3D Tissue Engineered Supramolecular Hydrogels for Controlled Chondrogenesis of Human Mesenchymal Stem Cells

Jung, Hyuntae; Park, Ji Sun; Yeom, Junseok; Selvapalam, Narayanan; Park, Kyeng Min; Oh, Kyunghoon; Yang, Jeong-A; Park, Keun Hong; Hahn, Sei Kwang; Kim, Kimoon

doi:10.1021/bm401123m

Cited by 105 publications

(128 citation statements)

References 24 publications

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“…However, dual combinations of these GFs show a synergic effect, being possible to simultaneously induce migration and collagen deposition when using VEGF and BMP-2, and observing a greatest influence on tissue deposition when combining TGF-3 and BMP-2 (113,114) . Furthermore, engineered hydrogels can be used to stimulate cartilage regeneration (115) . Considering that…”

Section: Developing Functional Drug-releasing Biomaterialsmentioning

confidence: 99%

“…MSCs are a promising source for cartilage regeneration and that TGF- family has a key role in the chondrogenesis process of MSCs, Jung and collaborators have designed Cyclodextrin(CD)-and Cucurbituril(CB)-based hydrogels able to deliver TGF- through a spatiotemporal control in vivo, showing again promising results (115) .…”

Section: Developing Functional Drug-releasing Biomaterialsmentioning

confidence: 99%

“…Increased the formation of new bone in the porosities of a canine implant (151) TGF- Cyclodextrin(CD)-and Cucurbituril(CB)-based hydrogels Effective chondrogenic differentiation (115) VEGF PEG-based hydrogels Stimulates cell migration and proliferation and maintain cell viability (116,117) VEGF Embedded in gelatine-like gels…”

Section: Hydrogels For Nerve Tissue Regenerationmentioning

confidence: 99%

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Integrating Mechanical and Biological Control of Cell Proliferation Through Bioinspired Multieffector Materials

Seras‐Franzoso

Tatkiewicz

Vázquez

et al. 2015

Nanomedicine (Lond.)

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In nature, cells respond to complex mechanical and biological stimuli whose understanding is required for tissue construction in regenerative medicine. However, the full replication of such bimodal effector networks is far to be reached. Engineering substrate roughness and architecture allows regulating cell adhesion, positioning, proliferation, differentiation and survival, and the external supply of soluble protein factors (mainly growth factors and hormones) has been long applied to promote growth and differentiation. Further, bio-inspired scaffolds are progressively engineered as reservoirs for the in situ sustained release of soluble protein factors from functional topographies. We review here how research progresses towards the design of integrative, holistic scaffold platforms based on the exploration of individual mechanical and biological effectors and their further combination.

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Section: Developing Functional Drug-releasing Biomaterialsmentioning

confidence: 99%

Section: Developing Functional Drug-releasing Biomaterialsmentioning

confidence: 99%

Section: Hydrogels For Nerve Tissue Regenerationmentioning

confidence: 99%

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Integrating Mechanical and Biological Control of Cell Proliferation Through Bioinspired Multieffector Materials

Seras‐Franzoso

Tatkiewicz

Vázquez

et al. 2015

Nanomedicine (Lond.)

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“…[1][2][3] Their anchoring onto macromolecules offers further opportunities to expand their applications, [8][9][10] however there are currently few examples of such reports. [11][12][13][14][15][16] The relatively few reports are likely as a result of the difficulties encountered in the modification of CBs; this problem persisted until Kim's group reported the functionalization of CBs with a facile oxidation method in 2003. 17 Through oxidization of CBs with persulfate, hydroxyl groups -which are suitable for further functionalization-could be introduced at their peripheries.…”

Section: -7mentioning

confidence: 99%

“…[11][12][13] The eminent binding properties of CB[6] allow these polymer nanocapsules to be decorated easily with targeting and labeling groups through host-guest interactions. Recently, allyl functionalized CB[6] and CB [7] were grafted on to hyaluronate through a thiol-ene click reaction, [14][15][16] and where employed for theranostic systems and tissue engineering applications. In addition of the oxidation method, Isaacs's group developed a different method to synthesize CB derivatives.…”

mentioning

confidence: 99%

Synthesis of linear cucurbit[7]uril pendent copolymers through radical polymerization: Polymers with ultra‐high binding affinity

Chen

Tan

2015

J. Polym. Sci. Part A: Polym. Chem.

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Cucurbiturils (CBs) are a family of macrocyclic molecules with high binding affinity and high binding selectivity. [1][2][3][4][5][6][7] They have been intensively researched for the past decade and have applications in a wide range of fields including molecular recognition, catalysis, drug delivery, bioassays, nanoparticle synthesis and modification, and molecular devices.1-3 Their anchoring onto macromolecules offers further opportunities to expand their applications, [8][9][10] however there are currently few examples of such reports.11-16 The relatively few reports are likely as a result of the difficulties encountered in the modification of CBs; this problem persisted until Kim's group reported the functionalization of CBs with a facile oxidation method in 2003.17 Through oxidization of CBs with persulfate, hydroxyl groups -which are suitable for further functionalization-could be introduced at their peripheries. Following that a series of polymer nanocapsules constructed with perallyloxy-CB[6] and dithiols have been reported. [11][12][13] The eminent binding properties of CB[6] allow these polymer nanocapsules to be decorated easily with targeting and labeling groups through host-guest interactions. Recently, allyl functionalized CB[6] and CB [7] were grafted on to hyaluronate through a thiol-ene click reaction, [14][15][16] and where employed for theranostic systems and tissue engineering applications. In addition of the oxidation method, Isaacs's group developed a different method to synthesize CB derivatives. In their works, CB [6] and CB [7] derivatives were synthesized by the condensation glycoluril hexamer with phthalaldehydes and glycoluril bis(cyclic ethers), respectively.18-20 Despite these, there is still an unmet need for new and facile methods for the construction of CB covalently linked polymers to broaden their portfolio of potential applications.The binding properties of the covalently linked macrocycle polymers are one of the key considerations in their design for specific applications. 21,22 Although their binding properties are usually determined by the binding properties of the macrocycle moieties; the structure of polymers also has a profound and sophisticated effect. Based on the research on polymeric cyclodextrins (CDs), if the CD moieties are spatially isolated, their binding affinity to guest molecules decreases slightly; 23-25 while if they are in close proximity, adjacent two CD moieties may have a cooperation effect and both the binding affinity and binding stoichiometry will be affected. [24][25][26][27][28] To the best of our knowledge, there have been no studies on the binding property of polymeric CBs prior to this work. Here, we present a universal method for the synthesis of linear CB [7] pendent copolymers through free radical polymerization (Scheme 1). The binding properties of the obtained copolymers were studied using turbidity measurement, isothermal titration calorimetry (ITC) and NMR.Free radical polymerization is a universal polymerization method which is suitable f...

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Robust Host–Guest Chemistry of Cucurbit[ n ]uril

Kim

Shetty

Park

2016

Macrocyclic and Supramolecular Chemistry

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3D Tissue Engineered Supramolecular Hydrogels for Controlled Chondrogenesis of Human Mesenchymal Stem Cells

Cited by 105 publications

References 24 publications

Integrating Mechanical and Biological Control of Cell Proliferation Through Bioinspired Multieffector Materials

Integrating Mechanical and Biological Control of Cell Proliferation Through Bioinspired Multieffector Materials

Synthesis of linear cucurbit[7]uril pendent copolymers through radical polymerization: Polymers with ultra‐high binding affinity

Robust Host–Guest Chemistry of Cucurbit[ n ]uril

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