3D printing applications for transdermal drug delivery

Economidou, Sophia N.; Lamprou, Dimitrios A.; Douroumis, Dennis

doi:10.1016/j.ijpharm.2018.01.031

Cited by 207 publications

(116 citation statements)

References 54 publications

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“…Among the various technologies that comprise 3D printing, photopolymerisation-based techniques enable the fabrication of structures through the consecutive layer-wise polymerization of UV-sensitive polymers, through a curing process named photopolymerization. Stereolithography (SLA), Digital Light Processing (DLP) and Two-Photon-Polymerization (2PP) are among these technologies (Economidou et al, 2018). In the field of Transdermal Drug Delivery (TDD), Gittard et al employed a photopolymerisationbased printer (DLP) to fabricate MNs of various geometries for wound healing applications followed by pulse laser deposition of silver and zinc oxide thin films (Gittard et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

3D printed microneedles for insulin skin delivery

Pere

Economidou

Lall

et al. 2018

International Journal of Pharmaceutics

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279

164

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In this study, polymeric microneedle patches were fabricated by stereolithography, a 3D printing technique, for the transdermal delivery of insulin. A biocompatible resin was photopolymerized to build pyramid and cone microneedle designs followed by inkjet print coating of insulin formulations. Trehalose, mannitol and xylitol were used as drug carriers with the aim to preserve insulin integrity and stability but also to facilitate rapid release rates. Circular dichroism and Raman analysis demonstrated that all carriers maintained the native form of insulin, with xylitol presenting the best performance. Franz cell release studies were used for in vitro determination of insulin release rates in porcine skin. Insulin was released rapidly within 30 min irrespectively of the microneedle design. 3D printing was proved an effective technology for the fabrication of biocompatible and scalable microneedle patches.

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Section: Introductionmentioning

confidence: 99%

3D printed microneedles for insulin skin delivery

Pere

Economidou

Lall

et al. 2018

International Journal of Pharmaceutics

Self Cite

279

164

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“…Among mold-free technologies, additive manufacturing, or 3D printing, has been shown to be an emerging field in MN structure fabrication. In fact, employing Computer Aided Design (CAD) software allows the design of MNs with costumed density, length, and geometry, which can be printed with high reproducibility through the consecutive deposition of layers [42]. Additive manufacturing involves different technologies to produce MNs.…”

Section: Mold-free Methodsmentioning

confidence: 99%

Progress in Microneedle-Mediated Protein Delivery

Jamaledin

Natale

Onesto

et al. 2020

JCM

102

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The growing demand for patient-compliance therapies in recent years has led to the development of transdermal drug delivery, which possesses several advantages compared with conventional methods. Delivering protein through the skin by transdermal patches is extremely difficult due to the presence of the stratum corneum which restricts the application to lipophilic drugs with relatively low molecular weight. To overcome these limitations, microneedle (MN) patches, consisting of micro/miniature-sized needles, are a promising tool to perforate the stratum corneum and to release drugs and proteins into the dermis following a non-invasive route. This review investigates the fabrication methods, protein delivery, and translational considerations for the industrial scaling-up of polymeric MNs for dermal protein delivery.

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“…[83,84] The currently commonly utilized manufacturing technologies of 3D printing for the fabrication of polymeric microneedles mainly include inkjet printing, photopolymerization-based technique, and fused deposition modelling (FDM). [85] Inkjet printing could achieve controllable and selective deposition of drug droplets onto microneedle surface by numerous thermal or piezoelectric-driven printing heads. [86] Currently, such technique has been main utilized to coat pre-fabricated microneedles with drugs for the personalized and combined drug loading.…”

Section: Methods For the Fabrication Of Polymeric Microneedlesmentioning

confidence: 99%

“…However, there are some major disadvantages of such technology, such as poor resolution, and limited variety of substitute materials. [85,95] Currently its applications in microneedle fabrication are still limited in literature. Nevertheless, FDM is still an appealing method as the fabrication process eliminates the use of solvents.…”

Section: Methods For the Fabrication Of Polymeric Microneedlesmentioning

confidence: 99%

Biomedical Applications of Polymeric Microneedles for Transdermal Therapeutic Delivery and Diagnosis: Current Status and Future Perspectives

Liu

Luo

Xing

2020

Advanced Therapeutics

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Transdermal drug delivery is a crucial extension of drug administration routes and has been widely acknowledged as an alternative way to traditional oral administration and subcutaneous injections due to the advantages such as increased dosage efficacy, decreased systemic side effect, and improved patient compliance. The past few decades have witnessed biomedical applications of microneedles in various cutting‐edge fields. Microneedles are needles with micron‐scale length which can pierce the epidermis of the skin in a minimally invasive manner for transdermal drug delivery. Compared with inorganic and metal microneedles, polymeric microneedles have attracted more attention because of their superior biocompatibility, nontoxicity, and biodegradability. In this review, the state‐of‐art and future biomedical applications of polymeric microneedles are summarized. First of all, a brief introduction to the polymeric microneedles, including types of polymeric microneedles and methods for the fabrication is included. Then the biomedical applications of polymeric microneedles in transdermal drug delivery and diagnosis are summarized in detail. Finally, discussions on the current limitations and future perspectives of polymeric microneedles are provided.

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3D printing applications for transdermal drug delivery

Cited by 207 publications

References 54 publications

3D printed microneedles for insulin skin delivery

3D printed microneedles for insulin skin delivery

Progress in Microneedle-Mediated Protein Delivery

Biomedical Applications of Polymeric Microneedles for Transdermal Therapeutic Delivery and Diagnosis: Current Status and Future Perspectives

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