3D Printed Multi-channel Peristaltic Pump with Active Droplet Generator for Lab-on-a-Chip Devices

Hettiarachchi, Samith; Melroy, Gehan; Mudugamuwa, Amith; Perera, Nisal; Sampath, W. H. P.; Amarasinghe, Y. W. R.

doi:10.1007/978-981-16-6128-0_23

Cited by 3 publications

(1 citation statement)

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“…Photolithography and rapid prototyping are the most common fabrication techniques used in fabricating microrobots [124]. Expensive equipment, complex facilities, and tedious tasks are required to perform photolithography processes whereas rapid prototyping techniques have a less complicated approach [125,126]. In terms of mimicking the bacteria flagella, helical microrobots are used.…”

Section: Hydrogelsmentioning

confidence: 99%

A Review on the Motion of Magnetically Actuated Bio-Inspired Microrobots

et al. 2022

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Nature consists of numerous solutions to overcome challenges in designing artificial systems. Various actuation mechanisms have been implemented in microrobots to mimic the motion of microorganisms. Such bio-inspired designs have contributed immensely to microscale developments. Among the actuation mechanisms, magnetic actuation is widely used in bio-inspired microrobotic systems and related propulsion mechanisms used by microrobots to navigate inside a magnetic field and are presented in this review. In addition, the considered robots are in microscale, and they can swim inside a fluidic environment with a low Reynolds number. In relation to microrobotics, mimicry of bacteria flagella, sperm flagella, cilia, and fish are significant. Due to the fact that these biological matters consist of different propulsion mechanisms, the effect of various parameters was investigated in the last decade and the review presents a summary that enhances understanding of the working principle of propulsion mechanisms. In addition, the effect of different parameters on the various speeds of the existing microrobots was analyzed to identify their trends. So, the swimming speeds of the microrobots show an upward trend with increasing body length, frequency, magnetic flux density, and helix angle. Microfabrication techniques play a significant role in the microscale because the device designs are highly dependent on the availability of the techniques. The presented microrobots were manufactured by 3D/4D photolithography and rapid prototyping techniques. Proper materials enable effective fabrication of microrobots using the mentioned techniques. Therefore, magnetically active material types, matrix materials, biocompatible and biodegradable materials are presented in this study. Utilizing biocompatible and biodegradable materials avoids adverse effects to the organs that could occur otherwise. In addition, magnetic field generation is significant for the propulsion of such microrobots. We conclude the review with an overview of the biomimicry of microrobots and magnetically actuated robot propulsion.

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Section: Hydrogelsmentioning

confidence: 99%

A Review on the Motion of Magnetically Actuated Bio-Inspired Microrobots

et al. 2022

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Periodic Flows in Microfluidics

Mudugamuwa,

Roshan,

Hettiarachchi

et al. 2024

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Microfluidics, the science and technology of manipulating fluids in microscale channels, offers numerous advantages, such as low energy consumption, compact device size, precise control, fast reaction, and enhanced portability. These benefits have led to applications in biomedical assays, disease diagnostics, drug discovery, neuroscience, and so on. Fluid flow within microfluidic channels is typically in the laminar flow region, which is characterized by low Reynolds numbers but brings the challenge of efficient mixing of fluids. Periodic flows are time‐dependent fluid flows, featuring repetitive patterns that can significantly improve fluid mixing and extend the effective length of microchannels for submicron and nanoparticle manipulation. Besides, periodic flow is crucial in organ‐on‐a‐chip (OoC) for accurately modeling physiological processes, advancing disease understanding, drug development, and personalized medicine. Various techniques for generating periodic flows have been reported, including syringe pumps, peristalsis, and actuation based on electric, magnetic, acoustic, mechanical, pneumatic, and fluidic forces, yet comprehensive reviews on this topic remain limited. This paper aims to provide a comprehensive review of periodic flows in microfluidics, from fundamental mechanisms to generation techniques and applications. The challenges and future perspectives are also discussed to exploit the potential of periodic flows in microfluidics.

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