3D-Printed Modified-Release Tablets: A Review of the Recent Advances

Siamidi, Angeliki; Tsintavi, Eleni; Rekkas, Dimitrios M.; Vlachou, Marilena

doi:10.5772/intechopen.90868

Cited by 11 publications

(4 citation statements)

References 38 publications

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“…The history of 3D printing is relatively recent, dating back to the 1980s. Significant technological developments have taken place over the years ( Figure 1 ), culminating in the development of Spritam ® , the first commercial 3D-printed oral drug to be approved by the FDA in 2015 [ 2 ]. Two years later, the FDA published “Technical Considerations for Additive Manufactured Medical Devices”, a guide for industry and Food and Drug Administration staff, and progress still continues in this promising area [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

3D-Printed Oral Dosage Forms: Mechanical Properties, Computational Approaches and Applications

et al. 2021

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The aim of this review is to present the factors influencing the mechanical properties of 3D-printed oral dosage forms. It also explores how it is possible to use specific excipients and printing parameters to maintain the structural integrity of printed drug products while meeting the needs of patients. Three-dimensional (3D) printing is an emerging manufacturing technology that is gaining acceptance in the pharmaceutical industry to overcome traditional mass production and move toward personalized pharmacotherapy. After continuous research over the last thirty years, 3D printing now offers numerous opportunities to personalize oral dosage forms in terms of size, shape, release profile, or dose modification. However, there is still a long way to go before 3D printing is integrated into clinical practice. 3D printing techniques follow a different process than traditional oral dosage from manufacturing methods. Currently, there are no specific guidelines for the hardness and friability of 3D printed solid oral dosage forms. Therefore, new regulatory frameworks for 3D-printed oral dosage forms should be established to ensure that they meet all appropriate quality standards. The evaluation of mechanical properties of solid dosage forms is an integral part of quality control, as tablets must withstand mechanical stresses during manufacturing processes, transportation, and drug distribution as well as rough handling by the end user. Until now, this has been achieved through extensive pre- and post-processing testing, which is often time-consuming. However, computational methods combined with 3D printing technology can open up a new avenue for the design and construction of 3D tablets, enabling the fabrication of structures with complex microstructures and desired mechanical properties. In this context, the emerging role of computational methods and artificial intelligence techniques is highlighted.

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Section: Introductionmentioning

confidence: 99%

3D-Printed Oral Dosage Forms: Mechanical Properties, Computational Approaches and Applications

et al. 2021

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“…Different 3D printing technologies have been described in the literature to prepare 3DP pills [14][15][16][17]. Fused deposition modelling (FDM) and Semi Solid Extrusion (SSE) are the most straightforward technologies to prepare different mixtures and combinations Pharmaceutics 2021, 13, 907 2 of 16 of drugs and excipients, where the active pharmaceutical ingredient (API) is directly blended with or impregnated in the excipient/carrier to subsequently be processed.…”

Section: Introductionmentioning

confidence: 99%

Direct Powder Extrusion of Paracetamol Loaded Mixtures for 3D Printed Pharmaceutics for Personalized Medicine via Low Temperature Thermal Processing

Mendibil

Tena

Duque³

et al. 2021

Pharmaceutics

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Three-dimensional printed drug development is nowadays an active area in the pharmaceutical industry, where the search for an appropriate edible carrier that permits the thermal processing of the mixture at temperature levels that are safe for the drug is an important field of study. Here, potato starch and hydroxypropyl cellulose based mixtures loaded with paracetamol up to 50% in weight were processed by hot melt extrusion at 85 °C to test their suitability to be thermally processed. The extruded mixtures were tested by liquid chromatography to analyze their release curves and were thermally characterized. The drug recovery was observed to be highly dependent on the initial moisture level of the mixture, the samples being prepared with an addition of water at a ratio of 3% in weight proportional to the starch amount, highly soluble and easy to extrude. The release curves showed a slow and steady drug liberation compared to a commercially available paracetamol tablet, reaching the 100% of recovery at 60 min. The samples aged for 6 weeks showed slower drug release curves compared to fresh samples, this effect being attributable to the loss of moisture. The paracetamol loaded mixture in powder form was used to print pills with different sizes and geometries in a fused deposition modelling three-dimensional printer modified with a commercially available powder extrusion head, showing the potential of this formulation for use in personalized medicine.

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“…3DP has made it possible to manufacture formulations that dissolve quickly in mouth [67,68]. Modified-release tablets include delayed-release, controlled-release, sustained-release and targeted-release.…”

Section: Immediate-and Modified-release Tabletsmentioning

confidence: 99%

Exploring the Potential of 3d Printing in Pharmaceutical Development

KURIL,

AMBEKAR,

NIMASE

et al. 2023

Int J Curr Pharm Sci

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Pharmaceuticals have been transformed by additive manufacturing, often known as three-dimensional printing (3DP) a disruptive technology. The concept of additive manufacturing is examined, with a focus on its potential for quick prototyping, cost savings, and development of customized medicines. In the pharmaceutical industry 3DP is used to develop numerous dosage forms and drug delivery systems including oral films, controlled-release tablets and transdermal patches. It also makes it possible to produce specialized medical prosthetics, implants and gadgets. The applications of various 3DP types such as material extrusion, material jetting, binder jet printing and powder-based procedures like selective laser sintering, are thoroughly covered. This review assesses the compatibility of the common 3DP materials for pharmaceutical applications including hydroxypropyl methylcellulose, hydroxypropyl cellulose, Carbopol and Eudragit. This review article forecasts 3DP prospects and shortcomings. The technology's continued development and use in the pharmaceutical industry and other industries will depend on overcoming regulatory challenges, creating standardized procedures and optimizing material alternatives. By tackling these issues 3DP has a great deal of potential to revolutionize personalized medicine, medical device production and variety of other industries ultimately leading to better patient outcomes and healthcare solutions. Types and principles, materials, applications, scalability, regulatory compliance and potential future challenges are discussed in this review paper.

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3D-Printed Modified-Release Tablets: A Review of the Recent Advances

Cited by 11 publications

References 38 publications

3D-Printed Oral Dosage Forms: Mechanical Properties, Computational Approaches and Applications

3D-Printed Oral Dosage Forms: Mechanical Properties, Computational Approaches and Applications

Direct Powder Extrusion of Paracetamol Loaded Mixtures for 3D Printed Pharmaceutics for Personalized Medicine via Low Temperature Thermal Processing

Exploring the Potential of 3d Printing in Pharmaceutical Development

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