3D Printing for Fast Prototyping of Pharmaceutical Dissolution Testing Equipment for Nonstandard Applications

Abstract

Purpose of the research was to assess feasibility of fused deposition techniques (3D printing) for development of analytical equipment dedicated for specific dosage forms and for nonstandard applications. Dissolution profiles as well as 3D magnetic resonance imaging (MRI) of the buccal tablets during hydration in dissolution medium were analyzed. The principal result of the study was the first working example of rapid 3D prototyping of dedicated, MRI-compatible dissolution equipment for mucoadhesive buccal tablets. Rapid prototyping techniques were found to be a fast, inexpensive way to develop a dedicated dissolution testing setup.