimate the percentage of tissue damage due to hyperthermia. Differential evolution, an optimization method, suggests the best locations to inject the nanoparticles to maximize tumor cell death and minimize damage to healthy tissue. Three different scenarios were performed to evaluate the suggestions obtained by the optimization method. The results indicate the positive impact of the proposed technique: a reduction in the percentage of healthy tissue damage and the complete damage of the tumors were observed. In the best scenario, the optimization method was responsible for decreasing the healthy tissue damage by 59% when the nanoparticles injection sites were located in the non-intuitive points indicated by the optimization method. The numerical solution of the PDEs is computationally expensive. This work also describes the implemented parallel strategy based on CUDA to reduce the computational costs involved in the PDEs resolution. Compared to the sequential version executed on the CPU, the proposed parallel implementation was able to speed the execution time up to 84.4 times.

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Section: Introductionmentioning

confidence: 99%

A 3D Approach Using a Control Algorithm to Minimize the Effects on the Healthy Tissue in the Hyperthermia for Cancer Treatment

Fatigate

Lobosco

Reis

2023

Entropy

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Tissue Damage Control Algorithm for Hyperthermia Based Cancer Treatments

Fatigate,

Neves,

Lobosco

et al. 2022

Lecture Notes in Computer Science

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SURFACE MORPHOLOGY OF SILICON NITRIDE (Si₃N₄)-TITANIUM NITRIDE (TiN) COMPOSITES USING GRA-RSM STRATEGY ENCOMPASSED WITH EDMed PARAMETERS

SELVARAJAN,

VENKATARAMANAN,

KANNAN

et al. 2024

Surf. Rev. Lett.

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This investigation explores the application of electrical discharge machining (EDM) to ceramic composites constructed from Si3N4–TiN (Syalon 501) by testing both square and cylindrical electrodes. Various experimental methods have been employed, including design-of-experiments (DoE), Grey relational analysis (GRA), analysis of variance (ANOVA), confirmation testing, and scanning electron microscopy (SEM), in an effort to optimize machining settings and comprehend their effect on performance. While ANOVA revealed crucial parameter levels influencing overall machining conditions as measured by the grey relational grade (GRG), the sophisticated method of GRA considerably improved the machining characteristics. Significant improvements in the EDM process were shown experimentally, resulting in outstanding results for material removal rate (MRR), surface roughness (SR), and electrode wear rate (EWR). In particular, numerous benefits of the square electrode layout over the more common cylindrical arrangement stood out. All of the aforementioned resulted in an impressively high MRR (measured at 0.0281[Formula: see text]gm/min), a low EWR (at 0.0020[Formula: see text]gm/min), and a significant improvement in SR (at 0.3150[Formula: see text][Formula: see text]m). The GRG value was 0.0163 for the square electrode design, which was excellent, and 0.0025 for the cylindrical electrode, which was significantly better. The optimized parameters were successfully used, especially with the square electrode arrangement, leading to significant improvements in MRR and decreases in EWR. On the other hand, surface quality was negatively affected by larger parameter values, which increased the development of microfractures, particularly when using the square electrode design. In any case, our study provides strong proof that adjusted settings can greatly improve EDM performance, allowing for accurate machining of Si3N4–TiN composites with increased MRR, great surface texture, and reduced electrode wear. In conclusion, our study provides useful information to improve EDM procedures for Si3N4–TiN ceramic composites, as well as practical insights into increasing the efficiency and quality of EDM operations in a variety of industrial sectors.

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3D numerical simulation of real-time temperature field in a hyperthermia cancer treatment using OcTree meshes

Cited by 3 publications

References 27 publications

A 3D Approach Using a Control Algorithm to Minimize the Effects on the Healthy Tissue in the Hyperthermia for Cancer Treatment

A 3D Approach Using a Control Algorithm to Minimize the Effects on the Healthy Tissue in the Hyperthermia for Cancer Treatment

Tissue Damage Control Algorithm for Hyperthermia Based Cancer Treatments

SURFACE MORPHOLOGY OF SILICON NITRIDE (Si₃N₄)-TITANIUM NITRIDE (TiN) COMPOSITES USING GRA-RSM STRATEGY ENCOMPASSED WITH EDMed PARAMETERS

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3D numerical simulation of real-time temperature field in a hyperthermia cancer treatment using OcTree meshes

Cited by 3 publications

References 27 publications

A 3D Approach Using a Control Algorithm to Minimize the Effects on the Healthy Tissue in the Hyperthermia for Cancer Treatment

A 3D Approach Using a Control Algorithm to Minimize the Effects on the Healthy Tissue in the Hyperthermia for Cancer Treatment

Tissue Damage Control Algorithm for Hyperthermia Based Cancer Treatments

SURFACE MORPHOLOGY OF SILICON NITRIDE (Si3N4)-TITANIUM NITRIDE (TiN) COMPOSITES USING GRA-RSM STRATEGY ENCOMPASSED WITH EDMed PARAMETERS

Contact Info

Product

Resources

About

SURFACE MORPHOLOGY OF SILICON NITRIDE (Si₃N₄)-TITANIUM NITRIDE (TiN) COMPOSITES USING GRA-RSM STRATEGY ENCOMPASSED WITH EDMed PARAMETERS