3D X-ray micro-computed tomography imaging for the microarchitecture evaluation of porous metallic implants and scaffolds

Liu, Yuchuan; Dong-yang, Xie; Zhou, Rifeng; Zhang, Yuxin

doi:10.1016/j.micron.2020.102994

Cited by 19 publications

(17 citation statements)

References 70 publications

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“…The X-rays penetrate the rotating sample and 2D projections of different angular positions can be obtained. Subsequently, 3D micro-CT image reconstruction is possible by means of processing software, for example, by using the Feldkamp–Davis–Kress (FDK) algorithm [ 129 , 130 ]. This has been proven useful in gaining insight into the morphology of bioactive coatings, usually focusing on the determination of porosity [ 131 , 132 ].…”

Section: Interaction and Morphology Studiesmentioning

confidence: 99%

Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants

Kravanja

Finšgar

2021

Biomedicines

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The development of bioactive coatings for orthopedic implants has been of great interest in recent years in order to achieve both early- and long-term osseointegration. Numerous bioactive materials have been investigated for this purpose, along with loading coatings with therapeutic agents (active compounds) that are released into the surrounding media in a controlled manner after surgery. This review initially focuses on the importance and usefulness of characterization techniques for bioactive coatings, allowing the detailed evaluation of coating properties and further improvements. Various advanced analytical techniques that have been used to characterize the structure, interactions, and morphology of the designed bioactive coatings are comprehensively described by means of time-of-flight secondary ion mass spectrometry (ToF-SIMS), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), scanning electron microscopy (SEM), transmission electron microscopy (TEM), 3D tomography, quartz crystal microbalance (QCM), coating adhesion, and contact angle (CA) measurements. Secondly, the design of controlled-release systems, the determination of drug release kinetics, and recent advances in drug release from bioactive coatings are addressed as the evaluation thereof is crucial for improving the synthesis parameters in designing optimal bioactive coatings.

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Section: Interaction and Morphology Studiesmentioning

confidence: 99%

Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants

Kravanja

Finšgar

2021

Biomedicines

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“…Recent studies have demonstrated the excellent reproducibility and accuracy of micro-CT measurements of bone morphology ( Bouxsein et al, 2010 ; Liu et al, 2021 ). Therefore, 3D micro-CT analysis was performed to investigate bone regeneration under bacterial infection conditions ( Figure 8D ).…”

Section: Resultsmentioning

confidence: 99%

Controllable AgNPs encapsulation to construct biocompatible and antibacterial titanium implant

Wei

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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Silver nanoparticles (AgNPs) are progressively becoming an in-demand material for both medical and life use due to their effective antimicrobial properties. The high surface area-to-volume ratio endows AgNPs with enhanced antibacterial capacity accompanied by inevitable cytotoxicity. Surface coating technique could precisely regulate the particle shape, aggregation, and Ag+ release pattern of AgNPs, by which the cytotoxicity could be significantly reduced. Various coating methods have been explored to shell AgNPs, but it remains a great challenge to precisely control the aggregation state of AgNPs and their shell thickness. Herein, we proposed a simple method to prepare a tunable polydopamine (pDA) coating shell on AgNPs just by tuning the reaction pH and temperature, yet we obtained high antibacterial property and excellent biocompatibility. SEM and TEM revealed that pDA coated AgNPs can form core-shell structures with different aggregation states and shell thickness. Both in vitro and in vivo antibacterial tests show that acid condition and heat-treatment lead to appropriate AgNPs cores and pDA shell structures, which endow Ti with sustained antibacterial properties and preferable cell compatibility. One month of implantation in an infected animal model demonstrated that the obtained surface could promote osteogenesis and inhibit inflammation due to its strong antibacterial properties. Therefore, this study provides a promising approach to fabricate biocompatible antibacterial surface.

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“…This allows the feasible analysis of bone tissue 3D parameters (e.g., bone volume (BV), bone volume ratio (BV/TV)), and 2D parameters (e.g., bone surface (BS)). In addition, information on the interaction between the implant and the bone tissue (e.g., bone-to-implant contact (BIC)), can also be estimated given proper data processing to minimize titanium-dependent imaging artifacts [ 40 ].…”

Section: Resultsmentioning

confidence: 99%

Hydrothermal Synthesis of Fluorapatite Coatings over Titanium Implants for Enhanced Osseointegration—An In Vivo Study in the Rabbit

Santiago

Martín

Colaço

et al. 2022

JFB

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This work aims at the development and characterization of fluorapatite coatings, innovatively prepared by the hydrothermal method, aiming for enhanced osseointegration of titanium implants. Fluoride-containing coatings were prepared and characterized by scanning and transmission electron microscopy, Fourier-transform infrared spectroscopy—attenuated total reflectance, and X-ray photoelectron spectroscopy. The biological response was characterized by microtomographic evaluation and histomorphometric analysis upon orthotopic implantation in a translational rabbit experimental model. Physic-chemical analysis revealed the inclusion of fluoride in the apatite lattice with fluorapatite formation, associated with the presence of citrate species. The in vivo biological assessment of coated implants revealed an enhanced bone formation process—with increased bone-to-implant contact and bone volume. The attained enhancement of the osteogenic process may be attributable to the conjoined modulatory activity of selected fluoride and citrate levels within the produced coatings. In this regard, the production of fluorapatite coatings with citrate, through the hydrothermal method, entails a promising approach for enhanced osseointegration in implant dentistry and orthopedic applications.

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3D X-ray micro-computed tomography imaging for the microarchitecture evaluation of porous metallic implants and scaffolds

Cited by 19 publications

References 70 publications

Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants

Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants

Controllable AgNPs encapsulation to construct biocompatible and antibacterial titanium implant

Hydrothermal Synthesis of Fluorapatite Coatings over Titanium Implants for Enhanced Osseointegration—An In Vivo Study in the Rabbit

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