4-Hydroxynonenal Promotes Growth and Angiogenesis of Breast Cancer Cells through HIF-1α Stabilization

Li, Yaoping; Tian, Fei; Shi, Pengcheng; Guo, Ling‐Yun; H, Wu; Chen, Run-Qi; Xue, Jin-Ming

doi:10.7314/apjcp.2014.15.23.10151

Cited by 31 publications

(25 citation statements)

References 34 publications

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“…HNE treatment of MG63 human osteosarcoma cells could activate caspase-3 and altered the Bax/Bcl-2 ratio, thereby inducing cell death [111]. A recent research showed that HNE increased the growth of breast cancer cells and promoted their angiogenesis and invasion [112]. Elevated levels of MDA were observed in plasma and blood serum of patients with breast, lung, ovarian, thyroid, and oral cancer, and precancer states [113–122].…”

Section: Poducts Of Lipid Peroxidation As Common Markers Of Oxidativementioning

confidence: 99%

Mitochondrial dysfunction and oxidative stress in aging and cancer

et al. 2016

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Aging and cancer are the most important issues to research. The population in the world is growing older, and the incidence of cancer increases with age. There is no doubt about the linkage between aging and cancer. However, the molecular mechanisms underlying this association are still unknown. Several lines of evidence suggest that the oxidative stress as a cause and/or consequence of the mitochondrial dysfunction is one of the main drivers of these processes. Increasing ROS levels and products of the oxidative stress, which occur in aging and age-related disorders, were also found in cancer. This review focuses on the similarities between ageing-associated and cancer-associated oxidative stress and mitochondrial dysfunction as their common phenotype.

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Section: Poducts Of Lipid Peroxidation As Common Markers Of Oxidativementioning

confidence: 99%

Mitochondrial dysfunction and oxidative stress in aging and cancer

et al. 2016

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“…Another study revealed that the expression of sirtuin-3 (SIRT3), a mitochondria-localized tumor suppressor, was decreased in breast tumors relative to normal type-matched tissue. SIRT3 induced destabilization of hypoxia-inducible factor-1α, whereas knockdown of SIRT3 increased cancer cell growth and angiogenesis (36). The SIRT3 gene also exhibited lower expression in various tumor types, including clear cell hepatocellular, head and neck squamous cell, glioblastoma multiforme, testicular and prostate cancers (37).…”

Section: Introductionmentioning

confidence: 99%

Voltage-gated calcium channels: Novel targets for cancer therapy

et al. 2017

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Voltage-gated calcium channels (VGCCs) comprise five subtypes: The L-type; R-type; N-type; P/Q-type; and T-type, which are encoded by α1 subunit genes. Calcium ion channels also have confirmed roles in cellular functions, including mitogenesis, proliferation, differentiation, apoptosis and metastasis. An association between VGCCs, a reduction in proliferation and an increase in apoptosis in prostate cancer cells has also been reported. Therefore, in the present study, the online clinical database Oncomine was used to identify the alterations in the mRNA expression level of VGCCs in 19 cancer subtypes. Overall, VGCC family genes exhibited under-expression in numerous types of cancer, including brain, breast, kidney and lung cancers. Notably, the majority of VGCC family members (CACNA1C, CACNA1D, CACNA1A, CACNA1B, CACNA1E, CACNA1H and CACNA1I) exhibited low expression in brain tumors, with mRNA expression levels in the top 1–9% of downregulated gene rankings. A total of 5 VGCC family members (CACNA1A, CACNA1B, CACNA1E, CACNA1G and CACNA1I) were under-expressed in breast cancer, with a gene ranking in the top 1–10% of the low-expressed genes compared with normal tissue. In kidney and lung cancers, CACNA1S, CACNA1C, CACNA1D, CACNA1A and CACNA1H exhibited low expression, with gene rankings in the top 1–8% of downregulated genes. In conclusion, the present findings may contribute to the development of new cancer treatment approaches by identifying target genes involved in specific types of cancer.

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“…Trastuzumab is a monoclonal antibody against the HER2 domain, one of the most commonly used drugs for the treatment of HER2+ breast cancers. The induction of resistance to Trastuzumab in breast cancer cells through the activation of the signal transducer and activator of transcription protein (STAT3) pathway/HIF-1α/ hairy and enhancer of split-1 (Hes-1) leading to a down-regulation of phosphatase and tensin homolog (PTEN) was evaluated [32] . Knockdown of HIF-1α in Trastuzumab-resistant cells was observed to cause a decrease in the proliferation of HIF-1α, just as the up-expression of HIF-1α in cells caused resistance to the anti-proliferative effect of Trastuzumab, showing that there is a direct link between the levels of HIF-1αexpression and resistance to Trastuzumab.…”

Section: Hif-1α In Drug Resistencementioning

confidence: 99%

“…Knockdown of HIF-1α in Trastuzumab-resistant cells was observed to cause a decrease in the proliferation of HIF-1α, just as the up-expression of HIF-1α in cells caused resistance to the anti-proliferative effect of Trastuzumab, showing that there is a direct link between the levels of HIF-1αexpression and resistance to Trastuzumab. HIF-1α up-regulates HES-1 expression, a negative regulator of the PTEN promoter, implying that HIF-1α can modulate PTEN expression in Trastuzumab-resistant cells with the constitutive activation of the STAT3 protein [32] . 4-Hydroxynonenal (4-HNE) is produced in the lipid peroxidation of cells and is present at high levels in invasive breast cancer cells.…”

Section: Hif-1α In Drug Resistencementioning

confidence: 99%

The role of hypoxia-induced factor 1�� in breast cancer

Peiró¹,

Encina²,

Perez³

et al. 2019

JCMT

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Breast cancer usually grows very quickly, becoming insensitive to blood flow in nearby veins; because of that, inside solid tumors it's possible to find a hypoxic environment, in other words, an environment where oxygen is less available. Another feature of cancer is its angiogenesis rate, because of the high energy demand, new blood vessels must be produced to take nutrients inside the solid tumor mass. Even with normal blood flow bringing the cancer oxygen and nutrients, its cells favor hypoxia, in an event known as Warburg Effect. According to the Warburg Effect, cells, even with normal oxygen rates, prefer to use fermentation instead of the citric acid cycle to produce ATP. For the cancer to operate normally in hypoxia, a transcription factor family is activated, known as hypoxia-induced factors (HIF), composed of a HIF-1β and a HIF-1α subunits. As HIF-1α is expressed during hypoxia, it is a great target for treatments and a breast cancer biomarker. Because of the role of HIF-1α in cancer and the high incidence of breast cancer worlwide, this review was performed in order to bring the most recent results concerning the role HIF-1α can exert in breast cancer development and progression.

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4-Hydroxynonenal Promotes Growth and Angiogenesis of Breast Cancer Cells through HIF-1α Stabilization

Cited by 31 publications

References 34 publications

Mitochondrial dysfunction and oxidative stress in aging and cancer

Mitochondrial dysfunction and oxidative stress in aging and cancer

Voltage-gated calcium channels: Novel targets for cancer therapy

The role of hypoxia-induced factor 1�� in breast cancer

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