3D printed porous titanium filled with mineralized UV-responsive chitosan hydrogel promotes cell proliferation and osteogenesis in vitro

Yang, Jiazhao; Liu, Fan; Zhou, Changshun; Li, Hejie; Yang, Guiling; Fang, Shiyuan; Lee, In-Seop; Liu, Yi; Bai, Hao; Chen, Cen

doi:10.1016/j.jmst.2022.10.008

Cited by 18 publications

(8 citation statements)

References 42 publications

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“…The photo-crosslinked hydrogels also have injectability features, because of gel formation, after they are photo-polymerized. Photo-responsive chitosan hydrogel can be prepared through functionalization with light-sensitive components/precursors, such as 2-amino ethyl methacrylate [ 129 ], methacryloylglycine [ 130 ], glycidyl methacrylate [ 131 , 132 ], and methacrylic anhydride [ 133 , 134 , 135 ]. Then, the functionalized chitosan solution is mixed with a photo-initiator such as 2-hydroxy-2-methylpropiophenone [ 134 ] and lithium phenyl-2,4,6-trimethylbenzoylphosphinate [ 135 ].…”

Section: Gelation Techniques Of Chitosan-based Hydrogelsmentioning

confidence: 99%

“…Photo-responsive chitosan hydrogel can be prepared through functionalization with light-sensitive components/precursors, such as 2-amino ethyl methacrylate [ 129 ], methacryloylglycine [ 130 ], glycidyl methacrylate [ 131 , 132 ], and methacrylic anhydride [ 133 , 134 , 135 ]. Then, the functionalized chitosan solution is mixed with a photo-initiator such as 2-hydroxy-2-methylpropiophenone [ 134 ] and lithium phenyl-2,4,6-trimethylbenzoylphosphinate [ 135 ]. The methacrylic anhydride, which interacts with the amidogen of chitosan through acylation/methacrylation reaction ( Figure 4 A), is often used in the recent literature due to its solubility and a certain degree of cytotoxicity.…”

Section: Gelation Techniques Of Chitosan-based Hydrogelsmentioning

confidence: 99%

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Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Taokaew

Kaewkong

Kriangkrai

2023

Gels

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Chitosan is a promising naturally derived polysaccharide to be used in hydrogel forms for pharmaceutical and biomedical applications. The multifunctional chitosan-based hydrogels have attractive properties such as the ability to encapsulate, carry, and release the drug, biocompatibility, biodegradability, and non-immunogenicity. In this review, the advanced functions of the chitosan-based hydrogels are summarized, with emphasis on fabrications and resultant properties reported in literature from the recent decade. The recent progress in the applications of drug delivery, tissue engineering, disease treatments, and biosensors are reviewed. Current challenges and future development direction of the chitosan-based hydrogels for pharmaceutical and biomedical applications are prospected.

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Section: Gelation Techniques Of Chitosan-based Hydrogelsmentioning

confidence: 99%

Section: Gelation Techniques Of Chitosan-based Hydrogelsmentioning

confidence: 99%

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Taokaew

Kaewkong

Kriangkrai

2023

Gels

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“… Ca-based coating for the 3D printed porous Ti-based implants (especially for internal surface) [ 180 , 181 , 183 ]. ( A : the porous Ti6Al4V scaffold after MAO treatment displayed homogeneous layer of microporous titanium oxides coating containing a significant amount of Ca and P. The thickness of coating at the inner and outer surface were 4.4 and 4.8 μm.…”

Section: Functional Engineering Strategies Of Metallic Materials For ...mentioning

confidence: 99%

“…The fabricated CaCO 3 mineral layer grew inside hydrogels and wrapped up their polymer networks to provide a strong bonding between hydrogel and Ti substrate. Inspired by in situ mineralization method above, our group developed novel modification strategy for porous implants [ 183 ]. In detail, UV-responsive methacrylic anhydride chitosan (CSMA) was filled into 3D printed porous Ti implant, followed by the introduction of CaCl 2 and in situ mineralization by CO 2 diffusion within hydrogel, which could release Ca 2+ continuously, resulting in promoted proliferation and osteogenesis of MSCs in vitro ( Fig.…”

Section: Functional Engineering Strategies Of Metallic Materials For ...mentioning

confidence: 99%

Functional engineering strategies of 3D printed implants for hard tissue replacement

Chen

Huang

Liu

et al. 2022

Regenerative Biomaterials

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3D printing technology with the rapid development of printing materials are widely recognized as a promising way to fabricate bioartificial bone tissues. In consideration of the disadvantages of bone substitutes, including poor mechanical properties, lack of vascularization and insufficient osteointegration, functional modification strategies can provide multiple functions and desired characteristics of printing materials, enhance their physicochemical and biological properties in bone tissue engineering. Thus, this review focuses on the advances of functional engineering strategies for 3D printed biomaterials in hard tissue replacement. It is structured as introducing 3D printing technologies, properties of printing materials (metals, ceramics and polymers) and typical functional engineering strategies utilized in the application of bone, cartilage and joint regeneration.

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“…The size and shape of these pores and voids can be controlled by regulating the conditions and preparation process during gel synthesis. By regulating the structure of the pores, it is possible to match them with surrounding tissues, promoting cell adhesion and growth [9,10]. Moreover, hydrogels exhibit excellent antimicrobial properties in oral clinical applications.…”

Section: Introductionmentioning

confidence: 99%

Hydrogels for Oral Tissue Engineering: Challenges and Opportunities

Chen,

Deng,

Lai

et al. 2023

Molecules

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Oral health is crucial to daily life, yet many people worldwide suffer from oral diseases. With the development of oral tissue engineering, there is a growing demand for dental biomaterials. Addressing oral diseases often requires a two-fold approach: fighting bacterial infections and promoting tissue growth. Hydrogels are promising tissue engineering biomaterials that show great potential for oral tissue regeneration and drug delivery. In this review, we present a classification of hydrogels commonly used in dental research, including natural and synthetic hydrogels. Furthermore, recent applications of these hydrogels in endodontic restorations, periodontal tissues, mandibular and oral soft tissue restorations, and related clinical studies are also discussed, including various antimicrobial and tissue growth promotion strategies used in the dental applications of hydrogels. While hydrogels have been increasingly studied in oral tissue engineering, there are still some challenges that need to be addressed for satisfactory clinical outcomes. This paper summarizes the current issues in the abovementioned application areas and discusses possible future developments.

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3D printed porous titanium filled with mineralized UV-responsive chitosan hydrogel promotes cell proliferation and osteogenesis in vitro

Cited by 18 publications

References 42 publications

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Functional engineering strategies of 3D printed implants for hard tissue replacement

Hydrogels for Oral Tissue Engineering: Challenges and Opportunities

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