1997
DOI: 10.1016/s0021-9150(97)89838-3
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4.P.310 Particle size determines both the receptor specificity of apoE-containing emulsions in vivo and the α-helical content of apoE

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Cited by 8 publications
(23 citation statements)
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“…In WT mice, the majority of the injected dose associated with the liver (50% of the dose at 10 min after injection) (Fig. 3B), which is in agreement with our previous observations (46). In contrast, the hepatic association of emulsion particles was strongly reduced in SR-BI KO mice (10% of the dose at 10 min after injection).…”
Section: Effect Of Sr-bi Deficiency On the Kinetics Of Tg-rich Chylomsupporting
confidence: 92%
See 1 more Smart Citation
“…In WT mice, the majority of the injected dose associated with the liver (50% of the dose at 10 min after injection) (Fig. 3B), which is in agreement with our previous observations (46). In contrast, the hepatic association of emulsion particles was strongly reduced in SR-BI KO mice (10% of the dose at 10 min after injection).…”
Section: Effect Of Sr-bi Deficiency On the Kinetics Of Tg-rich Chylomsupporting
confidence: 92%
“…Earlier studies from our group have indicated that small emulsion particles (i.e. 50 nm) are solely recognized by the LDLr in vivo (46), whereas the hepatic recognition of large emulsions (i.e. 150 nm) is exerted by a remnant receptor system of unidentified nature (22,23,51).…”
Section: Effect Of Sr-bi Deficiency On Chylomicron Metabolism Inmentioning
confidence: 91%
“…The total amount of radioactivity in the plasma was calculated based on the estimated total plasma volume (4.5% of body weight, Refs. 17,18). To determine liver uptake, the livers were weighed, and tissue samples were treated with soluene-350 (PerkinElmer Life Sciences).…”
Section: Methodsmentioning
confidence: 99%
“…Hereto, 100 mg of total lipid at a weight ratio of triolein:egg yolk phosphatidylcholine: lysophosphatidylcholine:cholesterYl oleate:cholesterol (70:22.7:2.3:3.0: 2.0) supplemented with 50 -200 Ci of [ 3 H]triolein was sonicated using a Soniprep 150 (MSE Scientific Instruments) at an output of 10 m. An emulsion fraction containing 80-nm sized emulsion particles was obtained by consecutive density gradient ultracentrifugation steps exactly as described previously (16). The TG content of emulsions was determined as described above.…”
Section: Materials-glycerolmentioning
confidence: 99%
“…At 5 days after adenoviral injection, serum clearance and tissue distribution of VLDL-like emulsion particles was studied as detailed elsewhere (16). The fed mice were anesthetized as described above, and their abdomens were opened.…”
Section: Materials-glycerolmentioning
confidence: 99%