3D Shape Analysis of the Supraspinatus Muscle

Ward, Aaron D.; Hamarneh, Ghassan; Ashry, Reem; Schweitzer, Mark E.

doi:10.1016/j.acra.2007.06.014

Cited by 15 publications

(2 citation statements)

References 17 publications

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“…In order to reliably measure valve shape and size, we utilized AMIRA software to assemble a complete series of adjacent histological sections in both coronal and transverse orientations into 3-dimensional (3D) valve models. Using surface area to volume (SA:Vol) ratios as a measure of shape and size [ 44 ], we quantified the difference between Pdlim7 -/- and WT valve leaflets. We determined that Pdlim7 -/- mice have increased SA:Vol ratios for both the mitral (n=5; 1.015 0.157) and tricuspid (n=4; 0.917 0.111) valves in comparison to WT ( Figure 4G-I and Video S1 ; n=6, 0.809 0.043, p=0.0127 and n=5, 0.782 0.038, p=0.0363, respectively).…”

Section: Resultsmentioning

confidence: 99%

Loss of the Cytoskeletal Protein Pdlim7 Predisposes Mice to Heart Defects and Hemostatic Dysfunction

et al. 2013

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The actin-associated protein Pdlim7 is essential for heart and fin development in zebrafish; however, the expression and function of this PDZ-LIM family member in the mammal has remained unclear. Here, we show that Pdlim7 predominantly localizes to actin-rich structures in mice including the heart, vascular smooth muscle, and platelets. To test the requirement for Pdlim7 in mammalian development and function, we analyzed a mouse strain with global genetic inactivation of Pdlim7. We demonstrate that Pdlim7 loss-of-function leads to significant postnatal mortality. Inactivation of Pdlim7 does not disrupt cardiac development, but causes mild cardiac dysfunction in adult mice. Adult Pdlim7 -/- mice displayed increased mitral and tricuspid valve annulus to body weight ratios. These structural aberrations in Pdlim7 -/- mice were supported by three-dimensional reconstructions of adult cardiac valves, which revealed increased surface area to volume ratios for the mitral and tricuspid valve leaflets. Unexpectedly, we found that loss of Pdlim7 triggers systemic venous and arterial thrombosis, leading to significant mortality shortly after birth in Pdlim7 +/- (11/60) and Pdlim7 -/- (19/35) mice. In line with a prothrombotic phenotype, adult Pdlim7 -/- mice exhibit dramatically decreased tail bleed times compared to controls. These findings reveal a novel and unexpected function for Pdlim7 in maintaining proper hemostasis in neonatal and adult mice.

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Section: Resultsmentioning

confidence: 99%

Loss of the Cytoskeletal Protein Pdlim7 Predisposes Mice to Heart Defects and Hemostatic Dysfunction

et al. 2013

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“…Thus, 3 principal directions corresponding to object length, width and height, respectively, were calculated by principal component analysis for the surface points of the object. 28 FWHM sizes along the 3 principal directions were determined by measuring the distance between the surface points along these directions.…”

Section: Methodsmentioning

confidence: 99%

Kidney Stone Volume Estimation from Computerized Tomography Images Using a Model Based Method of Correcting for the Point Spread Function

Duan

Wang

et al. 2012

Journal of Urology

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Purpose We propose a method to improve the accuracy of volume estimation of kidney stones from computerized tomography images. Materials and Methods The proposed method consisted of 2 steps. A threshold equal to the average of the computerized tomography number of the object and the background was first applied to determine full width at half maximum volume. Correction factors were then applied, which were precalculated based on a model of a sphere and a 3-dimensional Gaussian point spread function. The point spread function was measured in a computerized tomography scanner to represent the response of the scanner to a point-like object. Method accuracy was validated using 6 small cylindrical phantoms with 2 volumes of 21.87 and 99.9 mm3, and 3 attenuations, respectively, and 76 kidney stones with a volume range of 6.3 to 317.4 mm3. Volumes estimated by the proposed method were compared with full width at half maximum volumes. Results The proposed method was significantly more accurate than full width at half maximum volume (p <0.0001). The magnitude of improvement depended on stone volume with smaller stones benefiting more from the method. For kidney stones 10 to 20 mm3 in volume the average improvement in accuracy was the greatest at 19.6%. Conclusions The proposed method achieved significantly improved accuracy compared with threshold methods. This may lead to more accurate stone management.

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Segmentation of shoulder muscle MRI using a new Region and Edge based Deep Auto-Encoder

Khan

Lee

et al. 2022

Multimed Tools Appl

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3D Shape Analysis of the Supraspinatus Muscle

Cited by 15 publications

References 17 publications

Loss of the Cytoskeletal Protein Pdlim7 Predisposes Mice to Heart Defects and Hemostatic Dysfunction

Loss of the Cytoskeletal Protein Pdlim7 Predisposes Mice to Heart Defects and Hemostatic Dysfunction

Kidney Stone Volume Estimation from Computerized Tomography Images Using a Model Based Method of Correcting for the Point Spread Function

Segmentation of shoulder muscle MRI using a new Region and Edge based Deep Auto-Encoder

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