4-Carboxyanilinium hydrogensulfate

Abstract

The cohesion in the title structure (p‐CPABS), C7H8NO2+·HSO4−, is assured by an intricate three‐dimensional hydrogen‐bonded network of types N—H...O and O—H...O involving anions, carboxyl and amino groups in addition to the ionic interactions.

A new pharmaceutical co-crystal: (S)-naproxen-isonocotinamide

“…(2011) Hydrogen bonding is one of the most versatile noncovalent forces in supramolecular chemistry and crystal engineering [1]. Therefore, in the past decades assessment of discrete hydrogen bonding patterns had received great attention [2] because of its widespread occurrence in biological systems.…”

“…In the new co-crystal structure the homosynthon amide•••amide between two isonicotinamide molecules is retained, as in isonicotinamide polymorph I [2], and acid•••N aromatic and amide•••acid heterosynthons link naproxen to isonicotinamide. Hybrid materials including dihydrogenmonophosphate and bisulfate anions have received increasing attention [1,2] owing to their interesting ferroelastic [3], NLO [4], phase transitions properties [5] and their potential application in pharmaceutical industry [6].…”

“…The structure of form B consists of head-to-tail dimers also linked by N-HN HB. [1] Irbesartan has been studied by solid state NMR at RT and at 253K; [2] the authors easily distinguished the two modifications by 13 C CP/MAS. They also carried out 15 N CP/MAS studies and concluded that, in contrast to form A in which the 6 expected signals of the 6 molecular nitrogens are found at RT, only two sharp peaks appeared in the spectrum of form B at the same temperature (with a broad resonance region) and the 6 expected signal were only recovered at 253K for this modification.…”

“…Hybrid materials including dihydrogenmonophosphate and bisulfate anions have received increasing attention [1,2] owing to their interesting ferroelastic [3], NLO [4], phase transitions properties [5] and their potential application in pharmaceutical industry [6].…”

“…Many inorganic cytosinium salts have been previously synthesized: chloride [2], nitrate [3] and dihydrogenphosphate [4,5].…”