2018
DOI: 10.1177/0960327118758365
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4-Methylcatechol stimulates apoptosis and reduces insulin secretion by decreasing betacellulin and inhibin beta-A in INS-1 beta-cells

Abstract: Insulinoma INS-1 cell line is a pancreatic beta cell tumor which is characterized with high insulin content and secretion in response to increasing glucose levels. 4-Methylcatechol (4-MC) is a metabolite of quercetin, which is known as a potential drug for inhibition of tumorigenesis. The aim of this study was to determine the applying doses of 4-methylcatechol (4-MC) for triggening cell death and decreasing the cell function of rat insulinoma INS-1 beta cells. The rate of apoptosis and the amount of insulin i… Show more

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Cited by 3 publications
(2 citation statements)
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“…Clostridium_ Symbiosum decreased significantly after treatment, and its negatively related FAHFA (Fatty acid esters of hydroxy fatty acids) has anti-inflammatory effect and can inhibit the production of LPS induced pro-inflammatory cytokines in macrophages and dendritic cells ( Yore et al., 2014 ). Erysipelatoclostridium_ Ramosum that reduced after treatment was negatively correlated with LAP (plasma lysophosphatidic acid) and 4_ Methylcatechol, both of which could promote tumor cell apoptosis ( Zheng et al., 2004 ; Karatug Kacar et al., 2018 ). In patient case 2, Streptoccus_ Parasanguinis and dialist_ Pneumosintes decreased after treatment and were negatively correlated with 13(S)-HOTrE which can produce anti-inflammatory effect by inactivating NLRP3 inflammatory body complex ( Kumar et al., 2016 ).…”
Section: Discussionmentioning
confidence: 99%
“…Clostridium_ Symbiosum decreased significantly after treatment, and its negatively related FAHFA (Fatty acid esters of hydroxy fatty acids) has anti-inflammatory effect and can inhibit the production of LPS induced pro-inflammatory cytokines in macrophages and dendritic cells ( Yore et al., 2014 ). Erysipelatoclostridium_ Ramosum that reduced after treatment was negatively correlated with LAP (plasma lysophosphatidic acid) and 4_ Methylcatechol, both of which could promote tumor cell apoptosis ( Zheng et al., 2004 ; Karatug Kacar et al., 2018 ). In patient case 2, Streptoccus_ Parasanguinis and dialist_ Pneumosintes decreased after treatment and were negatively correlated with 13(S)-HOTrE which can produce anti-inflammatory effect by inactivating NLRP3 inflammatory body complex ( Kumar et al., 2016 ).…”
Section: Discussionmentioning
confidence: 99%
“…This evidenced that the cells have not been biologically changed. The experimental results are shown in our previous study . The INS‐1 cells between passages 2–9 were used for experiments in our previous study.…”
Section: Methodsmentioning
confidence: 99%