3D Printing for Bio-Synthetic Biliary Stents

Boyer, Christen J.; Boktor, Moheb; Samant, Hrishikesh; White, Luke A.; Wang, Yuping; Ballard, David H.; Huebert, Robert C.; Woerner, Jennifer E.; Ghali, Ghali E.; Alexander, Jonathan

doi:10.3390/bioengineering6010016

Cited by 36 publications

(19 citation statements)

References 33 publications

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“…Several studies have shown antibiotics and chemotherapeutics incorporated into 3D printed filaments, catheters, and meshes [9,11,15]. Additional drug-incorporating studies into 3D printed constructs have shown the capability to have implants impregnated with contrast materials [16,17], hormones [8], and act as a scaffold for tissue cultures [18].…”

Section: Discussionmentioning

confidence: 99%

3D Printing Custom Bioactive and Absorbable Surgical Screws, Pins, and Bone Plates for Localized Drug Delivery

Tappa

Jammalamadaka

Weisman

et al. 2019

JFB

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Additive manufacturing has great potential for personalized medicine in osseous fixation surgery, including maxillofacial and orthopedic applications. The purpose of this study was to demonstrate 3D printing methods for the fabrication of patient-specific fixation implants that allow for localized drug delivery. 3D printing was used to fabricate gentamicin (GS) and methotrexate (MTX)-loaded fixation devices, including screws, pins, and bone plates. Scaffolds with different infill ratios of polylactic acid (PLA), both without drugs and impregnated with GS and MTX, were printed into cylindrical and rectangular-shaped constructs for compressive and flexural strength mechanical testing, respectively. Bland PLA constructs showed significantly higher flexural strength when printed in a Y axis at 100% infill compared to other axes and infill ratios; however, there was no significant difference in flexural strength between other axes and infill ratios. GS and MTX-impregnated constructs had significantly lower flexural and compressive strength as compared to the bland PLA constructs. GS-impregnated implants demonstrated bacterial inhibition in plate cultures. Similarly, MTX-impregnated implants demonstrated a cytotoxic effect in osteosarcoma assays. This proof of concept work shows the potential of developing 3D printed screws and plating materials with the requisite mechanical properties and orientations. Drug-impregnated implants were technically successful and had an anti-bacterial and chemotherapeutic effect, but drug addition significantly decreased the flexural and compressive strengths of the custom implants.

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Section: Discussionmentioning

confidence: 99%

3D Printing Custom Bioactive and Absorbable Surgical Screws, Pins, and Bone Plates for Localized Drug Delivery

Tappa

Jammalamadaka

Weisman

et al. 2019

JFB

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“…3D-printed biliary stents using primary mesenchymal stem cells and human cholangiocytes have been reported. 37 Therefore, in the future human biliary organoids might serve as a source of biomaterial used to regenerate damaged bile ducts for patients with PSC or BA. This technology may also allow personalized biostents to be fabricated for patients affected by various cholangiopathies.…”

Section: Biliary Organoids and Regenerative Medicinementioning

confidence: 99%

Role of Biliary Organoids in Cholestasis Research and Regenerative Medicine

2021

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Translational studies in human cholestatic diseases have for years been hindered by various challenges, including the rarity of the disorders, the difficulty in obtaining biliary tissue from across the spectrum of the disease stage, and the difficulty culturing and maintaining primary cholangiocytes. Organoid technology is increasingly being viewed as a technological breakthrough in translational medicine as it allows the culture and biobanking of self-organizing cells from various sources that facilitate the study of pathophysiology and therapeutics, including from individual patients in a personalized approach. This review describes current research using biliary organoids for the study of human cholestatic diseases and the emerging applications of organoids to regenerative medicine directed at the biliary tree. Challenges and possible solutions to the current hurdles in this emerging field, particularly the need for standardization of terminology and clarity on source materials and techniques, are also discussed.

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“…For biliary endoscopy, previous work show 3D printed anatomic models being used primarily in training applications [29,30]. 3D printing has been used in the development of novel biliary stents [54].…”

Section: Hepatobiliarymentioning

confidence: 99%

Radiological Society of North America (RSNA) 3D Printing Special Interest Group (SIG) clinical situations for which 3D printing is considered an appropriate representation or extension of data contained in a medical imaging examination: abdominal, hepatobiliary, and gastrointestinal conditions

et al. 2020

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Background: Medical 3D printing has demonstrated value in anatomic models for abdominal, hepatobiliary, and gastrointestinal conditions. A writing group composed of the Radiological Society of North America (RSNA) Special Interest Group on 3D Printing (SIG) provides appropriateness criteria for abdominal, hepatobiliary, and gastrointestinal 3D printing indications. Methods: A literature search was conducted to identify all relevant articles using 3D printing technology associated with a number of abdominal pathologic processes. Each included study was graded according to published guidelines. Results: Evidence-based appropriateness guidelines are provided for the following areas: intra-hepatic masses, hilar cholangiocarcinoma, biliary stenosis, biliary stones, gallbladder pathology, pancreatic cancer, pancreatitis, splenic disease, gastric pathology, small bowel pathology, colorectal cancer, perianal fistula, visceral trauma, hernia, abdominal sarcoma, abdominal wall masses, and intra-abdominal fluid collections. Conclusion: This document provides initial appropriate use criteria for medical 3D printing in abdominal, hepatobiliary, and gastrointestinal conditions.

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3D Printing for Bio-Synthetic Biliary Stents

Cited by 36 publications

References 33 publications

3D Printing Custom Bioactive and Absorbable Surgical Screws, Pins, and Bone Plates for Localized Drug Delivery

3D Printing Custom Bioactive and Absorbable Surgical Screws, Pins, and Bone Plates for Localized Drug Delivery

Role of Biliary Organoids in Cholestasis Research and Regenerative Medicine

Radiological Society of North America (RSNA) 3D Printing Special Interest Group (SIG) clinical situations for which 3D printing is considered an appropriate representation or extension of data contained in a medical imaging examination: abdominal, hepatobiliary, and gastrointestinal conditions

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