3D printing of multi-functional artificial conduits against acute thrombosis and clinical infection

Wang, Huajie; Mao, Qiu-Yue; Liu, Chang; Hao, Meng-Fei; Meng, Zhi-Fen; Li, Shumei; Zhang, Yuping; Wang, Jin‐Ye

doi:10.1016/j.compositesb.2021.109497

Cited by 12 publications

(3 citation statements)

References 43 publications

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“…Many researchers [ 26 , 27 ] have proved that 3D printing of artificial blood vessels is expected to become an effective method for the treatment of cardiovascular and cerebrovascular diseases. However, the current 3D printing technology of artificial blood vessels has not formed a unified and complete process, resulting in the poor controllability of artificial blood vessel molding, which seriously affects the quality of the vascular structure molding [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Hydrogel Contact Angle on Wall Thickness of Artificial Blood Vessel

Jin

Liu

Nie

et al. 2022

IJMS

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Vascular replacement is one of the most effective tools to solve cardiovascular diseases, but due to the limitations of autologous transplantation, size mismatch, etc., the blood vessels for replacement are often in short supply. The emergence of artificial blood vessels with 3D bioprinting has been expected to solve this problem. Blood vessel prosthesis plays an important role in the field of cardiovascular medical materials. However, a small-diameter blood vessel prosthesis (diameter < 6 mm) is still unable to achieve wide clinical application. In this paper, a response surface analysis was firstly utilized to obtain the relationship between the contact angle and the gelatin/sodium alginate mixed hydrogel solution at different temperatures and mass percentages. Then, the self-developed 3D bioprinter was used to obtain the optimal printing spacing under different conditions through row spacing, printing, and verifying the relationship between the contact angle and the printing thickness. Finally, the relationship between the blood vessel wall thickness and the contact angle was obtained by biofabrication with 3D bioprinting, which can also confirm the controllability of the vascular membrane thickness molding. It lays a foundation for the following study of the small caliber blood vessel printing molding experiment.

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Section: Discussionmentioning

confidence: 99%

Effect of Hydrogel Contact Angle on Wall Thickness of Artificial Blood Vessel

Jin

Liu

Nie

et al. 2022

IJMS

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“…After 7 days, the explanted material indicated significant cell infiltration and lower bacterial infection. 115 Acetylsalicylic acid (ASA) is another antiplatelet agent which was printed together with high (50 000 g/mol) and low (550 g/mol) molecular weight PCL matrices forming small diameter vascular grafts. The grafts showed a reduced platelet adhesion and provided a sustained release of ASA for 2 weeks by diffusion and matrix degradation.…”

Section: Implantable Controlled Release Systemsmentioning

confidence: 99%

“…aureus suspension (10 8 CFU/mL) and subcutaneously implanted in rabbits. After 7 days, the explanted material indicated significant cell infiltration and lower bacterial infection …”

Section: Implantable Controlled Release Systemsmentioning

confidence: 99%

Incorporation of Controlled Release Systems Improves the Functionality of Biodegradable 3D Printed Cardiovascular Implants

Kabirian,

Mozafari,

Mela

et al. 2023

ACS Biomater. Sci. Eng.

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New horizons in cardiovascular research are opened by using 3D printing for biodegradable implants. This additive manufacturing approach allows the design and fabrication of complex structures according to the patient’s imaging data in an accurate, reproducible, cost-effective, and quick manner. Acellular cardiovascular implants produced from biodegradable materials have the potential to provide enough support for in situ tissue regeneration while gradually being replaced by neo-autologous tissue. Subsequently, they have the potential to prevent long-term complications. In this Review, we discuss the current status of 3D printing applications in the development of biodegradable cardiovascular implants with a focus on design, biomaterial selection, fabrication methods, and advantages of implantable controlled release systems. Moreover, we delve into the intricate challenges that accompany the clinical translation of these groundbreaking innovations, presenting a glimpse of potential solutions poised to enable the realization of these technologies in the realm of cardiovascular medicine.

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