3D printing of high drug loaded dosage forms using thermoplastic polyurethanes

Verstraete, G.; Samaro, Aseel; Grymonpré, W.; Vanhoorne, Valérie; Snick, B. Van; Boone, Matthieu; Hellemans, Tom; Hoorebeke, Luc Van; Remon, Jean Paul

doi:10.1016/j.ijpharm.2017.12.002

Cited by 185 publications

(116 citation statements)

References 33 publications

Supporting

Mentioning

106

Contrasting

Unclassified

Order By: Relevance

“…Fused deposition modelling (FDM) 3D printing has therefore been proposed as an alternative method for 3D printing of tablets [16,17] and medical devices [18]. The method allows the fabrication of immediate [19][20][21], delayed [22,23], extended release tablets [24][25][26][27][28] as well as for dual drug delivery systems [29][30][31]. The technology offers several advantages such as the lower cost, absence of finishing step, small place requirement and obviation for material recycling [13,32].…”

Section: Introductionmentioning

confidence: 99%

‘Temporary Plasticiser’: A novel solution to fabricate 3D printed patient-centred cardiovascular ‘Polypill’ architectures

Pereira

Isreb

Forbes

et al. 2019

European Journal of Pharmaceutics and Biopharmaceutics

162

View full text Add to dashboard Cite

Hypertension and dyslipidaemia are modifiable risk factors associated with cardiovascular diseases (CVDs) and often require a complex therapeutic regimen. The administration of several medicines is commonly associated with poor levels of adherence among patients, to which World Health Organisation (WHO) proposed a fixed-dose combination unit (polypill) as a strategy to improve adherence. In this work, we demonstrate the fabrication of patient-specific polypills for the treatment of CVDs by fused deposition modelling (FDM) 3D printing and introduce a novel solution to meet critical quality attributes. The construction of poly(vinyl alcohol) (PVA)-based polypills containing four model drugs (lisinopril dihydrate, indapamide, rosuvastatin calcium and amlodipine besylate) was revealed for the first time. The impact of tablet architecture was explored using multi-layered and unimatrix structures. The novel approach of using distilled water as a 'temporary co-plasticiser' is reported and was found to significantly lower the extruding (90°C) and 3D printing (150°C) temperatures from 170°C and 210°C respectively, with consequent reduction in thermal stress to the chemicals. XRD indicated that lisinopril dihydrate and amlodipine besylate maintained their crystalline form while indapamide and rosuvastatin calcium were essentially amorphous in the PVA tablets. From the multilayer polypills, the release profile of each drug was dependent on its position in the multilayer.In addition to the multilayer architecture offering a higher flexibility in dose titration and a more adaptive solution to meet the expectations of patient-centred therapy, we identify that it also allows orchestrating the release of drugs of different physicochemical characteristics. Adopting such an approach opens up a pathway towards low-cost multidrug delivery systems such as tablets, stents or implants for wider range of globally approved actives.

show abstract

Section: Introductionmentioning

confidence: 99%

‘Temporary Plasticiser’: A novel solution to fabricate 3D printed patient-centred cardiovascular ‘Polypill’ architectures

Pereira

Isreb

Forbes

et al. 2019

European Journal of Pharmaceutics and Biopharmaceutics

162

View full text Add to dashboard Cite

show abstract

“…Once each individual cross-section of the desired object is completed, the building plate can be moved down (Z direction) to deposit different layers. 4 Polylactic acid (PLA) filaments are widely used as bio-based feedstock for FDM. Although PLA filaments are degradable and exhibit outstanding properties, its brittleness restricts their suitability for orthosis applications.…”

Section: Introductionmentioning

confidence: 99%

Application of a thermoplastic polyurethane/polylactic acid composite filament for 3D-printed personalized orthosis

Tao¹,

Shao²,

Li³

et al. 2019

Mater. Tehnol.

View full text Add to dashboard Cite

For designing and fabricating personalized, cost-effective and biodegradable orthoses, a finger orthosis was chosen as an example to explore a suitable material, personalized design method, and fabrication with a fuse-deposition-modeling (FDM) open-source 3D printer. Thermoplastic polyurethane (TPU)/polylactic acid (PLA) composite filaments were explored for 3D printing. The polymer composite compositions were TPU/PLA: 0 %/100 % (TP0), 25 %/75 % (TP25), and 50 %/50 % (TP50) by weight, respectively. The mechanical performance, thermal properties, and structure of the TPU/PLA composite filaments were assessed by tensile tests, thermal gravimetric analysis (TGA), differential scanning calorimetry (DSC), and powder X-ray diffraction (XRD) measurements. Compared to the neat PLA, the TP25 specimens exhibited almost the same tensile strength, but its higher elongation at the break indicates that TP25 is more suitable for the material of orthoses. However, a further increase of the TPU ratio to 50 % resulted in a sharp decrease of the tensile strength. The addition of TPU had little effect on the starting thermal decomposition temperature, glass-transition temperature, and melting temperature of the composites. The composite filaments can be printed through the normal 3D printing procedure. 3D scanning and open-source 3D printers can be used to complete the design and fabrication of personalized orthoses.

show abstract

“…Even the FFF4 tablet with the highest infill (100%) produced in this study had a lower weight than the IM tablet, which is an indication of the matrix porosity differences between samples produced using these methods (Verstraete et al, 2018).…”

Section: Physical Propertiesmentioning

confidence: 77%

“…Despite the technical hurdles, there is a growing interest in the utilization of the technology for pharmaceutical applications (Jamróz et al, 2017;Norman et al, 2017;Prasad and Smyth, 2016). Researchers have investigated the use of the process to make oral dosage forms such as tablets (Beck et al, 2017;Chai et al, 2017;Goyanes et al, 2015bGoyanes et al, , 2015cGoyanes et al, , 2014Long et al, 2017;Okwuosa et al, 2016;Solanki et al, 2018;Verstraete et al, 2018),caplets (Goyanes et al, 2016b(Goyanes et al, , 2015d, among other more intricate geometries, compositions and functions (Genina et al, 2017;Maroni et al, 2017;Melocchi et al, 2015;Sadia et al, 2018). Other than the ready production of tablets with complex shapes, a primary driver for the technology is the possibility of the tailored dosage forms to enable the personalisation of treatment (Konta et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Comparison of fused-filament fabrication to direct compression and injection molding in the manufacture of oral tablets

Fuenmayor

Forde

Healy

et al. 2019

International Journal of Pharmaceutics

View full text Add to dashboard Cite

3D printing of high drug loaded dosage forms using thermoplastic polyurethanes

Cited by 185 publications

References 33 publications

‘Temporary Plasticiser’: A novel solution to fabricate 3D printed patient-centred cardiovascular ‘Polypill’ architectures

‘Temporary Plasticiser’: A novel solution to fabricate 3D printed patient-centred cardiovascular ‘Polypill’ architectures

Application of a thermoplastic polyurethane/polylactic acid composite filament for 3D-printed personalized orthosis

Comparison of fused-filament fabrication to direct compression and injection molding in the manufacture of oral tablets

Contact Info

Product

Resources

About