3D printing‐based drug-loaded implanted prosthesis to prevent breast cancer recurrence post‐conserving surgery

Hao, Wenyan; Zheng, Zhiming; Zhu, Lin; Pang, Lulu; Ma, Jinqiu; Zhu, Siqing; Du, Lina; Jin, Yiguang

doi:10.1016/j.ajps.2020.06.002

Cited by 24 publications

(11 citation statements)

References 35 publications

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“…For this purpose, the implant mold was designed and produced by 3DP to confer customizability. In vivo studies conducted on mice suggested that the system could prevent recurrence and metastasis formation in mice [ 111 ].…”

Section: Three-dimensional Printing In the Fight Against Breast Cancermentioning

confidence: 99%

3D and 4D Printing in the Fight against Breast Cancer

2022

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Breast cancer is the second most common cancer worldwide, characterized by a high incidence and mortality rate. Despite the advances achieved in cancer management, improvements in the quality of life of breast cancer survivors are urgent. Moreover, considering the heterogeneity that characterizes tumors and patients, focusing on individuality is fundamental. In this context, 3D printing (3DP) and 4D printing (4DP) techniques allow for a patient-centered approach. At present, 3DP applications against breast cancer are focused on three main aspects: treatment, tissue regeneration, and recovery of the physical appearance. Scaffolds, drug-loaded implants, and prosthetics have been successfully manufactured; however, some challenges must be overcome to shift to clinical practice. The introduction of the fourth dimension has led to an increase in the degree of complexity and customization possibilities. However, 4DP is still in the early stages; thus, research is needed to prove its feasibility in healthcare applications. This review article provides an overview of current approaches for breast cancer management, including standard treatments and breast reconstruction strategies. The benefits and limitations of 3DP and 4DP technologies are discussed, as well as their application in the fight against breast cancer. Future perspectives and challenges are outlined to encourage and promote AM technologies in real-world practice.

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Section: Three-dimensional Printing In the Fight Against Breast Cancermentioning

confidence: 99%

3D and 4D Printing in the Fight against Breast Cancer

2022

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“…Based on 3D printing, a prosthesis containing paclitaxel and doxorubicin microspheres (PPDM) was fabricated with an average particle size of 3.1 µm and 2.2 µm. The microspheres effectively suppressed breast cancer recurrence and metastasis in the xenograft mice model [177]. In a study, a 3D printed liver model was developed using patients' CT images, which were transformed into stereolithographic files, printed using a desktop 3D printer, and were assembled and filled with silicone.…”

Section: Cancer Metastasis and 3d Printingmentioning

confidence: 99%

Three-Dimensional (3D) Printing in Cancer Therapy and Diagnostics: Current Status and Future Perspectives

Safhi

2022

Pharmaceuticals

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Three-dimensional (3D) printing is a technique where the products are printed layer-by-layer via a series of cross-sectional slices with the exact deposition of different cell types and biomaterials based on computer-aided design software. Three-dimensional printing can be divided into several approaches, such as extrusion-based printing, laser-induced forward transfer-based printing systems, and so on. Bio-ink is a crucial tool necessary for the fabrication of the 3D construct of living tissue in order to mimic the native tissue/cells using 3D printing technology. The formation of 3D software helps in the development of novel drug delivery systems with drug screening potential, as well as 3D constructs of tumor models. Additionally, several complex structures of inner tissues like stroma and channels of different sizes are printed through 3D printing techniques. Three-dimensional printing technology could also be used to develop therapy training simulators for educational purposes so that learners can practice complex surgical procedures. The fabrication of implantable medical devices using 3D printing technology with less risk of infections is receiving increased attention recently. A Cancer-on-a-chip is a microfluidic device that recreates tumor physiology and allows for a continuous supply of nutrients or therapeutic compounds. In this review, based on the recent literature, we have discussed various printing methods for 3D printing and types of bio-inks, and provided information on how 3D printing plays a crucial role in cancer management.

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“…Paclitaxel and doxorubicin containing polydimethysiloxane carrier prosthesis successfully delivered the drugs for more than 3 weeks. The 3D printed personalized prosthesis inhibited breast tumour recurrence and metastasis in mice (80). Three-dimensional printed microneedles printed by stereolithography with various anticancer agents have been majorly studied for skin cancer to promote localized drug delivery.…”

Section: Three-dimensional Printed Personalized Drug Delivery For Cancermentioning

confidence: 99%

3D Printed Personalized Medicine for Cancer: Applications for Betterment of Diagnosis, Prognosis and Treatment

2021

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Cancer treatment is challenging due to the tumour heterogeneity that makes personalized medicine a suitable technique for providing better cancer treatment. Personalized medicine analyses patient-related factors like genetic make-up and lifestyle and designs treatments that offer the benefits of reduced side effects and efficient drug delivery. Personalized medicine aims to provide a holistic way for prevention, diagnosis and treatment. The customization desired in personalized medicine is produced accurately by 3D printing which is an established technique known for its precision. Different 3D printing techniques exhibit their capability in producing cancer-specific medications for breast, liver, thyroid and kidney tumours. Three-dimensional printing displays major influence on cancer modelling and studies using cancer models in treatment and diagnosis. Three-dimensional printed personalized tumour models like physical 3D models, bioprinted models and tumour-onchip models demonstrate better in vitro and in vivo correlation in drug screening, cancer metastasis and prognosis studies. Three-dimensional printing helps in cancer modelling; moreover, it has also changed the facet of cancer treatment. Improved treatment via custommade 3D printed devices, implants and dosage forms ensures the delivery of anticancer agents efficiently. This review covers recent applications of 3D printed personalized medicine in various cancer types and comments on the possible future directions like application of 4D printing and regularization of 3D printed personalized medicine in healthcare.Keywords personalized medicine • Tumour-on-chip • 3D bioprinting • 3D printing • Cancer modelling

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3D printing‐based drug-loaded implanted prosthesis to prevent breast cancer recurrence post‐conserving surgery

Abstract: Highlights The prothesis of paclitaxel and doxorubicin microspheres (PPDM) based on 3D printing to prevent tumor recurrence and metastasis after breast conserving surgery were designed and prepared. Breast reconstruction and chemotherapy were combined together.

Cited by 24 publications

References 35 publications

3D and 4D Printing in the Fight against Breast Cancer

3D and 4D Printing in the Fight against Breast Cancer

Three-Dimensional (3D) Printing in Cancer Therapy and Diagnostics: Current Status and Future Perspectives

3D Printed Personalized Medicine for Cancer: Applications for Betterment of Diagnosis, Prognosis and Treatment

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