4:21 PM Abstract No. 190 Quantitative 4D digital subtraction angiography: a novel technique for quantifying changes in hepatic arterial flow during transarterial embolization

Harari, Colin; Meram, Ece; Shaughnessy, Gabe; Wagner, Martin; Mistretta, Charles; Laeseke, Paul F.

doi:10.1016/j.jvir.2018.01.213

Cited by 2 publications

(3 citation statements)

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“…Quantitative DSA (qDSA) 9,10 and 4D DSA [11][12][13][14][15][16] have previously been proposed as noninvasive methods to determine blood velocity and flow intraprocedurally. Both methods rely on contrast-enhanced image sequences, where information on blood velocity can be inferred by tracking the movement of contrast agent in the vessels of interest.…”

Section: Introductionmentioning

confidence: 99%

Spatiotemporal frequency domain analysis for blood velocity measurement during embolization procedures

Wagner,

Whitehead,

Periyasamy

et al. 2023

Medical Physics

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BackgroundCurrently, determining procedural endpoints and treatment efficacy of vascular interventions is largely qualitative and relies on subjective visual assessment of digital subtraction angiography (DSA) images leading to large interobserver variabilities and poor reproducibility. Quantitative metrics such as the residual blood velocity in embolized vessel branches could help establish objective and reproducible endpoints. Recently, velocity quantification techniques based on a contrast enhanced X‐ray sequence such as qDSA and 4D DSA have been proposed. These techniques must be robust, and, to avoid radiation dose concerns, they should be compatible with low dose per frame image acquisition.PurposeTo develop and evaluate a technique for robust blood velocity quantification from low dose contrast enhanced X‐ray image sequences that leverages the oscillating signal created by pulsatile blood flow.MethodsThe proposed spatiotemporal frequency domain (STF) approach quantifies velocities from time attenuation maps (TAMs) representing the oscillating signal over time for all points along a vessel centerline. Due to the time it takes a contrast bolus to travel along the vessel centerline, the resulting TAM resembles a sheared sine wave. The shear angle is related to the velocity and can be determined in the spatiotemporal frequency domain after applying the 2D Fourier transform to the TAM. The approach was evaluated in a straight tube phantom using three different radiation dose levels and compared to ultrasound transit‐time‐based measurements. The STF velocity results were also compared to previously published approaches for the measurement of blood velocity from contrast enhanced X‐ray sequences including shifted least squared (SLS) and phase shift (PHS). Additionally, an in vivo porcine study (n = 8) was performed where increasing amounts of embolic particles were injected into a hepatic or splenic artery with intermittent velocity measurements after each injection to monitor the resulting reduction in velocity.ResultsAt the lowest evaluated dose level (average air kerma rate 1.3 mGy/s at the interventional reference point), the Pearson correlation between ultrasound and STF velocity measurements was 99%. This was significantly higher () than corresponding correlation results between ultrasound and the previously published SLS and PHS approaches (91 and 93%, respectively). In the in vivo study, a reduction in velocity was observed in 85.7% of cases after injection of 1 mL, 96.4% after 3 mL, and 100.0% after 4 mL of embolic particles.ConclusionsThe results show good agreement of the spatiotemporal frequency domain approach with ultrasound even in low dose per frame image sequences. Additionally, the in vivo study demonstrates the ability to monitor the physiological changes due to embolization. This could provide quantitative metrics during vascular procedures to establish objective and reproducible endpoints.

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Section: Introductionmentioning

confidence: 99%

Spatiotemporal frequency domain analysis for blood velocity measurement during embolization procedures

Wagner,

Whitehead,

Periyasamy

et al. 2023

Medical Physics

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“…10,11,12 In preliminary studies, we have shown that, through use of a Fourier Phase technique, it is possible to obtain values of blood velocity using 4D-DSA data that are in agreement with data obtained using a doppler flow wire. 13 In this report we describe and illustrate further development and testing of this approach. Our ultimate aim is to provide a robust automated algorithm that will use the spatial and temporal data from a 4D-DSA to provide clinicians with a color-coded display of blood flow and velocity in a vascular territory of interest.…”

Section: Introductionmentioning

confidence: 99%

“…In preliminary studies, we have shown that, through use of a Fourier Phase technique, it is possible to obtain values of blood velocity using 4D‐DSA data that are in agreement with data obtained using a doppler flow wire . In this report we describe and illustrate further development and testing of this approach.…”

Section: Introductionmentioning

confidence: 99%

Measuring blood velocity using 4D‐DSA: A feasibility study

et al. 2018

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4D-DSA provides temporal and spatial information about blood flow and vascular geometry. This information is obtained using conventional rotational angiographic systems. In this small feasibility study, these data allowed calculations of velocity values that correlated well with measured values. The availability of velocity and blood flow information in the interventional setting would support a more quantitative approach to diagnosis, treatment planning and post-treatment evaluations of a variety of cerebrovascular diseases.

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4:21 PM Abstract No. 190 Quantitative 4D digital subtraction angiography: a novel technique for quantifying changes in hepatic arterial flow during transarterial embolization

Cited by 2 publications

References 0 publications

Spatiotemporal frequency domain analysis for blood velocity measurement during embolization procedures

Spatiotemporal frequency domain analysis for blood velocity measurement during embolization procedures

Measuring blood velocity using 4D‐DSA: A feasibility study

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