3D T1 relaxometry pre and post gadoxetic acid injection for the assessment of liver cirrhosis and liver function

Besa, Cecilia; Bane, Octavia; Jajamovich, Guido H.; Marchione, Joseph; Taouli, Bachir

doi:10.1016/j.mri.2015.06.013

Cited by 42 publications

(33 citation statements)

References 35 publications

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“…17 Several studies have examined whether the uptake of a liver-specific contrast agent in the liver parenchyma is correlated with liver function and the degree of liver fibrosis, yet only a few have used histopathology data as the reference standard. 40 We did not perform T 1 measurements in this study. Another study by Verloh et al 36 showed significant differences between the relative liver enhancement and the degree of liver fibrosis, with AUCs of 0.98 and 0.96 for advanced liver fibrosis and cirrhosis, respectively.…”

Section: Discussionmentioning

confidence: 97%

Detection of liver fibrosis using qualitative and quantitative MR elastography compared to liver surface nodularity measurement, gadoxetic acid uptake, and serum markers

Besa

Wagner

et al. 2017

Magnetic Resonance Imaging

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Section: Discussionmentioning

confidence: 97%

Detection of liver fibrosis using qualitative and quantitative MR elastography compared to liver surface nodularity measurement, gadoxetic acid uptake, and serum markers

Besa

Wagner

et al. 2017

Magnetic Resonance Imaging

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“…This is caused by either reduced hepatic uptake associated with decreased expression of the hepatic organic anion transporters due to either decrease in normal hepatocytes or hepatocyte dysfunction, degeneration or necrosis and/or prolongation of liver enhancement due to decreased biliary excretion with increasing hepatic fibrosis [131,141]. Hepatic uptake of gadoxetate disodium is dependent on specific cellular transporters (OATP receptors).…”

Section: Mri With Hepatobiliary Contrast Agentsmentioning

confidence: 99%

Evaluation of hepatic fibrosis: a review from the society of abdominal radiology disease focus panel

et al. 2017

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Hepatic fibrosis is potentially reversible, however early diagnosis is necessary for treatment in order to halt progression to cirrhosis and development of complications including portal hypertension and hepatocellular carcinoma. Morphologic signs of cirrhosis on ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI) alone are unreliable and are seen with more advanced disease. Newer imaging techniques to diagnose liver fibrosis are reliable and accurate, and include magnetic resonance elastography and US elastography (1 dimensional transient elastography and point shear wave elastography or acoustic radiation force impulse imaging). Research is ongoing with multiple other techniques for the noninvasive diagnosis of hepatic fibrosis, including MRI with diffusion weighted imaging, hepatobiliary contrast enhancement, and perfusion; CT using perfusion, fractional extracellular space techniques, and dual energy, contrast-enhanced US, texture analysis in multiple modalities, quantitative mapping, and direct molecular imaging probes. Efforts to advance the noninvasive imaging assessment of hepatic fibrosis will facilitate earlier diagnosis and improved patient monitoring with the goal of preventing the progression to cirrhosis and its complications.

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“…It is a more reliable and accurate method to directly measure T 1 relaxation time of the target organ, 40 T 1 mapping sequences have been developed and applied to clinical routine assessment of healthy individuals and different diseases, including a number of cardiac conditions, such as myocardial fibrosis and myocardial deposition, 41 liver cirrhosis, 42 and pancreatitis. 43,44 The T 1 mapping technique used in this study for the prediction of pancreatitis that presented a better discrimination compared with the conventional T 1 WI techniques.…”

Section: Discussionmentioning

confidence: 99%

Mannose-coated gadolinium liposomes for improved magnetic resonance imaging in acute pancreatitis

Tian¹,

Liu²,

Chen³

et al. 2017

IJN

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Background Acute pancreatitis (AP) is an acute inflammatory condition of the pancreas. The symptoms, treatment, and prognosis of mild and severe AP are different, and severe AP is a potentially life-threatening disease with a high incidence of complications and high mortality rate. Thus, it is urgent to develop an effective approach to reliably discriminate between mild and severe AP. Methods We have developed novel gadolinium-diethylenetriaminepentaacetic (Gd-DTPA)-loaded mannosylated liposomes (named thereafter M-Gd-NL) that preferably target macrophages in AP. The targeting ability of M-Gd-NL toward macrophages in AP and its ability to discriminate between mild and severe AP were evaluated. Results The liposomes were of desired particle size (~100 nm), Gd-DTPA encapsulation efficiency (~85%), and stability. M-Gd-NL and non-targeted Gd-DTPA-loaded liposomes (Gd-NL) exhibited increased relaxivity compared with Gd-DTPA. Compared with Gd-NL and Gd-DTPA, M-Gd-NL showed increased uptake in macrophages, resulting in increased T 1 imaging ability both in vitro (macrophage cell line) and in vivo (severe AP model). Importantly, M-Gd-NL had the ability to discriminate between mild and severe AP, as reflected by a significantly higher T 1 magnetic resonance imaging signal in severe AP than in mild AP. M-Gd-NL did not show severe organ toxicity in rats. Conclusion Our data suggest that M-Gd-NL had enhanced magnetic resonance imaging ability by targeting macrophages in AP and good ability to discriminate between mild and severe AP. We believe that M-Gd-NL could shed new light on the diagnosis of AP in the near future.

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3D T1 relaxometry pre and post gadoxetic acid injection for the assessment of liver cirrhosis and liver function

Cited by 42 publications

References 35 publications

Detection of liver fibrosis using qualitative and quantitative MR elastography compared to liver surface nodularity measurement, gadoxetic acid uptake, and serum markers

Detection of liver fibrosis using qualitative and quantitative MR elastography compared to liver surface nodularity measurement, gadoxetic acid uptake, and serum markers

Evaluation of hepatic fibrosis: a review from the society of abdominal radiology disease focus panel

Mannose-coated gadolinium liposomes for improved magnetic resonance imaging in acute pancreatitis

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